Carlo Castellani
Istituto Giannina Gaslini
Internal medicineEndocrinologyGenotypePathologyIntensive care medicineAllelePediatricsNewborn screeningIvacaftorPancreatic diseaseCystic fibrosisImmunoreactive trypsinogenCystic fibrosis transmembrane conductance regulatorDiseaseSweat testPopulationMutationGeneticsMedicineBiologyGastroenterology
Publications 165
#1Elio Castagnola (Istituto Giannina Gaslini)H-Index: 53
#2Giuliana Cangemi (Istituto Giannina Gaslini)H-Index: 17
Last. Francesca Mattioli (UniGe: University of Genoa)H-Index: 20
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Abstract null null Cystic fibrosis affects several organs, predisposing patients to severe bacterial respiratory infections, including those caused by methicillin-resistant Staphylococcus aureus. Cystic fibrosis is also associated with a wide spectrum of pathological changes that can significantly affect the absorption, distribution, metabolism and/or elimination of several drugs, including antibacterial agents. Awareness of the pharmacokinetic derangements in patients with cystic fibrosis is, t...
The aim of this study was the identification of specific proteomic profiles, related to a restored cystic fibrosis transmembrane conductance regulator (CFTR) activity in cystic fibrosis (CF) leukocytes before and after ex vivo treatment with the potentiator VX770. We used leukocytes, isolated from CF patients carrying residual function mutations and eligible for Ivacaftor therapy, and performed CFTR activity together with proteomic analyses through micro-LC–MS. Bioinformatic analyses of the resu...
1 CitationsSource
#1C. Olcese (UniGe: University of Genoa)
#2Rosaria Casciaro (Istituto Giannina Gaslini)H-Index: 9
Last. Carlo Castellani (Istituto Giannina Gaslini)H-Index: 36
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Abstract The effects of the concomitant infection by COVID-19 and Burkholderia cepacia (Bc) in CF are not known. We describe the case of a 34 years woman with CF, colonized by Bc and found SARS-CoV2 positive. In the first hospital week she suffered acute respiratory failure and chest imaging showed interstitial involvement and multiple thickenings. She was treated with antibiotics, dexamethasone, remdesivir and heparin, with gradual improvement and discharge at day 20th. The reciprocal role of S...
#1Riccardo Ciprandi (Istituto Giannina Gaslini)H-Index: 4
#2Maurizio BonatiH-Index: 50
Last. Carlo Castellani (Istituto Giannina Gaslini)H-Index: 36
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Abstract Background - Hundreds of papers have been published on the COVID-19 pandemic, and several of them on psychological themes connected with it, but very little is so far known on how adult patients with Cystic Fibrosis (pwCFs) are coping with this dramatic event. Methods – An online questionnaire was developed according to the Italian validated COVID-19 Peritraumatic Distress Index (CPDI) and addressed to the general population (GP). A similar questionnaire, augmented with CF specific ques...
3 CitationsSource
#1Anne Munck (Paris V: Paris Descartes University)H-Index: 33
#1Anne Munck (Paris V: Paris Descartes University)
Last. Jürg Barben (Boston Children's Hospital)H-Index: 11
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2 CitationsSource
#1Federico Cresta (Istituto Giannina Gaslini)H-Index: 5
#2Luca Arcuri (Istituto Giannina Gaslini)H-Index: 1
Last. Giuliana Cangemi (Istituto Giannina Gaslini)H-Index: 17
view all 9 authors...
#1Jürg Barben (Boston Children's Hospital)H-Index: 11
#2Carlo Castellani (Istituto Giannina Gaslini)H-Index: 36
Last. Kevin W Southern (University of Liverpool)H-Index: 30
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Over the past two decades there has been considerable progress with the evaluation and management of infants with an inconclusive diagnosis following Newborn Screening (NBS) for cystic Fibrosis (CF). In addition, we have an increasing amount of evidence on which to base guidance on the management of these infants and, importantly, we have a consistent designation being used across the globe of CRMS/CFSPID. There is still work to be undertaken and research questions to answer, but these infants n...
7 CitationsSource
#1Andrea Gramegna (University of Milan)H-Index: 11
#2Martina Contarini (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 7
Last. Carlo Castellani (Istituto Giannina Gaslini)H-Index: 36
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Over the last years CFTR (cystic fibrosis transmembrane conductance regulator) modulators have shown the ability to improve relevant clinical outcomes in patients with cystic fibrosis (CF). This review aims at a systematic research of the current evidence on efficacy and tolerability of CFTR modulators for different genetic subsets of patients with CF. Two investigators independently performed the search on PubMed and included phase 2 and 3 clinical trials published in the study period 1 January...
10 CitationsSource
Today, newborn screening (NBS) is considered an essential component in the standards of care for cystic fibrosis (CF) [...]
#1Andrea Amerio (UniGe: University of Genoa)H-Index: 9
#2Francesca Sibilla (UniGe: University of Genoa)H-Index: 1
Last. Federico Cresta (Istituto Giannina Gaslini)H-Index: 5
view all 14 authors...
4 CitationsSource