Fiona McDonald
The Royal Marsden NHS Foundation Trust
Internal medicineRadiologySurgeryMagnetic resonance imagingOncologyStage (cooking)Medical physicsLung cancerChemotherapyLungChemoradiotherapyDiseasenon-small cell lung cancer (NSCLC)Bladder cancerNuclear medicineNon small cellLocally advancedMr linacRadiation therapyMedicine
Publications 126
#1A Punjabi (University of Manchester)
#2E. Barrett (University of Manchester)
Last. Matthew Evison (University of Manchester)H-Index: 13
view all 24 authors...
AIMS The neutrophil-lymphocyte ratio (NLR) and the absolute lymphocyte count (ALC) have been proposed as prognostic markers in non-small cell lung cancer (NSCLC). The objective of this study was to examine the association of NLR/ALC before and after curative-intent radiotherapy for NSCLC on disease recurrence and overall survival. MATERIALS AND METHODS A retrospective study of consecutive patients who underwent curative-intent radiotherapy for NSCLC across nine sites in the UK from 1 October 201...
#1Joshua N Freedman (The Royal Marsden NHS Foundation Trust)H-Index: 3
#2Oliver J. Gurney-Champion (The Royal Marsden NHS Foundation Trust)H-Index: 12
Last. Andreas Wetscherek (The Royal Marsden NHS Foundation Trust)H-Index: 12
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BACKGROUND AND PURPOSE 4D and midposition MRI could inform plan adaptation in lung and abdominal MR-guided radiotherapy. We present deep learning-based solutions to overcome long 4D-MRI reconstruction times while maintaining high image quality and short scan times. METHODS Two 3D U-net deep convolutional neural networks were trained to accelerate the 4D joint MoCo-HDTV reconstruction. For the first network, gridded and joint MoCo-HDTV-reconstructed 4D-MRI were used as input and target data, resp...
#1Fiona McDonaldH-Index: 20
#2F. Mornex (CHUV: University Hospital of Lausanne)
Last. Nicolas GirardH-Index: 54
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#1Kate Haslett (University of Manchester)H-Index: 6
#2N. BaymanH-Index: 3
Last. Corinne Faivre-Finn (University of Manchester)H-Index: 50
view all 13 authors...
Purpose Not all patients with stage III non-small cell lung cancer (NSCLC) are suitable for concurrent chemoradiation therapy (CRT). Local failure rate is high for sequential concurrent CRT. As such, there is a rationale for treatment intensification. Methods and Materials Isotoxic intensity modulated radiation therapy (IMRT) is a multicenter feasibility study that combines different intensification strategies including hyperfractionation, acceleration, and dose escalation facilitated by IMRT. P...
#1Cathryn CrockettH-Index: 1
#2Pamela SamsonH-Index: 16
Last. David CobbenH-Index: 13
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Curative-intent radiotherapy plays an integral role in the treatment of lung cancer and therefore improving its therapeutic index is vital. MR guided radiotherapy (MRgRT) systems are the latest technological advance which may help with achieving this aim. The majority of MRgRT treatments delivered to date have been stereotactic body radiation therapy (SBRT) based and include the treatment of (ultra-) central tumors. However, there is a move to also implement MRgRT as curative-intent treatment fo...
#1Matthew Evison (University of Manchester)H-Index: 13
#2E. Barrett (University of Manchester)
Last. Corinne Faivre-Finn (University of Manchester)H-Index: 50
view all 23 authors...
Abstract Aims There is a paucity of evidence on which to produce recommendations on neither the clinical nor the imaging follow-up of lung cancer patients after curative-intent radiotherapy. In the 2019 National Institute for Health and Care Excellence lung cancer guidelines, further research into risk-stratification models to inform follow-up protocols was recommended. Materials and methods A retrospective study of consecutive patients undergoing curative-intent radiotherapy for non-small cell ...
#1Simon Bach (University of Birmingham)H-Index: 18
#2Alexandra Gilbert (University of Leeds)H-Index: 10
Last. Tijani UmarH-Index: 1
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Summary Background Radical surgery via total mesorectal excision might not be the optimal first-line treatment for early-stage rectal cancer. An organ-preserving strategy with selective total mesorectal excision could reduce the adverse effects of treatment without substantially compromising oncological outcomes. We investigated the feasibility of recruiting patients to a randomised trial comparing an organ-preserving strategy with total mesorectal excision. Methods TREC was a randomised, open-l...
5 CitationsSource
#1Sanjay Popat (ICR: Institute of Cancer Research)H-Index: 48
#2Neal Navani (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 24
Last. Fiona McDonald (ICR: Institute of Cancer Research)H-Index: 20
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Non-small cell lung cancer (NSCLC) accounts for approximately one in five cancer-related deaths, and management requires increasingly complex decision making by health care professionals. Many centers have therefore adopted a multidisciplinary approach to patient care, using the expertise of various specialists to provide the best evidence-based, personalized treatment. However, increasingly complex disease staging, as well as expanded biomarker testing and multimodality management algorithms wi...