Chenxu Zhao
Jilin University
Caspase 3Internal medicineEndocrinologyTumor necrosis factor alphaKinaseChemistryApoptosisAutophagySuperoxide dismutaseOxidative stressKetosisButyrateMalondialdehydeLipopolysaccharideGlutathione peroxidaseFatty liverSignal transductionRumenBiologyProtein kinase A
22Publications
11H-index
511Citations
Publications 22
Newest
#1Qiushi XuH-Index: 1
Last. Chuang XuH-Index: 7
view all 8 authors...
ABSTRACT Adipose tissue concentration of reactive oxygen species (ROS) increases in dairy cows with ketosis, suggesting that the tissue experiences oxidative stress. Autophagy, an adaptive response to cellular stress, has been shown to promote survival and plays a critical role in antioxidant responses. Dysregulation of adenosine 5′-monophosphate-activated protein kinase (AMPK) is closely related to antioxidant responses and autophagy of adipocytes in animal models of metabolic disorders, but it...
1 CitationsSource
#1Qiushi XuH-Index: 1
Last. Chuang XuH-Index: 7
view all 8 authors...
ABSTRACT Preadipocyte proliferation and differentiation are critical for normal adipose tissue development, including achieving a mature phenotype, characterized by its ability to accumulate triacylglycerol and release fatty acids. In nonruminants, it is well known that all-trans retinoic acid (ATRA), the most-active form of vitamin A, helps regulate proliferation, differentiation, and apoptosis in several types of cells including adipocytes. The purpose of this study was to evaluate the effect ...
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#1Xudong SunH-Index: 7
#2Yan TangH-Index: 1
Last. Chuang XuH-Index: 7
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ABSTRACT Ketosis is a serious metabolic disorder characterized by systemic and hepatic oxidative stress, inflammation, and apoptosis, as well as reduced milk yield. Because of the paucity of data on mammary responses during ketosis, the aim of this study was to evaluate alterations in oxidative stress, NF-κB signaling, NLRP3 inflammasome, and caspase apoptotic pathways in mammary gland of dairy cows with ketosis. Blood, mammary gland tissue, and milk samples were collected from healthy cows [Con...
1 CitationsSource
#1Qiushi XuH-Index: 1
Last. Chuang XuH-Index: 7
view all 8 authors...
Cardamonin (CD), a naturally occurring chalcone derived from the Alpinia species, has been shown to exert antioxidant and anti-inflammatory activity, but its role in the prevention of acetaminophen (APAP)-induced hepatotoxicity remains elusive. The objective of this study was to determine the protective effects of CD against APAP-induced acute liver injury (ALI) and the underlying mechanisms. Wild-type (WT) or transcription factor nuclear factor erythroid 2-related factor 2 (NFE2L2)-deficient mi...
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#1Chenxu Zhao (JLU: Jilin University)H-Index: 11
#2Gerd Bobe (Linus Pauling Institute)H-Index: 27
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
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Rumen fluid of cows with subacute ruminal acidosis (SARA) has high concentrations of short chain fatty acids (SCFA). However, the mechanism of SCFA accumulation is unknown. The solute-linked carrier 5a8 (SLC5A8) plays a key role in the transportation and absorption of SCFA in the intestinal epithelium. The objective of the current study was to investigate (1) SLC5A8 gene and protein expression in various parts of the bovine gastrointestinal tract, (2) the effect of SCFA on SLC5A8 expression in r...
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#1Xudong SunH-Index: 7
#2Shengbin LuoH-Index: 1
Last. Chuang XuH-Index: 7
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ABSTRACT Exogenous molecules derived from catabolic states (e.g., fatty acids, β-hydroxybutyrate) during periods of stress such as the periparturient period or pathogen challenges [e.g., lipopolysaccharide (LPS)] can trigger an inflammatory response in tissues such as the liver and the mammary gland. Butyrate is one of the major short-chain fatty acids produced in the rumen, and work with non-ruminants has demonstrated that it can alter inflammatory processes. The primary objective of this study...
7 CitationsSource
#1Xinwei Li (JLU: Jilin University)H-Index: 23
#2Guojin Li (JLU: Jilin University)H-Index: 2
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
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ABSTRACT Hyperketonemia is a metabolic disease in dairy cows, associated with negative nutrition balance (NNB) induced by low dry matter intake (DMI) and increased nutrient requirements. Hyperketonemia could induce metabolic stress, which might indirectly affect mammary tissue. Autophagy is a highly conserved physiological process that results in the turnover of intracellular material, and is involved in maintaining cellular homeostasis under the challenge of metabolic stress induced by NNB. The...
5 CitationsSource
#1Xudong SunH-Index: 7
#2Hongdou JiaH-Index: 7
Last. Chuang XuH-Index: 7
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During the transition into lactation, bovine mammary epithelial cells (bMECs) are likely subjected to altered redox balance due to the high metabolic rate associated with the onset of lactation. In non-ruminants, lycopene (LYC), a naturally occurring hydrocarbon carotenoid, has attracted considerable attention as a potential natural agent against oxidative stress. The aim of this study was to investigate whether LYC alleviates oxidative injury in bMECs induced by H2O2 and the underlying molecula...
15 CitationsSource
#1Chenxu Zhao (JLU: Jilin University)H-Index: 11
#2Yazhou Wang (JLU: Jilin University)H-Index: 3
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 8 authors...
: Subacute ruminal acidosis (SARA) is characterized by the depression of ruminal pH and an increase in the concentrations of short-chain fatty acids (SCFAs) and lipopolysaccharide (LPS) in the rumen of cows. The onset of SARA was linked to the accumulation of SCFAs. However, the mechanism of SCFAs transport is unknown. The proton-linked monocarboxylate transporter (MCT1) plays a vital role in the transportation of SCFAs. The goal of this study was to elucidate the distribution of MCT1 along the ...
6 CitationsSource
#1Bingyu Shen (JLU: Jilin University)H-Index: 9
#2Chenxu Zhao (JLU: Jilin University)H-Index: 11
Last. Haihua Feng (JLU: Jilin University)H-Index: 29
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: Aucubin (AU) is the main active ingredient of Aucuba japonica which has showed many positive effects such as anti-inflammation and liver protection. Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. In this research, we explored the effects of AU on the tyloxapol-induced NAFLD in mice and apolipoprotein C-III (apoC-III) induced-3T3L1 cells. Tyloxapol (300 mg/kg) was injected to C57BL/6 mice with aucubin. The differentiated 3T3-L1 cells were treated wi...
26 CitationsSource