Gang Fan
Chengdu University of Traditional Chinese Medicine
Infrared spectroscopyHigh-performance liquid chromatographyChemistryMetabolomicsPrincipal component analysisInsulin resistanceCoptis chinensisMagnoflorinePalmatineJatrorrhizineBerberineIridoid GlycosidesTraditional Tibetan MedicineTibetan medicineChromatographyDiabetes mellitusTraditional medicineComputational biologyMedicineBiologyPharmacology
52Publications
9H-index
233Citations
Publications 51
Newest
#1Huan Yi (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 2
Last. Gang Fan (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 9
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Metabolic diseases have become major public health issues worldwide. Searching for effective drugs for treating metabolic diseases from natural compounds has attracted increasing attention. Quercetin, an important natural flavonoid, is extensively present in fruits, vegetables, and medicinal plants. Due to its potentially beneficial effects on human health, quercetin has become the focus of medicinal attention. In this review, we provide a timely and comprehensive summary of the pharmacological ...
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#1Cheng-Cheng Zhao (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 2
#2Xin-Yue Wu (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 2
Last. Gang Fan (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 9
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Salidroside (SAL) is the main active ingredient of the plateau plant Rhodiola. So far, many animal experiments proved that SAL has good biological activity against some metabolic and cardiovascular diseases. However, most of these reports are scattered. This review systematically summarizes the pharmacological progress of SAL in the treatment of several metabolic (e.g., diabetes and non-alcoholic fatty liver disease) and cardiovascular (e.g., atherosclerosis) diseases in a timely manner to promo...
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#1Yunsen Zhang (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 2
#2Zikuang Zhao (CDUTCM: Chengdu University of Traditional Chinese Medicine)
Last. Yi Zhang (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 13
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Smilax china L. (SCL) is extensively used in the treatment of pelvic inflammatory disease (PID). This study aimed to clarify the potential active ingredients of SCL and mechanisms on PID. SCL was widely distributed in Japan, South Korea, and China, which was traditionally considered heat-clearing, detoxicating, and dampness-eliminating medicine. Systems pharmacology revealed that 32 compounds in SCL may interact with 19 targets for immunoenhancement, antiapoptosis, anti-inflammation, and antioxi...
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#1Tong Xu (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 4
#2Yi‐Man Ge (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 1
Last. Yi Zhang (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 13
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Abstract Background The stem bark of Berberis kansuensis Schneid (BK) is a commonly used Tibetan medicine for the treatment of type 2 diabetes (T2D). However, its therapeutic mechanisms remain unclear. Aim of the study Our aim is to clarify the role of gut microbiota in the anti-diabetic activity of BK extract. Materials and methods High fat diet combined with low-dose streptozotocin (45 mg/kg) was used to establish a T2D rat model, and the body weight of rats was measured every five days. Fasti...
1 CitationsSource
#1Guangli Liu (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 1
#2Guangmin Tang (Sichuan University)H-Index: 1
Last. Mingming Zhao (CDUTCM: Chengdu University of Traditional Chinese Medicine)
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By measuring the cerebral infarction rate and neurological behavioral score of rats in a sham operation group, an MCAO model control group and an Erigeron breviscapus injection treatment group, we explored the therapeutic effects of Erigeron breviscapus injection on brain tissue and neuroethological injury in rats. Plasma samples were collected at 18 time points after intravenous injection of Erigeron breviscapus. The levels of scutellarin, 4-caffeoylquinic acid, 5-caffeoylquinic acid, 3,5-dicaf...
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#1Xinmei Xu (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 3
#2Huan Yi (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 2
Last. Gang Fan (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 9
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The increased incidence of metabolic diseases (e.g., diabetes and obesity) has seriously affected human health and life safety worldwide. It is of great significance to find effective drugs from natural compounds to treat metabolic diseases. Berberine (BBR), an important quaternary benzylisoquinoline alkaloid, exists in many traditional medicinal plants. In recent years, BBR has received widespread attention due to its good potential in the treatment of metabolic diseases. In order to promote th...
4 CitationsSource
#1Ce Tang (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 5
#2Jian Wen (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 3
Last. Yi Zhang (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 13
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Abstract Identification of Rhodiola species was the key to ensure the clinical application of Rhodiola, especially in the dried and powdered forms, owing to different Rhodiola species having important differences in the quality and physiological activity of medicinal materials. In this study, multi-step IR spectroscopy combined with multivariate data analysis was employed to establish a nondestructive, fast, and efficient Rhodiola classification method. A total of 31 batches of powder spectra we...
1 CitationsSource
#1Huan Du (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 4
#2Qi Li (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 7
Last. Gang Fan (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 9
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The dried stem bark of Berberis kansuensis C.K.Schneid. (Berberidaceae) was widely used to treat diabetes in traditional Tibetan medicine system. However, its anti-diabetic mechanisms have not been elucidated. In this study, 1 H-NMR-based metabolomics combined with biochemistry assay was applied to investigate the anti-diabetic activities as well as underlying mechanisms of B. kansuensis extract on type 2 diabetic rats. The results showed that after 30 days treatment with B. kansuensis extract, ...
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#1Ce Tang (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 5
#2Cheng-Cheng Zhao (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 2
Last. Gang Fan (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 9
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Cancer is a leading cause of death around the world. Apoptosis, one of the pathways of programmed cell death, is a promising target for cancer therapy. Traditional Tibetan medicine (TTM) has been used by Tibetan people for thousands of years, and many TTMs have been proven to be effective in the treatment of cancer. This paper summarized the medicinal plants with anticancer activity in the Tibetan traditional system of medicine by searching for Tibetan medicine monographs and drug standards, and...
2 CitationsSource
#1Qi Li (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 7
#2Cheng-Cheng Zhao (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 2
Last. Yi Zhang (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 13
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The dried stem bark of Berberis vernae C.K.Schneid., known as "Xiao-bo-pi" in Chinese, is a representative anti-diabetic herb in traditional Tibetan medical system. However, its anti-diabetic mechanisms and active components remain unclear. In this study, 1H NMR-based metabolomics, biochemistry assay, molecular docking, and network analysis were integrated to evaluate the anti-diabetic effects of B. vernae extract on type 2 diabetic rats, and to explore its active components and underlying mecha...
2 CitationsSource