John H. Stone
Harvard University
Internal medicineSurgeryPathologyAntibodyDermatologyImmunologyAnti-neutrophil cytoplasmic antibodyVasculitisGiant cell arteritisTocilizumabPrednisoneMicroscopic polyangiitisDiseaseIgG4-related diseaseFibrosisRituximabGranulomatosis with polyangiitisPopulationMedicineGastroenterology
530Publications
76H-index
26.8kCitations
Publications 563
Newest
#1Robert Spiera (HSS: Hospital for Special Surgery)H-Index: 41
#2Sebastian Unizony (Harvard University)H-Index: 17
Last. John H. Stone (Harvard University)H-Index: 76
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Abstract Objective The randomized, placebo (PBO)–controlled GiACTA trial demonstrated the efficacy and safety of tocilizumab (TCZ) in patients with giant cell arteritis (GCA). The present study evaluated the efficacy of TCZ in patients with GCA presenting with polymyalgia rheumatica (PMR) symptoms only, cranial symptoms only or both PMR and cranial symptoms in the GiACTA trial. Methods In GiACTA, 250 patients with GCA received either TCZ weekly or every other week plus a 26-week prednisone taper...
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#1Rachel Wallwork (Harvard University)H-Index: 6
#2Cory A. Perugino (Harvard University)H-Index: 13
Last. Zachary S. Wallace (Harvard University)H-Index: 25
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#1Damian R. Plichta (Broad Institute)H-Index: 14
#2Juhi Somani (Aalto University)H-Index: 2
Last. Ramnik J. Xavier (Broad Institute)H-Index: 124
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BACKGROUND Immunoglobulin G4-related disease (IgG4-RD) and systemic sclerosis (SSc) are rare autoimmune diseases characterized by the presence of CD4+ cytotoxic T cells in the blood as well as inflammation and fibrosis in various organs, but they have no established etiologies. Similar to other autoimmune diseases, the gut microbiome might encode disease-triggering or disease-sustaining factors. METHODS The gut microbiomes from IgG4-RD and SSc patients as well as healthy individuals with no rece...
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#1Liqin Wang (Harvard University)H-Index: 6
#2Eli M. Miloslavsky (Harvard University)H-Index: 14
Last. Zachary S. Wallace (Harvard University)H-Index: 25
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Abstract Objectives Clinical notes from electronic health records (EHR) are important to characterize the natural history, comorbidities, and complications of ANCA-associated vasculitis (AAV) because these details may not be captured by claims and structured data. However, labor-intensive chart review is often required to extract information from notes. We hypothesized that machine learning can automatically discover clinically-relevant themes across longitudinal notes to study AAV. Methods This...
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Last. John H. Stone (Harvard University)H-Index: 76
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#1Zachary S. WallaceH-Index: 25
#2Huifeng YunH-Index: 29
Last. Hyon K. ChoiH-Index: 91
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Objective ANCA-associated vasculitis (AAV) management has evolved substantially over the last two decades. We sought to characterize AAV treatment patterns in the United States. Methods We identified AAV patients in the Rheumatology Informatics System for Effectiveness (RISE) registry who had at least two rheumatology clinician visits between January 1st, 2015 and December 31st, 2017. Demographics, medications, laboratory test results, and billing codes were extracted from the medical record. De...
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#1Brittany Weber (Brigham and Women's Hospital)H-Index: 6
#2Guohai Zhou (Brigham and Women's Hospital)H-Index: 12
Last. Ann E. Woolley (Brigham and Women's Hospital)H-Index: 10
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#1Lucrezia Rovati (UniSR: Vita-Salute San Raffaele University)H-Index: 6
#2Naoki Kaneko (Ragon Institute of MGH, MIT and Harvard)H-Index: 10
Last. Emanuel Della-Torre (UniSR: Vita-Salute San Raffaele University)H-Index: 25
view all 13 authors...
OBJECTIVES IgG4-related disease (IgG4-RD) is a systemic fibro-inflammatory disorder characterized by a dysregulated resolution of inflammation and wound healing response that might develop after an apoptotic insult induced by cytotoxic T lymphocytes (CTLs). Mer receptor tyrosine kinase (MerTK) and its ligand Protein S (ProS1) have a pivotal role in the resolution of inflammation, being implicated in the clearance of apoptotic cells, quenching of the immune response and development of tissue fibr...
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#1Sebastian Unizony (Harvard University)H-Index: 17
#2Timothy J. McCulley (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 17
Last. John H. Stone (Harvard University)H-Index: 76
view all 9 authors...
BACKGROUND Placebo-controlled clinical trials have demonstrated the efficacy of tocilizumab (TCZ) for remission maintenance and glucocorticoid sparing in patients with giant cell arteritis (GCA). However, limited data exist on the effectiveness and safety of TCZ for GCA in real-world clinical practice. METHODS This was a retrospective, single-center analysis of patients with GCA treated with intravenous or subcutaneous TCZ (2010-2018). Outcomes evaluated before and after TCZ initiation included ...
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