Paul A. Decker
Mayo Clinic
CancerInternal medicineSurgeryPathologyOncologySingle-nucleotide polymorphismRetrospective cohort studyPhysical therapyPsychological interventionTemozolomideSmoking cessationGliomaIntervention (counseling)PopulationCancer researchClinical trialGeneticsClinical psychologyMedicineBiology
Publications 312
#1Israel J Mendez (UPR: University of Puerto Rico)
#2Sheila M. Manemann (Mayo Clinic)H-Index: 19
Last. Michael Y. Tsai (UMN: University of Minnesota)H-Index: 76
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BACKGROUND The cellular adhesion pathway has been suggested as playing an important role in the pathogenesis of atrial fibrillation (AF). However, prior studies that have investigated the role of adhesion pathway proteins in risk of AF have been limited in the number of proteins that were studied and in the ethnic and racial diversity of the study population. Therefore we aimed to study the associations of fifteen adhesion pathway proteins with incident AF in a large, diverse population. METHODS...
#1Pamela S. Sinicrope (Mayo Clinic)H-Index: 12
#2Laura A. Maciejko (Mayo Clinic)
Last. Christi A. Patten (Mayo Clinic)H-Index: 51
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Objective To identify motivators and barriers to wearing a mask to prevent COVID-19. Participants and methods An anonymous, online survey of adults from Southeastern Minnesota conducted August 2020. We assessed willingness to wear a mask and its associations with socio-demographics, COVID-19-related factors and prevention behaviors using multivariable ordinal logistic regression. Results Of 7,786 respondents (78% women, 51% rural), 9% reported 'not at all willing', 27% 'willing', and 64% 'very w...
#1Federica De Giacomi (Mayo Clinic)H-Index: 9
#2Darin B. White (Mayo Clinic)H-Index: 7
Last. Teng Moua (Mayo Clinic)H-Index: 17
view all 8 authors...
Abstract null null Background null Clinical differentiation of fibrotic hypersensitivity pneumonitis (f-HP) remains challenging given variable and overlapping presentations with other fibrotic interstitial lung disease (f-ILD). null null null Objective null We derived a multivariable model for predicting histopathologic f-HP to better inform multidisciplinary team discussion (MDD) diagnosis, particularly when biopsy may be unsafe or cannot be achieved. null null null Methods null Patients with h...
#1Daniel Gonzalez-Izundegui (Mayo Clinic)H-Index: 1
#2Alejandro Campos (Mayo Clinic)
Last. Barham K. Abu Dayyeh (Mayo Clinic)H-Index: 31
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Objective null Satiety, defined as the duration of the sensation of fullness, is usually measured by validated visual analog scales (VAS) for appetite. Gastric function plays a key role in food intake regulation. However, the association between gastric emptying (GE) and VAS appetite is unknown. null Methods null In this cross-sectional study, 134 participants (mean [SEM] age = 39 [0.8] years, mean [SEM] BMI = 38 [0.5] kg/m2 , 67% females) completed simultaneous measurements of GE and VAS appeti...
1 CitationsSource
#1Danielle M. Burgenske (Mayo Clinic)H-Index: 2
#2Surabhi Talele (UMN: University of Minnesota)H-Index: 1
Last. Gautham Gampa (UMN: University of Minnesota)H-Index: 6
view all 22 authors...
BACKGROUND Glioblastoma (GBM) is an incurable disease with few approved therapeutic interventions. Radiation therapy (RT) and temozolomide (TMZ) remain the standards of care. The efficacy and optimal deployment schedule of the orally bioavailable small-molecule tumor checkpoint controller lisavanbulin alone, and in combination with, standards of care were assessed using a panel of IDH-wildtype GBM patient-derived xenografts. METHODS Mice bearing intracranial tumors received lisavanbulin +/- RT +...
#1Desmond A. BrownH-Index: 8
#2Anshit GoyalH-Index: 13
Last. Michael Opoku-DarkoH-Index: 4
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OBJECTIVE The objective of this study was to determine the frequency with which brain biopsy for presumed CNS relapse of systemic hematological malignancies yields new, actionable diagnostic information. Hematological malignancies represent a disparate group of genetic and histopathological disorders. Proclivity for brain involvement is dependent on the unique entity and may occur synchronously or metasynchronously with the systemic lesion. Diffuse large B-cell lymphomas (DLBCLs) have a high pro...
#1Jeanette E. Eckel-Passow (Mayo Clinic)H-Index: 45
#2Gaspar J. Kitange (Mayo Clinic)H-Index: 27
Last. Jann N. Sarkaria (Mayo Clinic)H-Index: 67
view all 7 authors...
Background null Appropriately designed preclinical patient-derived xenograft (PDX) experiments are important to accurately inform human clinical trials. There is little experimental design guidance regarding choosing the number of PDX lines to study, and the number of mice within each PDX line. null Methods null Retrospective data from IDH-wildtype glioblastoma preclinical experiments evaluating a uniform regimen of fractionated radiation (RT), temozolomide (TMZ) chemotherapy, and concurrent RT/...
Purpose null The depth and breadth of clinical data within electronic health record (EHR) systems paired with innovative machine learning methods can be leveraged to identify novel risk factors for complex diseases. However, analysing the EHR is challenging due to complexity and quality of the data. Therefore, we developed large electronic population-based cohorts with comprehensive harmonised and processed EHR data. null Participants null All individuals 30 years of age or older who resided in ...
#1Bianca Maria Marin (Mayo Clinic)H-Index: 1
#2Kendra A Porath (Mayo Clinic)
Last. Jann N. Sarkaria (Mayo Clinic)H-Index: 67
view all 30 authors...
BACKGROUND Antibody drug conjugates (ADCs) targeting the epidermal growth factor receptor (EGFR), such as depatuxizumab mafodotin (Depatux-M), is a promising therapeutic strategy for glioblastoma (GBM) but recent clinical trials did not demonstrate a survival benefit. Understanding the mechanisms of failure for this promising strategy is critically important. METHODS PDX models were employed to study efficacy of systemic vs intracranial delivery of Depatux-M. Immunofluorescence and MALDI-MSI wer...
#1Sheila M. Manemann (Mayo Clinic)H-Index: 19
#2Suzette J. Bielinski (Mayo Clinic)H-Index: 32
Last. Nicholas B. Larson (Mayo Clinic)H-Index: 17
view all 10 authors...