Peng-Fei Tu
Peking University
PharmacognosyMass spectrometryOrganic chemistryHigh-performance liquid chromatographyChemistryApoptosisGlycosidePhytochemicalTwo-dimensional nuclear magnetic resonance spectroscopyChemical constituentsChromatographyNitric oxideBiochemistryTraditional medicineBotanySignal transductionStereochemistryMedicineBiologyCell biologyPharmacology
493Publications
54H-index
7,546Citations
Publications 478
Newest
#1Juan Zhang (PKU: Peking University)H-Index: 2
#2Lun-Yong Shi (PKU: Peking University)H-Index: 1
Last. Qingying Zhang (PKU: Peking University)H-Index: 16
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Abstract null null Seven undescribed condensation derivatives of 4-isopropylbenzaldehyde with acetophenone, including one 1,3,5-trisubstituted pentane-1,5-dione, two 1,3,4,5,7-pentasubstituted heptane-1,7-diones and four 1,2,3,4,5-pentasubstituted cyclohexanols, together with two known flavonoids, were obtained from the red alga Laurencia tristicha. The relative configurations were elucidated by extensive spectroscopic data analysis of MS, 1D and 2D NMR, while the absolute configurations were de...
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#1Jiazhen Wang (Qilu University of Technology)
#2Cailian Mo (Qilu University of Technology)
Last. Kechun Liu (Qilu University of Technology)H-Index: 11
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Abstract null null Background: Zishen Guchong Pill (ZGP), a traditional oriental herbal medicine, has been applied broadly in the treatment of threatened or recurrent miscarriages in clinics, but little is known about its developmental toxicity. null Aim of the study: This study aimed to investigate the potential toxicity of ZGP and its mechanisms. null methods: We investigated the developmental toxicity of ZGP using a zebrafish model. Zebrafish embryos at 4 hours post-fertilization (hpf) were e...
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#1Xiaoli MaH-Index: 7
Last. Yong JiangH-Index: 31
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Seventeen new carbazole alkaloid derivatives, including a trimeric carbazole racemate, (±)-microphyltrine A (1), 15 dimeric carbazole racemates, (±)-microphyldines A–O (2–16), and a C-6–C-3″-methyl-linked dimeric carbazole, microphyldine P (17), were isolated from the leaves and stems of Murraya microphylla (Merr. et Chun) Swingle. The structures of the new compounds were elucidated on the basis of HRESIMS and NMR data analysis. The optically pure isomers of these isolated carbazole alkaloids we...
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#2Tian Lv (PKU: Peking University)H-Index: 1
Last. Xiaoni Ai (PKU: Peking University)H-Index: 2
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Drug-induced liver injury (DILI) is a leading cause of therapy failure in the clinic and also contributes much to acute liver failure cases. Investigations of predictive sensitivity in animal models have limitations due to interspecies differences. Previously reported in vitro models of liver injury based on primary human hepatocytes (PHHs) cannot meet the requirements of high physiological fidelity, low cost, simple operation and high throughput with improved sensitivity. Herein, we developed a...
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#1Jing Sun (Beijing University of Chinese Medicine)H-Index: 10
#2Jia-Ni LiuH-Index: 2
Last. Jun Li (Beijing University of Chinese Medicine)H-Index: 58
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Longxue Tongluo Capsules(LTC) has good efficacy against blood stasis syndrome during the recovery period of ischemic stroke. Its main active ingredient is the phenolic extract of Chinese dragon's blood. In our previous study, the primary mass fragmentation pathways of phenolic derivatives from LTC were clarified. Herein, the metabolites in rat plasma were characterized following the oral administration of loureirin A and loureirin C using liquid chromatography coupled with hybrid ion trap/time-o...
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#1Kannan Maharajan (Qilu University of Technology)H-Index: 6
#2Qing Xia (Qilu University of Technology)H-Index: 4
Last. Kechun Liu (Qilu University of Technology)H-Index: 11
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Abstract null null Ethnopharmacological relevance null Zishen Yutai Pill (ZYP) is a widely used Traditional Chinese Medicine in Assisted Reproductive Technology (ART) medications, particularly in China. ZYP has a potential therapeutic role in human reproductive health, including in vitro fertilization embryo transfer and various reproductive disorders. The National Essential Medicine List of China has recently included the ZYP in Obstetrics and Gynecology medicine due to its significance in trea...
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#1Mengqiu Lu (PKU: Peking University)H-Index: 1
#2Zhiyong Du (PKU: Peking University)H-Index: 4
Last. Yong Jiang (PKU: Peking University)H-Index: 31
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Abstract null null Ethnopharmacological relevance null Multi-source phenomenon is very common for traditional Chinese medicine (TCM). Both Murraya exotica L. (ME) and Murraya paniculata (L.) Jack (MP) are used as the source plants of Murrayae Folium et Cacumen (MFC), a traditional Chinese medicine recorded in Chinese Pharmacopoeia for promoting qi and relieving pain, mainly for the treatment of stomach pain, rheumatism and arthralgia. However, up to now, there has been no comparative study of th...
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#1Hui Meng (Beijing University of Chinese Medicine)H-Index: 5
#2Zhiyong Du (Capital Medical University)H-Index: 1
Last. Peng-Fei Tu (PKU: Peking University)H-Index: 54
view all 9 authors...
Abstract null null Background null The pathological cardiac functions of ankyrin repeat domain 1 (ANKRD1) in left ventricle can directly aggravate cardiac hypertrophy (CH) and fibrosis through the activation of extracellular signal-regulated kinase (ERK)/ transcription factor GATA binding protein 4 (GATA4) pathway, and subsequently contribute to heart failure (HF). Baoyuan Decoction (BYD), which is a famous classic Chinese medicinal formulation, has shown impressive cardioprotective effects clin...
1 CitationsSource
#1Yan-Yi Li (Beijing University of Chinese Medicine)
#2Jun-Jun Li (Beijing University of Chinese Medicine)H-Index: 3
Last. Xingyun Chai (Beijing University of Chinese Medicine)H-Index: 15
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Cardiovascular diseases seriously endanger human health and life. The accompanying myocardial injury has been a focus of attention in society. Chinese medicine,serving as a natural and precious reservoir for the research and development of new drugs,is advantageous in resisting myocardial injury due to its multi-component,multi-pathway,and multi-target characteristics. In recent years,with the extensive application of culture method for isolated cardiomyocytes,a cost-effective,controllable in vi...
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#1Zhiyong Du (PKU: Peking University)H-Index: 4
#2Ying-Yuan Lu (PKU: Peking University)H-Index: 4
Last. Yong Jiang (PKU: Peking University)H-Index: 31
view all 12 authors...
Abstract Multicomponent herbal formulas (MCHFs) have earned a wide reputation for their definite efficacy in preventing or treating chronic complex diseases. However, holistic elucidation of the causal relationship between the bioavailable ingredients of MCHFs and their multitarget interactions is very challenging. To solve this problem, pharmacokinetics/pharmacometabolomics-pharmacodynamics (PK/PM-PD) combined with a multivariate biological correlation-network strategy was developed and applied...
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