Gaurav Choudhary
Brown University
Internal medicineEndocrinologyPulmonary wedge pressureCardiologyRetrospective cohort studyChemistryApoptosisHazard ratioVeterans AffairsLungHeart failurePulmonary hypertensionPulmonary arteryPopulationDiabetes mellitusVascular resistanceMedicineCohortBlood pressureCell biology
Publications 149
#1Reema Qureshi (Providence VA Medical Center)H-Index: 1
#2Yevgeny Vayntrub (Brown University)
Last. Matthew D. Jankowich (Providence VA Medical Center)H-Index: 14
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Case Presentation null A 64-year-old man with a past medical history of alcoholic cirrhosis with resultant hepatorenal syndrome requiring kidney and liver transplantation 10 years previously sought treatment at the ED with progressive lower-extremity edema and dyspnea. After noting worsening shortness of breath and cough as an outpatient, he had been referred to a pulmonary clinic and was undergoing a workup for interstitial lung disease (ILD). He had been started on prednisone 40 mg/d after a l...
#1Phillip H. Lam (Veterans Health Administration)H-Index: 10
#2Kalliopi Keramida (GW: George Washington University)
Last. Gaurav Choudhary (Brown University)H-Index: 25
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Abstract null null Background null A low right ventricular ejection fraction (RVEF) is a marker of poor outcomes in patients with heart failure with reduced ejection fraction (HFrEF). Beta-blockers improve outcomes in HFrEF, but whether this effect is modified by RVEF is unknown. null null null Methods and Results null Of the 2798 patients in Beta-Blocker Evaluation of Survival Trial (BEST), 2008 had data on baseline RVEF (mean 35%, median 34%). Patients were categorized into an RVEF of less tha...
#1Xiaofei Li (Rhode Island Hospital)
#2Julie Braza (Providence VA Medical Center)H-Index: 1
Last. Peng Zhang (Providence VA Medical Center)H-Index: 14
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Left ventricular remodeling due to pressure overload is associated with poor prognosis. Sacubitril/valsartan is the first-in-class Angiotensin Receptor Neprilysin Inhibitor and has been demonstrated to have superior beneficial effects in the settings of heart failure. The aim of this study was to determine whether sacubitril/valsartan has cardioprotective effect in the early intervention of pressure overloaded hearts and whether it is superior to valsartan alone. We induced persistent left ventr...
#1Matthew D. Jankowich (Veterans Health Administration)H-Index: 14
#2Bradley A. Maron (Veterans Health Administration)H-Index: 32
Last. Gaurav Choudhary (Veterans Health Administration)H-Index: 25
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Pulmonary hypertension is associated with increased morbidity and mortality, and growing evidence suggests that even mild elevations in pulmonary artery pressure estimated with echocardiography are linked to increased mortality. In healthy individuals who undergo right heart catheterisation, the average pulmonary artery systolic pressure ranges from 17 mm Hg to 25 mm Hg; on echocardiography, estimated pulmonary artery systolic pressure of more than 30 mm Hg is outside the normal range for most h...
#1Alexander Vang (Providence VA Medical Center)H-Index: 8
#2Denielli da Silva Gonçalves Bos (Providence VA Medical Center)
Last. Gaurav Choudhary (Providence VA Medical Center)H-Index: 25
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Right ventricular (RV) fibrosis is a key feature of maladaptive RV hypertrophy and dysfunction and is associated with poor outcomes in pulmonary hypertension (PH). However, mechanisms and therapeutic strategies to mitigate RV fibrosis remain unrealized. Previously, we identified that cardiac fibroblast α7 nicotinic acetylcholine receptor (α7 nAChR) drives smoking induced RV fibrosis. Here we sought to define the role of α7 nAChR in RV dysfunction and fibrosis in the settings of RV pressure overl...
#1Sebhat Erqou (Providence VA Medical Center)
#2Lan Jiang (Providence VA Medical Center)H-Index: 12
Last. Wen-Chih WuH-Index: 27
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Background Although HIV is associated with increased risk of heart failure (HF), it is not known if people living with HIV develop HF at a younger age compared with individuals without HIV. Crude c...
#1Hojune E. Chung (Brown University)H-Index: 1
#2Jessica Chen (Brown University)
Last. Alan R. Morrison (Brown University)H-Index: 11
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