K. Panduranga Rao
Central Leather Research Institute
Vinyl polymerSelf-healing hydrogelsDrug carrierNuclear chemistryCopolymerMonomerOrganic chemistryAqueous solutionChemistryParticle sizePolymer chemistryMaterials scienceSide chainGraftingMethyl methacrylateSwellingGelatinDrug deliveryChemical engineeringPolymerizationPolymerDosage form
25Publications
13H-index
853Citations
Publications 25
Newest
#1R. Jeyanthi (CLRI: Central Leather Research Institute)H-Index: 1
#2B. Nagarajan (CLRI: Central Leather Research Institute)H-Index: 1
Last. K. Panduranga Rao (CLRI: Central Leather Research Institute)H-Index: 13
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— Implantable collagen-poly(HEMA) hydrogels containing the anticancer drug 5-fluorouracil (5-FU) have been prepared and evaluated for their efficacy towards a solid tumour fibrosarcoma in Wistar rats. The tumour was developed by inoculation of a 10% tumour-cell suspension in the anterior aspect of the hind limb. Four groups were studied—untreated control, intratumoural injection of free 5-FU, subcutaneous implantation of placebo and implantation of 5-FU-bearing hydrogel pellets (10 mm diameter ×...
30 CitationsSource
#1R. Murugan (CLRI: Central Leather Research Institute)H-Index: 1
#2K. Panduranga Rao (CLRI: Central Leather Research Institute)H-Index: 13
Demineralized xenogeneic bone (DXB) was prepared from bovine cortical tibia and graft copolymerized with glycidylmethacrylate (GMA) using a combination of potassium persulfate (K 2 S 2 O 8 ) and sodium metabisulfite (Na 2 S 2 O 5 )as redox initiating system in aqueous medium. To optimize the reaction condition, the concentrations of backbone, monomer, initiator, temperature and time were varied. The percent grafting was found to increase initially and thereafter decrease in most of the cases. Th...
5 CitationsSource
#1M. Sivakumar (CLRI: Central Leather Research Institute)H-Index: 1
#2K. Panduranga Rao (CLRI: Central Leather Research Institute)H-Index: 13
Abstract Composite microspheres have been prepared from bioactive ceramics such as coralline hydroxyapatite [CHA, Ca 10 (PO 4 ) 6 (OH) 2 ] granules, a biodegradable polymer, gelatin and an antibiotic, gentamicin. In our earlier work, we have shown a gentamicin release from CHA granules—chitosan composite microspheres. In the present investigation, an attempt was made to prepare the composite microspheres containing coralline hydroxyapatite and gelatin (CHA–G), which were prepared by the dispersi...
223 CitationsSource
#1Muthusamy Sivakumar (CLRI: Central Leather Research Institute)H-Index: 26
#2K. Panduranga Rao (CLRI: Central Leather Research Institute)H-Index: 13
This article describes the development of a new crosslinked poly(methyl methacrylate-2-hydroxyethyl methacrylate) copolymeric core–shell hydrogel microsphere incorporated with ibuprofen for potential applications in bone implants. Initially poly(methyl methacrylate) (PMMA) core microspheres were prepared by free-radical initiation technique. On these core microspheres, 2-hydroxyethyl methacrylate (HEMA) was polymerized by swelling PMMA microspheres with the HEMA monomer by using ascorbic acid an...
57 CitationsSource
#1N Shanmugasundaram (CLRI: Central Leather Research Institute)H-Index: 1
#2P Ravichandran (CLRI: Central Leather Research Institute)H-Index: 3
Last. K. Panduranga Rao (CLRI: Central Leather Research Institute)H-Index: 13
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Abstract A biodegradable polymer scaffold was developed using collagen and chitosan, in the form of interpenetrating polymeric network (IPN), for in vitro culture of human epidermoid carcinoma cells (HEp-2, Cincinnati). Glutaraldehyde was used as cross-linking agent for the development of scaffold. Various types of scaffolds were prepared using different proportionate mixtures of collagen and chitosan solutions in the ratio of 3:7, 4:6, 5:5, 6:4 and 7:3 (collagen:chitosan). These scaffolds were ...
374 CitationsSource
#1A.B. Madhan Kumar (CLRI: Central Leather Research Institute)H-Index: 3
#2K. Panduranga Rao (CLRI: Central Leather Research Institute)H-Index: 13
Abstract Prot A7, a polypeptidic proteinoid composed of seven different amino acids, was synthesized and microspheres of 1–5 μm size were prepared by the self-assembly process. The morphological characterization of the microspheres was carried out using optical microscopy and SEM (scanning electron microscopy). Emphasis also has been made on studying the mechanism behind the microsphere formation and to relate it with the conformation of the polypeptide. These self-assembled microspheres were fo...
46 CitationsSource
#1P Ravichandran (CLRI: Central Leather Research Institute)H-Index: 3
#2K.L. Shantha (CLRI: Central Leather Research Institute)H-Index: 3
Last. K. Panduranga Rao (CLRI: Central Leather Research Institute)H-Index: 13
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Abstract The development of pH sensitive, biocompatible and biodegradable hydrogels as novel drug delivery systems was carried out to achieve localized drug delivery. Poly[ N -vinyl pyrrolidone-acrylic acid]-polyethylene glycol (Poly[NVP-AA]-PEG) interpolymer type systems were prepared by free radical polymerization. Azobisisobutyronitrile (AIBN) was used for initiating the polymerization and N , N ″-methylene bisacrylamide was employed as a crosslinking agent. The concentration of initiator and...
39 CitationsSource
#1A.B. Madhan Kumar (CLRI: Central Leather Research Institute)H-Index: 3
#2K. Panduranga Rao (CLRI: Central Leather Research Institute)H-Index: 13
Abstract A new type of carrier using poly(palmitoyl- l -hydroxyproline ester) (PPH) [IUPAC name: poly((1-palmitoyl-4,2-pyrrolidinediyl)carbonyloxy)], a poly(amino acid) is described. The polymer is synthesized by conventional method and the microspheres were prepared by solvent evaporation technique for application in drug delivery system. Microspheres with different sizes were prepared by varying certain formulation and technological parameters and their distributive stabilities under physiolog...
8 CitationsSource
#1A.B. Madhan Kumar (CLRI: Central Leather Research Institute)H-Index: 3
#2Rangasamy Jayakumar (CLRI: Central Leather Research Institute)H-Index: 79
Last. K. Panduranga Rao (CLRI: Central Leather Research Institute)H-Index: 13
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Polypeptide-based acidic proteinoid containing L-glutamic acid and L-aspartic acid in excess and five other neutral and basic amino acids in minor proportions have been synthesized and found that it forms organized aggregates in an aqueous solution. The proteinoid aggregate has been characterized using 13 C-NMR, IR, and fluorescence spectroscopic techniques. The c.m.c. of the proteinoid has been determined by conductometric and pH metric methods. The aggregation studies were carried out at diffe...
12 CitationsSource
#1K.L. Shantha (CLRI: Central Leather Research Institute)H-Index: 1
#2Udaya Bala (CLRI: Central Leather Research Institute)H-Index: 1
Last. K. Panduranga Rao (CLRI: Central Leather Research Institute)H-Index: 13
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Graft copolymers of chitosan were prepared using acrylic and methacrylic acids. The grafting was initiated by eerie ion. Experimental parameters such as the concentrations of monomer and the initiator on grafting were investigated. The percent grafting, grafting efficiency and percent conversion of the monomer were also analysed. The graft copolymers were further characterized by infrared spectroscopy and gravimetric analysis. These graft copolymers were subsequently utilized for the preparation...
62 CitationsSource