John H. Stone
Harvard University
Internal medicineSurgeryPathologyAntibodyDermatologyImmunologyAnti-neutrophil cytoplasmic antibodyVasculitisGiant cell arteritisTocilizumabPrednisoneMicroscopic polyangiitisDiseaseIgG4-related diseaseFibrosisRituximabGranulomatosis with polyangiitisPopulationMedicineGastroenterology
541Publications
94H-index
29.2kCitations
Publications 529
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#1Sebastian Unizony (Harvard University)H-Index: 18
#2Min Bao (Genentech)H-Index: 11
Last. John H. Stone (Harvard University)H-Index: 94
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OBJECTIVE Identify predictors of treatment failure in patients with giant cell arteritis (GCA) receiving tocilizumab in combination with glucocorticoids and in patients with GCA receiving only glucocorticoids. METHODS Posthoc analysis of the Giant-Cell Arteritis Actemra trial including 250 patients who received tocilizumab every week plus a 26-week prednisone taper (n=100), tocilizumab every-other-week plus a 26-week prednisone taper (n=49) or placebo plus a 26-week (n=50) or 52-week (n=51) pred...
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#1Justin A. Jarrell (Stanford University)H-Index: 11
#1Justin A. Jarrell (VA Palo Alto Healthcare System)
Last. William H. Robinson (Stanford University)H-Index: 76
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Abstract Background IgG4-related disease (IgG4-RD) is a fibro-inflammatory condition involving loss of B cell tolerance and production of autoantibodies. However, the relevant targets and role of these aberrant humoral immune responses are not defined. Objective To identify novel autoantibodies and autoantigen targets that promote pathogenic responses in IgG4-RD. Methods We sequenced plasmablast antibody repertoires in patients with IgG4-RD. Representative monoclonal antibodies (mAb) were expres...
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#1John H. Stone (Harvard University)H-Index: 94
#2Jian Han (Genentech)H-Index: 4
Last. Min Bao (Genentech)H-Index: 11
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Summary Background The combination of tocilizumab plus a glucocorticoid taper is effective in maintaining clinical remission without requiring additional glucocorticoid therapy in patients with giant cell arteritis, as shown in part one of the Giant Cell Arteritis Actemra (GiACTA) trial. However, the duration of the tocilizumab effect after discontinuation is unknown. Here, we explored the maintenance of efficacy 1 year after discontinuation of tocilizumab treatment, the effectiveness of retreat...
1 CitationsSource
#1Robert Spiera (HSS: Hospital for Special Surgery)H-Index: 45
#2Sebastian Unizony (Harvard University)H-Index: 18
Last. John H. Stone (Harvard University)H-Index: 94
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Abstract Objective The randomized, placebo (PBO)–controlled GiACTA trial demonstrated the efficacy and safety of tocilizumab (TCZ) in patients with giant cell arteritis (GCA). The present study evaluated the efficacy of TCZ in patients with GCA presenting with polymyalgia rheumatica (PMR) symptoms only, cranial symptoms only or both PMR and cranial symptoms in the GiACTA trial. Methods In GiACTA, 250 patients with GCA received either TCZ weekly or every other week plus a 26-week prednisone taper...
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#1Rachel Wallwork (Harvard University)H-Index: 6
#2Cory A. Perugino (Harvard University)H-Index: 14
Last. Zachary S. Wallace (Harvard University)H-Index: 27
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Objective To evaluate the association between cigarette smoking and the odds of IgG4-related disease (IgG4-RD). Methods We performed a case-control study of patients with IgG4-RD, compared in a 1:5 ratio with age-, race- and sex-matched controls. We included cases evaluated at Massachusetts General Hospital, a hospital within the Mass General Brigham (MGB) System. Controls were identified from the MGB Biobank. Smoking status at date of IgG4-RD diagnosis or corresponding index date was determined...
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#1Damian R. Plichta (Broad Institute)H-Index: 14
#2Juhi Somani (Aalto University)H-Index: 2
Last. Ramnik J. Xavier (Broad Institute)H-Index: 144
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BACKGROUND Immunoglobulin G4-related disease (IgG4-RD) and systemic sclerosis (SSc) are rare autoimmune diseases characterized by the presence of CD4+ cytotoxic T cells in the blood as well as inflammation and fibrosis in various organs, but they have no established etiologies. Similar to other autoimmune diseases, the gut microbiome might encode disease-triggering or disease-sustaining factors. METHODS The gut microbiomes from IgG4-RD and SSc patients as well as healthy individuals with no rece...
1 CitationsSource
#1Liqin Wang (Harvard University)H-Index: 7
#2Eli M. Miloslavsky (Harvard University)H-Index: 15
Last. Zachary S. Wallace (Harvard University)H-Index: 27
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Abstract Objectives Clinical notes from electronic health records (EHR) are important to characterize the natural history, comorbidities, and complications of ANCA-associated vasculitis (AAV) because these details may not be captured by claims and structured data. However, labor-intensive chart review is often required to extract information from notes. We hypothesized that machine learning can automatically discover clinically-relevant themes across longitudinal notes to study AAV. Methods This...
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