Yaohua He
Shanghai Jiao Tong University
Biomedical engineeringNuclear chemistryPathologyRegeneration (biology)ChemistryMetallurgyMaterials scienceMesenchymal stem cellIn vivoMagnesium alloyBiocompatibilityDrug deliveryAlloyWound healingAngiogenesisStem cellBone regenerationTube formationChemical engineeringMagnesiumMedicineScaffoldCell biology
44Publications
20H-index
1,809Citations
Publications 46
Newest
#1Haoran Liao (SJTU: Shanghai Jiao Tong University)
#2Han-Ping Yu (CAS: Chinese Academy of Sciences)H-Index: 5
Last. Yaohua He (SJTU: Shanghai Jiao Tong University)H-Index: 20
view all 8 authors...
Background null Rotator cuff tear (RCT) is a common problem of the musculoskeletal system. With the advantage of promoting bone formation, calcium phosphate materials have been widely used to augment tendon-bone healing. However, only enhancing bone regeneration may be not enough for improving tendon-bone healing. Angiogenesis is another fundamental factor required for tendon-bone healing. Therefore, it's necessary to develop a convenient and reliable method to promote osteogenesis and angiogene...
Source
#1Weilin YuH-Index: 1
#2Wei SongH-Index: 4
Last. Chongyang WangH-Index: 5
view all 5 authors...
Objectives:Chronic rotator cuff tendinopathy is one of the most prevalent causes of shoulder pain. Growing evidence suggests that macrophages play a significant role in the pathogenesis of tendinop...
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#1Chongyang Wang (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Yao Zhang (SJTU: Shanghai Jiao Tong University)
Last. Yaohua HeH-Index: 20
view all 5 authors...
Background:Chronic rotator cuff (RC) tendinopathy is one of the most prevalent causes of shoulder pain. Growing evidence suggests that macrophages play a significant role in the proinflammatory res...
Source
#1Huakun Zhao (SJTU: Shanghai Jiao Tong University)H-Index: 9
#2Lingzhi Kong (SJTU: Shanghai Jiao Tong University)H-Index: 3
Last. Yaohua He (SJTU: Shanghai Jiao Tong University)H-Index: 20
view all 7 authors...
BACKGROUND Frozen shoulders (FS) is a major clinical concern, where chronic synovial inflammation, abnormal angiogenesis, and fibrosis represent the critical pathologies in the glenohumeral capsule. However, no pharmacotherapy has been introduced to treat this pathology. Tetrandrine (TET) has been proposed as a treatment for many diseases due to its strong anti-inflammatory, anti-angiogenic, and anti-fibrotic effects. PURPOSE To study the anti-inflammatory, anti-angiogenic, and anti-fibrotic eff...
Source
#1Zhenyu Ding (SJTU: Shanghai Jiao Tong University)H-Index: 7
#2Zhenlong Bai (SJTU: Shanghai Jiao Tong University)
Last. Yaohua He (SJTU: Shanghai Jiao Tong University)H-Index: 20
view all 5 authors...
Pigmented villonodular synovitis (PVNS) is a rare hyperplasia disease of the synovium with a predilection for the knee in either a localized (LPVNS) or a diffuse form (DPVNS). But the exact cause is not clear. The aim of this study was to explore the relationship between the expression of cellular inhibitor of apoptosis 2 (cIAP2) and proliferation, apoptosis, invasive growth and postoperative recurrence in PVNS. Clinical significance of cIAP2 expression in synovium from 63 patients' knee joints ...
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#1Yanlun Zhu (CUHK: The Chinese University of Hong Kong)H-Index: 5
#2Zhijie Ma (SJTU: Shanghai Jiao Tong University)H-Index: 5
Last. Haiyan Li (SJTU: Shanghai Jiao Tong University)H-Index: 59
view all 6 authors...
Abstract Inflammatory response is a critical stage in typical wound healing. Although studies have reported that some bioactive materials can modulate the polarization of macrophages to benefit tissue regeneration, the roles of the inflammatory responses, especially the crucial roles of macrophages, in tissue regeneration stimulated by biomaterials remains unclear. Bioactive glass (BG) and hydrogel containing BG have been reported to be able to promote both hard and soft tissue regeneration. How...
Source
#1Zhijie Ma (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Wei Song (SJTU: Shanghai Jiao Tong University)H-Index: 4
Last. Haiyan Li (SJTU: Shanghai Jiao Tong University)H-Index: 59
view all 4 authors...
Wound healing is a dynamic and complex process that contains several sequential phases. However, most of the current drug delivery systems were designed to treat only one certain phase of wound rep...
Source
#1Chongyang Wang (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Qingxiang Hu (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Yaohua He (SJTU: Shanghai Jiao Tong University)H-Index: 20
view all 5 authors...
BACKGROUND: Fatty infiltration and poor tendon-bone healing in chronic rotator cuff tears (RCTs) are associated with unsatisfactory prognosis. Adipose stem cell-derived exosomes (ASC-Exos), having multiple biological effects, can prevent muscle degeneration in acute RCTs. However, the effects of ASC-Exos on fatty infiltration and tendon-bone healing in chronic RCTs remain unknown. PURPOSE: To study the effects of ASC-Exos on fatty infiltration and tendon-bone healing in a chronic RCT rabbit mode...
Source
#1Weihan Yu (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Yanlun Zhu (CUHK: The Chinese University of Hong Kong)H-Index: 5
Last. Yaohua He (SJTU: Shanghai Jiao Tong University)H-Index: 20
view all 4 authors...
Articular cartilage plays an important role in human body. How to repair articular cartilage defects when they appeared due to various factors has always been a major clinical challenge. Recently, studies have shown that slowing the degradation of cartilage extracellular matrix (ECM) and modulating the inflammatory response of the host thereby promoting cartilage tissue regeneration are important in the cartilage repair process. In this study, a drug-loaded injectable hydrogel was constructed fo...
Source
#1Wei Song (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Zhijie Ma (SJTU: Shanghai Jiao Tong University)H-Index: 5
Last. Yaohua He (SJTU: Shanghai Jiao Tong University)H-Index: 20
view all 5 authors...
Reconstructing the native structure of the tendon-to-bone insertion site (enthesis) in rotator cuff repair has always been a great challenge for orthopedic surgeons. Difficulty arises mainly due to the limited enthesis regenerative capability and severe inflammatory cell infiltration, which result in fibrovascular scar formation instead of native cartilage-like enthesis. Therefore, tissue engineering scaffolds with pro-chondrogenic and immunomodulatory capabilities may offer a new strategy for n...
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