V. I. Chernov
Tomsk Polytechnic University
CancerInternal medicineRadiologyPathologyCerebral perfusion pressureCardiologyChemistryMedical physicsChemotherapyAxillary lymph nodesGamma probeEmission computed tomographyCervical cancerLymphSentinel lymph nodeSingle-photon emission computed tomographyLarynxTechnetium-99Lymph nodeAluminum oxideNuclear medicineIn patientCancer researchBreast cancerMedicineEjection fraction
49Publications
5H-index
61Citations
Publications 48
Newest
#2V. I. ChernovH-Index: 5
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Last. V. I. ChernovH-Index: 5
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1 CitationsSource
Last. Svetlana ChizhevskayaH-Index: 1
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#1A. A. MedvedevaH-Index: 1
#2V. I. ChernovH-Index: 5
Last. A. V. GoldbergH-Index: 1
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The diagnostic capabilities of nuclear medicine imaging in the detection and assessment of the spread of laryngeal/hypopharyngeal cancer were studied. A total of 40 patients with histologically verified laryngeal and hypopharyngeal cancer and 20 patients with benign laryngeal lesions were included into the study. Submucosal injections of 99mTc-MIBI and 99mTc-Alotech were made around the tumor. Single photon emission computed tomography (SPECT) was performed 20 minutes after the injection of 99mT...
2 CitationsSource
#1V. I. ChernovH-Index: 5
#2R. ZeltchanH-Index: 3
Last. O. D. BraginaH-Index: 1
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Early cancer diagnosis remains one of the most actual problems of medicine, since it allows using the most effective methods of cancer treating. Unlike most diagnostic methods used in oncology, the methods of nuclear medicine allow assessing not so much the anatomic changes in the organ as the disturbance of metabolic processes in tumors and surrounding tissues. The authors describe the main radiopharmaceuticals used for diagnose and radiotherapy of malignant tumors.
1 CitationsSource
#1M. S. Lar’kinaH-Index: 3
Last. Sergey M. DeyevH-Index: 29
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The selection of precursors (for example chelating agents) and development of a technique of chemical modification of the target molecules retaining its ability to bind to specific receptors are very important in the synthesis of radiopharmaceuticals. As some important precursors for target radiopharmaceuticals omega-iodo-aliphatic carboxylic acids and their esters can be used. We have developed an environmentally safe process for producing omega-iodo-aliphatic carboxylic acids and their esters ...
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#1O.D. BraginaH-Index: 4
#2M. S. Lar’kinaH-Index: 3
Last. M. BuldakovH-Index: 1
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It is still necessary to search for new informative diagnostic methods to detect malignant tumors with overexpression of Her-2/neu, which are characterized by the aggressive course of the disease, rapid rate of tumor growth and low rates of relapse-free and overall survival. In recent years, the radioisotope techniques for detection of specific tumor targets have been developing actively. Purpose: to develop a chemically stable radiochemical compound for the targeted imaging of cells overexpress...
1 CitationsSource
#1R. ZeltchanH-Index: 3
#2A. A. MedvedevaH-Index: 1
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The preclinical studies of 99mTc-1-Thio-D-glucose, a new tumor-seeking agent based on technetium-99m-labeled glucose derivative, were conducted, and the feasibility of using this radiopharmaceutical for tumor visualization was studied. The preclinical studies were carried out strictly in accordance with the local legislation and were regulated by the generally accepted research standards. 99mTc-1-Thio-D-glucose was found to have optimal pharmacokinetic and physico-chemical properties for diagnos...
2 CitationsSource
Last. O.D. BraginaH-Index: 4
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The purpose of the study: to assess the possibility of using nuclear medicine techniques at the stages of diagnosis and treatment of breast cancer. Materials and Methods: The study included 290 patients with breast cancer and 70 patients with benign breast tumors. The study was used as a radiopharmaceutical 99mTc-MIBI, 199Tl for imaging tumors and colloid 99mTc-Aloteh for visualization sentinel lymph nodes (SLN), colloid was injected peritumoral in four points to 80 MBq one day prior to the plan...
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#1I. G. SinilkinH-Index: 4
#2V. I. ChernovH-Index: 5
Last. O.D. BraginaH-Index: 4
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The clinical significance of determining sentinel lymph nodes (SLN) in patients with invasive cervical cancer was studied. From 2013 to 2014, 30 cervical cancer patients (T1a1NxM0–T1b1NxM0) were treated at the Gynecological Oncology Department of the Cancer Research Institute. The day before surgery, four submucosal injections of 99mTc Al2O3 at a total dose of 80 MBq were made in each quadrant around the cervical tumor. Patients were submitted to preoperative lymphoscintigraphy and intraoperativ...
1 CitationsSource