Zhangang Xiao
Chinese Ministry of Education
GeneCancerInternal medicineDownregulation and upregulationOncologymicroRNAChemistryApoptosisIn vivoTumor microenvironmentImmunotherapyHepatocellular carcinomaCancer immunotherapyCancer researchSignal transductionMedicineBiologyImmune systemCell biologyCancer cell
71Publications
21H-index
998Citations
Publications 63
Newest
#2Zhuo ZhangH-Index: 3
Last. Yu ChenH-Index: 1
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#1Hanyu Zhang (North Sichuan Medical College)H-Index: 6
Last. Zhangang XiaoH-Index: 21
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Gastric cancer (GC) development is a complex process displaying polytropic cell and molecular landscape within gastric tumor microenvironment (TME). Stromal cells in TME, including fibroblasts, endothelial cells, mesenchymal stem cells, and various immune cells, support tumor growth, metastasis, and recurrence, functioning as the soil for gastric tumorigenesis. Importantly, exosomes secreted by either stromal cells or tumor cells during tumor-stroma crosstalk performed as crucial transporter of ...
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#2Yifan LiH-Index: 1
Last. Zhigui Wu
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Abstract null null Objectives: Vitamin D deficiency was found to be associated with increased risk for gastric cancer (GC). We previously found that vitamin D inhibited GC cell growth in vitro. However, the in vivo antitumor effect of vitamin D in GC as well as the underlying mechanisms are not well understood. The aim of this study was to investigate the anticancer effect of vitamin D on GC both in vitro and in vivo. null Methods: Human GC cells MKN45, MKN28, and KATO III were used. The express...
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#2Hongxun Tao (UM: University of Macau)H-Index: 6
Last. Xu WuH-Index: 15
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Rhodiola species are edible medicinal plants, which have been traditionally used in both Asia and Europe as an adaptogen, a tonic, an anti-depressant and anti-inflammatory supplement. However, whether it presents a therapeutic effect on colitis or not remains unknown. The aim of this study is to investigate the protective effect of a Rhodiola crenulata extract (RCE) on mice with DSS-induced colitis. RCE significantly alleviated the pathological abnormalities in colitic mice, including the corres...
2 CitationsSource
#1Shixin XiangH-Index: 3
#2Jing LiH-Index: 7
Last. Zhangang XiaoH-Index: 21
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Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world. The efficacy of immunotherapy usually depends on the interaction of immunomodulation in the tumor microenvironment (TME). This study aimed to explore the potential stromal-immune score-based prognostic genes related to immunotherapy in HCC through bioinformatics analysis. Methods: ESTIMATE algorithm was applied to calculate the immune/stromal/Estimate scores and tumor purity of HCC using the Cance...
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#1Hanyu ZhangH-Index: 6
#2Mingxing LiH-Index: 19
Last. Zhangang XiaoH-Index: 21
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Background:Cluster of differentiation molecules are markers of immune cells that have been identified as a potential immunotherapeutic target for cancer treatment. MicroRNAs are small non-coding RN...
1 CitationsSource
#1Qijie ZhaoH-Index: 7
Last. Zhangang XiaoH-Index: 21
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This review provides insight into the role of engineered T-cell receptors (TCRs) in immunotherapy. Novel approaches have been developed to boost anticancer immune system, including targeting new antigens, manufacturing new engineered or modified TCRs, and creating a safety switch for endo-suicide genes. In order to re-activate T cells against tumors, immune-mobilizing monoclonal TCRs against cancer (ImmTAC) have been developed as a novel class of manufactured molecules which are bispecific and r...
2 CitationsSource
#1Huimin HuangH-Index: 2
#2Mingxing LiH-Index: 19
Last. Xu WuH-Index: 15
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Background: Longan is the fruit of Dimocarpus longan Lour. and the longan arillus has long been used in traditional Chinese medicine possessing various health benefits. However, the excessive intake of longan is found in daily life to cause "shanghuo" syndrome. "Shanghuo" has been linked to increased disease susceptibility. The present study thus aimed to investigate the toxicological outcomes after excessive longan treatment. Methods: Longan extract at a normal dosage of 4 g/kg and two excess d...
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Fibrinogen-associated protein (FREP) family is a family of proteins with a fibrin domain at the carboxyl terminus. Recent investigations illustrated that two members of FREP family, fibrinogen-like protein-1 (FGL1) and fibrinogen-like protein-2 (FGL2), play crucial roles in cancer by regulating the proliferation, invasion, and migration of tumor cells, or regulating the functions of immune cells in tumor microenvironment. Meanwhile, they are potential targets for medical intervention of tumor de...
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Objectives: Several reports suggesting that the intestinal microbiome plays a key role in the development of inflammatory bowel disease (IBD) or colorectal cancer (CRC), but the changes of intestinal bacteria in healthy people, patients with IBD and CRC are not fully explained. The study aimed to investigate changes of intestinal bacteria in healthy subjects, patients with IBD, and patients with CRC. Materials: We collected data from the European Nucleotide Archive on healthy people and patients...
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