Xiu-Wei Yang
Peking University
PharmacokineticsPharmacognosyOrganic chemistryHigh-performance liquid chromatographyChemistryCaco-2GlycosideIn vitroIn vivoOral administrationGinsengBiotransformationIntestinal absorptionTandem mass spectrometryElectrospray ionizationChromatographyNitric oxideBiochemistryTraditional medicineMetabolismStereochemistryMedicineBiologyPharmacology
Publications 204
#1Yuqing Sun (PKU: Peking University)H-Index: 2
#2Xin Zhang (PKU: Peking University)
Last. Xiu-Wei Yang (PKU: Peking University)H-Index: 24
view all 6 authors...
Abstract null null Escin is a natural mixture of triterpene saponins, exhibits anti-oedematous properties and promotes venous drainage by oral administration or injection. Upon clinical application of escin, adverse kidney reactions have been reported and the nephrotoxic mechanism responsible for this reaction remains elusive. In the present study, four isomeric escins (β-form: escin Ia and escin Ib; α-form: isoescin Ia and isoescin Ib) were found severely decreasing the cell viability of human ...
#1Xiaoyan Liu (PKU: Peking University)H-Index: 19
#2You-Bo Zhang (PKU: Peking University)H-Index: 9
Last. Kai-Feng PengH-Index: 2
view all 9 authors...
#1Zheng Zhao (PKU: Peking University)H-Index: 4
#2Suixin Dong (PKU: Peking University)H-Index: 1
Last. Xuemin Zhang (PKU: Peking University)H-Index: 3
view all 0 authors...
Objective: To investigate the causes,prevention and treatment of femoral artery puncture related complications caused by the application of resuscitative endovascular balloon occlusion of the aorta (REBOA) in the resection of pelvic and sacral tumors. Methods: Clinical data of 23 patients with femoral artery puncture related complications who received REBOA in the resection of pelvic and sacral tumors from August 2010 to August 2018 at the Musculoskeletal Tumor Center,Peking University People's ...
#1Yuan Yuan (Harvard University)H-Index: 32
#1Yuan Y (Harvard University)
Last. Chao Tang (PKU: Peking University)H-Index: 53
view all 6 authors...
iCasp9 suicide gene has been widely used as a promising killing strategy in various cell therapies. However, different cells show significant heterogeneity in response to apoptosis inducer, posing challenges in clinical applications of killing strategy. The cause of the heterogeneity remains elusive so far. Here, by simultaneously monitoring the dynamics of iCasp9 dimerization, Caspase3 activation and cell fate in single cells, we found that the heterogeneity was mainly due to cell-to-cell varia...
#1Aneesh Bapat (Harvard University)H-Index: 8
Last. David J. MilanH-Index: 55
view all 13 authors...
Rationale: Given its rising prevalence in both the adult and pediatric populations, obesity has become an increasingly important risk factor in the development of atrial fibrillation. However, a better mechanistic understanding of obesity-related atrial fibrillation is required. Serum glucocorticoid kinase 1 (SGK1) is a kinase positioned downstream of multiple obesity-related pathways, and prior work has shown a pathologic role for SGK1 signaling in ventricular remodeling and arrhythmias. Object...
#1Lu Liu (PKU: Peking University)H-Index: 2
#2Shi Wang (PKU: Peking University)
Last. Xiu-Wei Yang (PKU: Peking University)H-Index: 24
view all 6 authors...
Si Shen Wan is a classic traditional Chinese medicine formula, which has been used to treat chronic colitis for thousands of years. Many research and experience show that Si Shen Wan was developed by the combination of two sets of "Herb Pairs", Er Shen Wan and Fructus Schisandrae Chinensis Powder. This research aimed to revealing the effective substances, guide the clinical treatment and represent the synergy effects from the view of pharmacokinetics. A UPLC-MS/MS method was established and vali...
#1Gai-Gai Deng (PKU: Peking University)H-Index: 4
#2Wei Xu (PKU: Peking University)H-Index: 124
Last. Xiu-Wei Yang (PKU: Peking University)H-Index: 24
view all 3 authors...
The absorption is the key to the resulted efficacy of orally administered drugs and the small intestine is the main site to absorb the orally administered drug. In this paper, internationally recognized human colon adenocarcinoma cell line(Caco-2) monola-yer model which can simulate small intestinal epithelial cell was used to comparatively study the absorption and transportation diffe-rences of total coumarins and main individual coumarin in Angelica dahurica 'Yubaizhi' by separately using 6-an...
#1Lu Liu (PKU: Peking University)H-Index: 2
#2Ze-Xu Cui (PKU: Peking University)H-Index: 2
Last. Yun GongH-Index: 4
view all 8 authors...
Abstract In this research, a comprehensive and innovative method was established for the qualitative and quantitative analysis of the main components in Mahonia fortune (MF). On the one hand, comprehensive insight of the constituents in MF extracts was achieved with a Q‑Exactive HF Mass Spectrometer using data-independent acquisition method. The identification of 17 compounds was based on comparison with authentic reference standards and the deduction of 119 additional compounds both in positive...
1 CitationsSource
#1Juanxia WuH-Index: 24
#2W. SunH-Index: 1
Last. Dongmei LinH-Index: 7
view all 12 authors...
#1Xiu-Wei Yang (PKU: Peking University)H-Index: 24
#2Wei Sun (PKU: Peking University)H-Index: 3
Last. Jinzhu Bai (PKU: Peking University)H-Index: 3
view all 5 authors...
OBJECTIVE To analyze the etiological and clinical characteristics of oral emergency patients under 18 years with dental trauma, and to provide guidance on the prevention and treatment in children and adolescents. METHODS A retrospective study on the intact data of the dental trauma patients under 18 years from January 2016 to December 2018 in the Department of Oral Emergency in Peking University School of Stomatology was conducted, and the distribution of the patients' gender, age and visiting t...