Susan C Short
University of Leeds
CancerInternal medicineRadiologyDNA repairSurgeryPathologyOncologymicroRNAChemistryImmunologyGlioblastomaTemozolomideGliomaStem cellNuclear medicineCancer researchRadiation therapyRadioresistanceMedicineCell cultureBiology
Publications 221
#1Kelly J. McKelvey (USYD: University of Sydney)H-Index: 8
#2E. Wilson (University of Leeds)
Last. Viive M. Howell (USYD: University of Sydney)H-Index: 18
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Glioblastoma is the most aggressive adult glioma with a median survival of 14 months. While standard treatments (safe maximal resection, radiation, temozolomide chemotherapy) have increased the median survival in favorable MGMT-methylated glioblastoma (namely ~21 months), a large proportion of patients experience a highly debilitating and rapidly fatal disease. This study examined glioblastoma cellular energetic pathways and blockade using repurposed drugs – the glycolytic inhibitor, dicholoroac...
#1Tereza Andreou (University of Leeds)H-Index: 4
#2Jennifer Williams (University of Leeds)H-Index: 6
Last. Mihaela Lorger (University of Leeds)H-Index: 16
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Patients with glioblastoma (GBM) have a poor prognosis, and inefficient delivery of drugs to tumors represents a major therapeutic hurdle. Hematopoietic stem cell (HSC)-derived myeloid cells efficiently home to GBM and constitute up to 50% of intratumoral cells, making them highly appropriate therapeutic delivery vehicles. Because myeloid cells are ubiquitously present in the body, we recently established a lentiviral vector containing matrix metalloproteinase 14 (MMP14) promoter, which is activ...
#1Michael Weller (UZH: University of Zurich)H-Index: 153
#2Martin J. van den Bent (EUR: Erasmus University Rotterdam)H-Index: 96
Last. Wolfgang Wick (University Hospital Heidelberg)H-Index: 121
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In response to major changes in diagnostic algorithms and the publication of mature results from various large clinical trials, the European Association of Neuro-Oncology (EANO) recognized the need to provide updated guidelines for the diagnosis and management of adult patients with diffuse gliomas. Through these evidence-based guidelines, a task force of EANO provides recommendations for the diagnosis, treatment and follow-up of adult patients with diffuse gliomas. The diagnostic component is b...
22 CitationsSource
#1Chris Twelves (University of Leeds)H-Index: 62
#2Michael Sabel (HHU: University of Düsseldorf)H-Index: 58
Last. Susan C Short (University of Leeds)H-Index: 34
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BACKGROUND Preclinical data suggest some cannabinoids may exert antitumour effects against glioblastoma (GBM). Safety and preliminary efficacy of nabiximols oromucosal cannabinoid spray plus dose-intense temozolomide (DIT) was evaluated in patients with first recurrence of GBM. METHODS Part 1 was open-label and Part 2 was randomised, double-blind, and placebo-controlled. Both required individualised dose escalation. Patients received nabiximols (Part 1, n = 6; Part 2, n = 12) or placebo (Part 2 ...
1 CitationsSource
#1Sharon Fernandez (Leeds Teaching Hospitals NHS Trust)
#2M. Beasley (Leeds Teaching Hospitals NHS Trust)H-Index: 1
Last. Susan C Short (Leeds Teaching Hospitals NHS Trust)H-Index: 34
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#1Susan C ShortH-Index: 34
#2Louise MurrayH-Index: 16
#1Jessica Kendall (University of Leeds)H-Index: 2
#2Anthony J. Chalmers (Glas.: University of Glasgow)H-Index: 32
Last. Susan C Short (University of Leeds)H-Index: 34
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#1Patrick Y. Wen (Brigham and Women's Hospital)H-Index: 118
#2Michael Weller (UZH: University of Zurich)H-Index: 153
Last. Martin J. van den Bent (EUR: Erasmus University Rotterdam)H-Index: 96
view all 40 authors...
Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society For Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase-w...
57 CitationsSource
#1Marjorie Boissinot (University of Leeds)H-Index: 14
#2Henry King (University of Leeds)H-Index: 2
Last. Susan C Short (University of Leeds)H-Index: 34
view all 21 authors...
MicroRNAs play an important role in the regulation of mRNA translation and have therapeutic potential in cancer and other diseases. To profile the landscape of microRNAs with significant cytotoxicity in the context of glioblastoma (GBM), we performed a high-throughput screen in adult and pediatric GBM cells using a synthetic oligonucleotide library representing all known human microRNAs. Bioinformatics analysis was used to refine this list and the top seven microRNAs were validated in a larger p...
#1Sophie Ketchen (University of Leeds)H-Index: 1
#2Arndt Rohwedder (University of Leeds)H-Index: 1
Last. Anke Brüning-Richardson (University of Huddersfield)H-Index: 10
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The limitations of two-dimensional analysis in three-dimensional (3D) cellular imaging impair the accuracy of research findings in biological studies. Here, we report a novel 3D approach to acquisi...
2 CitationsSource