Nuno S. Osório
University of Minho
Drug resistanceInternal medicineSingle-nucleotide polymorphismVirologyPhylogenetic treeEpitopeImmunologyLineage (genetic)Transmission (medicine)Mycobacterium tuberculosisPlasmodium falciparumMycobacterium tuberculosis complexTuberculosisSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Human immunodeficiency virus (HIV)Computer scienceNitric oxideGeneticsVirulenceMedicineBiologyImmune systemMicrobiologyPhylogeneticsCell biology
Publications 41
#1Carolina M. Andrade (University Hospital Heidelberg)H-Index: 3
#2Hannah Fleckenstein (University Hospital Heidelberg)H-Index: 2
Last. Shanping Li (NIH: National Institutes of Health)H-Index: 19
view all 37 authors...
The dry season is a major challenge for Plasmodium falciparum parasites in many malaria endemic regions, where water availability limits mosquito vectors to only part of the year. How P. falciparum bridges two transmission seasons months apart, without being cleared by the human host or compromising host survival, is poorly understood. Here we show that low levels of P. falciparum parasites persist in the blood of asymptomatic Malian individuals during the 5- to 6-month dry season, rarely causin...
#1Samuel M. Gonçalves (University of Minho)H-Index: 7
#2Cláudio Duarte-Oliveira (University of Minho)H-Index: 4
Last. Agostinho Carvalho (University of Minho)H-Index: 34
view all 34 authors...
In response to infection, macrophages adapt their metabolism rapidly to enhance glycolysis and fuel specialized antimicrobial effector functions. Here we show that fungal melanin is an essential molecule required for the metabolic rewiring of macrophages during infection with the fungal pathogen Aspergillus fumigatus. Using pharmacological and genetic tools, we reveal a molecular link between calcium sequestration by melanin inside the phagosome and induction of glycolysis required for efficient...
#1Jeremy Nicolas Carvalho Sousa (IBMC: Instituto de Biologia Molecular e Celular)H-Index: 10
#2Baltazar Cá (IBMC: Instituto de Biologia Molecular e Celular)H-Index: 3
Last. Margarida Saraiva (IBMC: Instituto de Biologia Molecular e Celular)H-Index: 29
view all 28 authors...
Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune responses to direct distinct TB severities is unknown. Here we study 681 patients with pulmonary TB and show that M. tuberculosis isolates from cases with mild disease consistently induce robust cytokine responses in macrophages across multiple donors. By contrast, bacteria from patients with severe TB do not do so. Secretion of...
#1Carolina Ferreira (University of Minho)H-Index: 10
#2Inês Mesquita (University of Minho)H-Index: 7
Last. Ricardo Silvestre (University of Minho)H-Index: 28
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Background The disturbance of host metabolic pathways by Leishmania parasites has crucial consequences for the activation status of immune cells and the outcome of infection. Glutamine has been described as an immunomodulatory amino acid, yet its role during Leishmania infection is still unknown. Methods We performed transcriptomics in uninfected and L. donovani-infected macrophages 6 hours post-infection. Glutamine quantification by HPLC was assessed in the supernatant of macrophages throughout...
Last. Silvia PortugalH-Index: 22
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#1Leonor MeiraH-Index: 4
#2Catarina Chaves (RMIT: RMIT University)H-Index: 2
Last. Hélder Novais BastosH-Index: 8
view all 13 authors...
Abstract Setting University-affiliated hospital located in Porto, North Portugal, an area with a low to intermediate incidence of tuberculosis (TB). Objective To identify predictors and outcomes of disseminated TB (dTB). Design A cohort of patients diagnosed with TB between 2007 and 2013 was retrospectively analysed. Patients with dTB criteria were characterized and compared to single organ TB cases. Factors independently associated with dTB were determined by multivariate logistic regression an...
#1Carlos MagalhãesH-Index: 4
#2Iñaki ComasH-Index: 35
Last. Nuno S. OsórioH-Index: 15
view all 4 authors...
Abstract de la comunicacion oral presentada al Scientific Meeting on Mycobacteria. MycoPORTO 2019 Porto (Portugal), 19-20 de septiembre de 2019
#1Pedro Araújo (University of Minho)H-Index: 11
#2Joana S. Martins (University of Minho)H-Index: 1
Last. Nuno S. Osório (University of Minho)H-Index: 15
view all 3 authors...
Human immunodeficiency virus 1 (HIV-1) genome sequencing is routinely done for drug resistance monitoring in hospitals worldwide. Subtyping these extensive datasets of HIV-1 sequences is a critical first step in molecular epidemiology and evolution studies. The clinical relevance of HIV-1 subtypes is increasingly recognized. Several studies suggest subtype-related differences in disease progression, transmission route efficiency, immune evasion, and even therapeutic outcomes. HIV-1 subtyping is ...
#1Joana T. Martins (University of Minho)H-Index: 23
#2Carlos Magalhães (University of Minho)H-Index: 4
Last. Nuno S. Osório (University of Minho)H-Index: 15
view all 4 authors...
: Immune responses mediated by T cells are aimed at specific peptides, designated T cell epitopes, that are recognized when bound to human leukocyte antigen (HLA) molecules. The HLA genes are remarkably polymorphic in the human population allowing a broad and fine-tuned capacity to bind a wide array of peptide sequences. Polymorphisms might generate neoepitopes by impacting the HLA-peptide interaction and potentially alter the level and type of generated T cell responses. Multiple algorithms and...
#1Pedro Araújo (University of Minho)H-Index: 11
#2Alexandre Antonio de Carvalho (University of Minho)H-Index: 4
Last. Nuno S. Osório (University of Minho)H-Index: 15
view all 5 authors...
HIV-1 subtypes associate with differences in transmission and disease progression. Thus, the existence of geographic hotspots of subtype diversity deepens the complexity of HIV-1/AIDS control. The already high subtype diversity in Portugal seems to be increasing due to infections with sub-subtype A1 virus. We performed phylogenetic analysis of 65 A1 sequences newly obtained from 14 Portuguese hospitals and 425 closely related database sequences. 80% of the A1 Portuguese isolates gathered in a ma...
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