Miqin Zhang
University of Washington
Surface modificationCancerBiophysicsBiomedical engineeringNanoparticleNanotechnologyChemistryMaterials scienceIn vivoEthylene glycolIron oxide nanoparticlesChlorotoxinChitosanDrug deliveryTissue engineeringCancer researchPEG ratioScaffoldNanofiberCancer cell
223Publications
82H-index
23.6kCitations
Publications 209
Newest
#1Tom Thomas (Harvard University)H-Index: 2
#2Ken Miyaguchi (Cedars-Sinai Medical Center)
Last. John Yu (Cedars-Sinai Medical Center)H-Index: 74
view all 16 authors...
Asparagine synthetase (ASNS) is a gene on the long arm of chromosome 7 that is copy number amplified in the majority of glioblastomas. ASNS copy number amplification is associated with a significantly decreased survival. Using patient-derived glioma stem cells (GSCs), we showed significant metabolic alterations occur in gliomas when perturbing the expression of asparagine synthetase, which is not merely restricted to amino acid homeostasis. ASNS-high GSCs maintained a slower basal metabolic prof...
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#1Kui Wang (UW: University of Washington)H-Index: 21
#2Forrest M. Kievit (NU: University of Nebraska–Lincoln)H-Index: 35
Last. Miqin Zhang (UW: University of Washington)H-Index: 82
view all 8 authors...
Temozolomide (TMZ) is the standard of care chemotherapy drug for treating glioblastomas (GBMs), the most aggressive cancer that affects people of all ages. However, its therapeutic efficacy is limited by the drug resistance mediated by a DNA repair protein, O6-methylguanine-DNA methyltransferase (MGMT), which eliminates the TMZ-induced DNA lesions. Here we report the development of an iron oxide nanoparticle (NP) system for targeted delivery of siRNAs to suppress the TMZ-resistance gene (MGMT). ...
1 CitationsSource
#1Guanyou Lin (UW: University of Washington)H-Index: 5
#2Qingxin Mu (UW: University of Washington)H-Index: 24
Last. Miqin Zhang (UW: University of Washington)H-Index: 82
view all 6 authors...
The ability to visualize and quantify apoptosis in vivo is critical to monitoring disease response to treatment and providing prognosis information. However, the application of current apoptosis labeling probes faces significant challenges including nonspecific tissue labeling, short monitoring windows, and low signal to noise ratios. Here we report a highly specific apoptosis labeling nanoparticle (NP) probe with pisum sativum agglutinin (PSA) as tumor targeting ligand for prolonged in vivo apo...
1 CitationsSource
#1Guanyou Lin (UW: University of Washington)H-Index: 5
#2Richard A. Revia (UW: University of Washington)H-Index: 12
Last. Miqin Zhang (UW: University of Washington)H-Index: 82
view all 3 authors...
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#1Zachary R. Stephen (UW: University of Washington)H-Index: 17
#2Miqin Zhang (UW: University of Washington)H-Index: 82
Immunotherapy has demonstrated great clinical success in certain cancers, driven primarily by immune checkpoint blockade and adoptive cell therapies. Immunotherapy can elicit strong, durable responses in some patients, but others do not respond, and to date immunotherapy has demonstrated success in only a limited number of cancers. To address this limitation, combinatorial approaches with chemo- and radiotherapy have been applied in the clinic. Extensive preclinical evidence suggests that hypert...
2 CitationsSource
#1Matthew JamesH-Index: 1
#2Richard A. ReviaH-Index: 12
Last. Miqin ZhangH-Index: 82
view all 4 authors...
Research efforts into the production and application of iron oxide nanoparticles (IONPs) in recent decades have shown IONPs to be promising for a range of biomedical applications. Many synthesis techniques have been developed to produce high-quality IONPs that are safe for in vivo environments while also being able to perform useful biological functions. Among them, coprecipitation is the most commonly used method but has several limitations such as polydisperse IONPs, long synthesis times, and ...
4 CitationsSource
#1Mike Jeon (UW: University of Washington)H-Index: 9
#2Guanyou Lin (UW: University of Washington)H-Index: 5
Last. Miqin Zhang (UW: University of Washington)H-Index: 82
view all 9 authors...
Molecular imaging of the dopamine transporter (DAT) with Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) has been widely used in studies of neurological and psychiatric disorders. Nevertheless, there is a great interest in expanding molecular imaging to include magnetic resonance technology, because of the superior spatial resolution this technology may provide. Here we present a magnetic nanoparticle (NP) that specifically targets dopaminergic neurons an...
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#1Mike Jeon (UW: University of Washington)H-Index: 9
#2Mackenzie V. Halbert (UW: University of Washington)H-Index: 1
Last. Miqin Zhang (UW: University of Washington)H-Index: 82
view all 4 authors...
Gadolinium-based chelates are a mainstay of contrast agents for magnetic resonance imaging (MRI) in the clinic. However, their toxicity elicits severe side effects and the Food and Drug Administration has issued many warnings about their potential retention in patients' bodies, which causes safety concerns. Iron oxide nanoparticles (IONPs) are a potentially attractive alternative, because of their nontoxic and biodegradable nature. Studies in developing IONPs as T1 contrast agents have generated...
13 CitationsSource
#1Wai-Yim Ching (UMKC: University of Missouri–Kansas City)H-Index: 75
#2Saro San (UMKC: University of Missouri–Kansas City)H-Index: 3
Last. Peter K. Liaw (UT: University of Tennessee)H-Index: 7
view all 6 authors...
High-entropy alloys (HEAs) have attracted great attention due to their many unique properties and potential applications. The nature of interatomic interactions in this unique class of complex multicomponent alloys is not fully developed or understood. We report a theoretical modeling technique to enable in-depth analysis of their electronic structures and interatomic bonding, and predict HEA properties based on the use of the quantum mechanical metrics, the total bond order density (TBOD) and t...
12 CitationsSource
#1Qingxin Mu (UW: University of Washington)H-Index: 24
#2Guanyou Lin (UW: University of Washington)H-Index: 5
Last. Miqin Zhang (UW: University of Washington)H-Index: 82
view all 8 authors...
Abstract Systemic delivery of hydrophobic anti-cancer drugs with nanocarriers, particularly for drug-resistant and metastatic cancer, remain a challenge because of the difficulty to achieve high drug loading, while maintaining a small hydrodynamic size and colloid stability in blood to ensure delivery of an efficacious amount of drug to tumor cells. Here we introduce a new approach to address this challenge. In this approach, nanofibers of larger size with good drug loading capacity are first co...
1 CitationsSource