Kazutaka Ouchi
Kyoto Prefectural University of Medicine
GeneFusion geneInternal medicineChromosomal translocationSurgeryPathologyGene knockdownSMARCB1ChemistryApoptosisImmunologySensitivity (control systems)VirusDiseaseLipoblastomaNeoplasmRhabdomyosarcomaMalignant rhabdoid tumorXIAP DeficiencyExonMutationCancer researchSequence analysisCell growthMedicineCell cultureBiologyGastroenterology
18Publications
6H-index
131Citations
Publications 18
Newest
Abstract Intraperitoneal venous malformations are uncommon; therefore, the prognosis of patients has not been determined and appropriate treatments have not been established. Here, we report a neonate with extensive intraperitoneal venous malformation. She did not have developmental disorder nor functional disability; thus, she was observed without treatment. However, the patient died suddenly of obstructive venous return disorder due to thrombosis in a vein draining from the venous malformation...
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#1Yasumichi Kuwahara (Kyoto Prefectural University of Medicine)H-Index: 11
#2Tomoko Iehara (Kyoto Prefectural University of Medicine)H-Index: 21
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 17 authors...
Background/aim Malignant rhabdoid tumor (MRT) is a rare, aggressive neoplasm found in young children, caused by inactivation of a single gene, SNF5 (INI1, SMARCB1). MRT cases with multifocal tumors at diagnosis are categorized as synchronous MRT, often with a germline mutation of SNF5. The aim of this study was to establish new models useful in clarifying the biological basis of synchronous MRT. Materials and methods We established two novel MRT cell lines, designated as KP-MRT-KS and KP-MRT-KSa...
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#1Yohei Sugimoto (Kyoto Prefectural University of Medicine)H-Index: 1
#2Yoshiki Katsumi (Kyoto Prefectural University of Medicine)H-Index: 8
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 14 authors...
Rhabdoid tumor is an aggressive, early childhood tumor. Biallelic inactivation of the SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1)/integrase interactor 1 (INI1) gene is the only common genetic feature in rhabdoid tumors. Loss of SMARCB1 function results in downregulation of several tumor suppressor genes including p16, p21, and NOXA. The novel histone deacetylase inhibitor, OBP-801, induces p21 and has shown efficacy against various canc...
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#1Kazutaka Ouchi (Kyoto Prefectural University of Medicine)H-Index: 6
#2Mitsuru Miyachi (Kyoto Prefectural University of Medicine)H-Index: 11
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 8 authors...
Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. There are two subtypes, fusion gene-positive RMS (FP-RMS) and fusion gene-negative RMS (FN-RMS), depending on the presence of a fusion gene, either PAX3-FOXO1 or PAX7-FOXO1. These fusion genes are thought to be oncogenic drivers of FP-RMS. By contrast, the underlying mechanism of FN-RMS has not been thoroughly investigated. It has recently been shown that HMGA2 is specifically positive in pathological tissue from FN-RMS, bu...
2 CitationsSource
#1Tomoko Iehara (Kyoto Prefectural University of Medicine)H-Index: 21
#2Shigeki Yagyu (Kyoto Prefectural University of Medicine)H-Index: 14
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 9 authors...
BACKGROUND: Our previous study reported a method for determining MYCN gene amplification (MNA) status using cell-free DNA in serum. We prospectively analyzed the serum MNA status using sera obtained before the initial diagnosis from patients with neuroblastoma and evaluated the utility of this method. METHODS: Eighty patients were enrolled in the study. The serum MYCN/NAGK ratio was assessed for all cases. RESULTS: Fifteen cases showed serum MNA, while 65 did not. Of the 80 total patients, tumor...
3 CitationsSource
#1Yoshihiro Nitta (Kyoto Prefectural University of Medicine)H-Index: 2
#2Mitsuru Miyachi (Kyoto Prefectural University of Medicine)H-Index: 11
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 13 authors...
Abstract Lipoblastoma is a rare benign adipose tissue tumor that occurs mostly in infants and children. Histological diagnosis of lipoblastoma is sometimes difficult because it closely resembles other lipomatous tumors. The detection of PLAG1 gene rearrangement is useful for the diagnosis of lipoblastoma. Four PLAG1 fusion partner genes are known in lipoblastoma: HAS2 at 8q24.1, COL1A2 at 7q22, COL3A1 at 2q32, and RAB2A at 8q12. Herein, we describe a novel fusion gene in a case of lipoblastoma o...
9 CitationsSource
#1Hiroshi Kubo (Kyoto Prefectural University of Medicine)H-Index: 1
#2Kazutaka Ouchi (Kyoto Prefectural University of Medicine)H-Index: 6
Last. Shinji Akioka (Kyoto Prefectural University of Medicine)H-Index: 5
view all 4 authors...
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Inflammatory myofibroblastic tumor (IMT), which expresses cyclooxygenase-2 (COX-2), can be effectively treated with COX-2 inhibitor. Here, we report a case of urinary bladder IMT in a 13-year-old boy. Although total cystectomy was initially planned for complete resection of the tumor, neoadjuvant treatment with COX-2 inhibitor and prednisolone reduced the size of the tumor and enabled complete resection of the tumor by partial cystectomy. Neoadjuvant treatment with COX-2 inhibitor and prednisolo...
2 CitationsSource
#1Kazutaka Ouchi (Kyoto Prefectural University of Medicine)H-Index: 6
#2Yasumichi Kuwahara (Kyoto Prefectural University of Medicine)H-Index: 11
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 9 authors...
Malignant rhabdoid tumor (MRT) is a rare aggressive pediatric cancer characterized by inactivation of SNF5, a core subunit of SWI/SNF complexes. Previously, we showed that SNF5 contributes to transcriptional activation of NOXA, a pro-apoptotic protein that binds and inhibits the anti-apoptotic protein MCL-1. In this study, we found that NOXA expression was downregulated in MRT cell lines as well as in clinical MRT samples and that ectopically expressed NOXA bound MCL-1 and increased the sensitiv...
6 CitationsSource
#1Shinichi Tamura (Memorial Hospital of South Bend)H-Index: 8
#2Hiroyuki Ishida (Kyoto Prefectural University of Medicine)H-Index: 16
Last. Toshihiko Imamura (Kyoto Prefectural University of Medicine)H-Index: 22
view all 10 authors...
Here we report a case of aggressive neuroendocrine tumor (NET), which is an extremely rare secondary solid tumor that occurs after allogeneic hematopoietic cell transplantation (allo-HSCT). A patient with chronic active Epstein-Barr virus infection received allo-HSCT from an HLA-DR two allele-mismatched unrelated donor. Four years later, he developed NET with multiple metastases. He received thoraco-abdominal irradiation as a conditioning regimen, and developed repeated episodes of intestinal gr...
1 CitationsSource