William T. Harris
University of Alabama at Birmingham
AirwayTransforming growth factorInternal medicinePathologySocioeconomic statusIntensive care medicineChemistryPediatricsImmunologyRespiratory diseaseIvacaftorCystic fibrosisLungBronchoalveolar lavageCystic fibrosis transmembrane conductance regulatorPopulationTobacco smoke exposureCancer researchMedicinePulmonary function testingGastroenterologyCell biology
44Publications
16H-index
960Citations
Publications 45
Newest
#1R.E. Wineski (UAB: University of Alabama at Birmingham)
#2Emma C. Panico (UAB: University of Alabama at Birmingham)
Last. R. Kassel (UAB: University of Alabama at Birmingham)
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Abstract null null Introduction null The best strategy to manage an interarytenoid defect [Type 1 laryngeal cleft (LC-1) or deep interarytenoid groove (DIG)] in pediatric aerodigestive patients with dysphagia remains uncertain. This study compared benefit of interarytenoid augmentation (IAA) to suture repair or clinical observation alone in pediatric patients. null null null Methods null A 3-year retrospective, single-center analysis of children with dysphagia undergoing endoscopic airway evalua...
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#1Gabriela R. Oates (UAB: University of Alabama at Birmingham)H-Index: 11
#2Elizabeth A. Baker (UAB: University of Alabama at Birmingham)H-Index: 48
Last. William T. Harris (UAB: University of Alabama at Birmingham)H-Index: 16
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Abstract null null Background null Tobacco smoke exposure is a major risk factor for the health of children and adolescents with CF. In this study, we assess whether cessation of smoke exposure is associated with improved outcomes in this population. null null null Methods null We used annualized and encounter-based data from the U.S. CF Foundation Patient Registry (2006-2018) on all individuals born 1998-2010. The analytical sample included those who ever reported second-hand smoke exposure (da...
1 CitationsSource
#1Elizabeth A. Baker (UAB: University of Alabama at Birmingham)H-Index: 48
#2William T. Harris (UAB: University of Alabama at Birmingham)H-Index: 16
Last. C.M. Fowler (UAB: University of Alabama at Birmingham)
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Abstract Objectives Tobacco smoke exposure reduces CFTR functional expression in vitro and contributes to acquired CFTR dysfunction. We investigated whether it also inhibits the clinical benefit of CFTR modulators, focusing on tezacaftor/ivacaftor, approved in February 2018 for individuals with CF age ≥12 years. Methods A retrospective longitudinal analysis of encounter-based data from the CF Foundation Patient Registry (2016–2018) compared the slope of change in lung function (GLI FEV1% predict...
3 CitationsSource
#1Gabriela R. Oates (UAB: University of Alabama at Birmingham)H-Index: 11
#2Elizabeth H. Baker (UAB: University of Alabama at Birmingham)H-Index: 12
Last. William T. Harris (UAB: University of Alabama at Birmingham)H-Index: 16
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Abstract Background Pulmonary decline in CF is heterogeneous, with socio-environmental factors contributing to this variability. Few studies have attempted to disentangle the effects of tobacco smoke exposure and socioeconomic factors on lung function deterioration in pediatric CF. The current study evaluates their contributions longitudinally across the entire U.S. CF care network population. Methods Data from the CF Foundation Patient Registry were obtained on all individuals who at the end of...
11 CitationsSource
#1Gabriela R. OatesH-Index: 11
#2Elizabeth A. BakerH-Index: 48
Last. William T. HarrisH-Index: 16
view all 5 authors...
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#1Gabriela R. Oates (UAB: University of Alabama at Birmingham)H-Index: 11
#2William T. Harris (UAB: University of Alabama at Birmingham)H-Index: 16
Last. Susan C. Walley (UAB: University of Alabama at Birmingham)H-Index: 9
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OBJECTIVE Tobacco smoke exposure has negative impacts on the lung health of children with cystic fibrosis (CF), yet evidence-based strategies for smoking cessation have not been tested with or tailored to CF caregivers. This qualitative study identified barriers and facilitators of smoking cessation in this population and outlined potential interventional approaches. METHODS We conducted semi-structured interviews with CF familial caregivers who were current or former smokers, and with members o...
3 CitationsSource
#1Andrew P. Klinger (UAB: University of Alabama at Birmingham)H-Index: 2
#2Colm P. Travers (UAB: University of Alabama at Birmingham)H-Index: 9
Last. Namasivayam Ambalavanan (UAB: University of Alabama at Birmingham)H-Index: 67
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To determine normative data by forced oscillation technique (FOT) in non-sedated normal term neonates and test the hypothesis that infants with transient tachypnea of the newborn (TTN) have higher resistance (R) and lower reactance (X) on day 1. Healthy term infants (n = 138) and infants with TTN (n = 17) were evaluated on postnatal days 1 through 3 (NCT03346343). FOT was measured with a mask using a TremoFlo C-100 Airwave System™. R, X, and area under the reactance curve (AX) were measured at p...
4 CitationsSource
#1Margaret Rosenfeld (Seattle Children's)H-Index: 64
#2Steve Cunningham (Edin.: University of Edinburgh)H-Index: 26
Last. Jane C. Davies (NIH: National Institutes of Health)H-Index: 61
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Abstract Background KIWI ( NCT01705145 ) was a 24-week, single-arm, pharmacokinetics, safety, and efficacy study of ivacaftor in children aged 2 to 5 years with cystic fibrosis (CF) and a CFTR gating mutation. Here, we report the results of KLIMB ( NCT01946412 ), an 84-week, open-label extension of KIWI. Methods Children received age- and weight-based ivacaftor dosages for 84 weeks. The primary outcome was safety. Other outcomes included sweat chloride, growth parameters, and measures of pancrea...
33 CitationsSource
Background:In US cystic fibrosis (CF) patients, methicillin-resistant Staphylococcus aureus (MRSA) rates have tripled in the past 2 decades. Known clinical risk factors include exposure to a healthcare setting, Pseudomonas aeruginosa and CF-related diabetes. Area-level socio-environmental exposures
6 CitationsSource
#1Alisha Holtzhausen (UNC: University of North Carolina at Chapel Hill)H-Index: 7
#2William T. Harris (UNC: University of North Carolina at Chapel Hill)H-Index: 16
Last. H. Shelton Earp (UNC: University of North Carolina at Chapel Hill)H-Index: 63
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Myeloid cell receptor tyrosine kinases TYRO3, AXL, and MERTK and their ligands, GAS6 and PROTEIN S, physiologically suppress innate immune responses, including in the tumor microenvironment. Here, we showed that myeloid-derived suppressor cells (MDSC) dramatically upregulated TYRO3, AXL, and MERTK and their ligands [monocytic MDSCs (M-MDSC)>20-fold, polymorphonuclear MDSCs (PMN-MDSC)>15-fold] in tumor-bearing mice. MDSCs from tumor-bearing Mertk−/−, Axl−/−, and Tyro3−/− mice exhibited diminished...
23 CitationsSource