Jong-Dai Kim
Kangwon National University
EndocrinologyHippocampal formationTumor necrosis factor alphaChemistryApoptosisNeuroprotectionOxidative stressGliosisAntioxidantMicrogliaGerbilNeuNHippocampusAnesthesiaIschemiaBiochemistryMedicineBiologyCancer cellPharmacology
Publications 39
#1Ji Hyeon Ahn (Hallym University)H-Index: 15
#2Young-Eun Park (Kangwon National University)H-Index: 15
Last. Moo-Ho Won (Kangwon National University)H-Index: 44
view all 11 authors...
#1Young Her (Kangwon National University)H-Index: 4
#2Bich-Na Shin (Hallym University)H-Index: 7
Last. Ji Hyeon AhnH-Index: 16
view all 11 authors...
In recent years, the use of botanical agents to prevent skin damage from solar ultraviolet (UV) irradiation has received considerable attention. Oenanthe javanica is known to exert anti-inflammatory and antioxidant activities. This study investigated photoprotective properties of an Oenanthe javanica extract (OJE) against UVB-induced skin damage in ICR mice. The extent of skin damage was evaluated in three groups: control mice with no UVB, UVB-exposed mice treated with vehicle (saline), and UVB-...
5 CitationsSource
#1Ji Hyeon Ahn (Hallym University)H-Index: 16
#2Myoung Cheol Shin (Kangwon National University)H-Index: 8
Last. Joon Ha Park (Hallym University)H-Index: 21
view all 14 authors...
Fucoidan, a natural sulfated polysaccharide, displays various biological activities including antioxidant properties. We examined the neuroprotective effect of fucoidan against transient global cerebral ischemia (tGCI) in high-fat diet (HFD)-induced obese gerbils and its related mechanisms. Gerbils received HFD for 12 weeks and fucoidan (50 mg/kg) daily for the last 5 days during HFD exposure, and they were subjected to 5-min tGCI. Pyramidal cell death was observed only in the CA 1 area (CA1) of...
14 CitationsSource
#1Hyun-Jung Kim (Kangwon National University)H-Index: 12
#1Hyun-Jung Kim (Kangwon National University)H-Index: 13
Last. Joon Ha Park (Hallym University)H-Index: 21
view all 13 authors...
Abstract Fucoidan is a sulfated polysaccharide derived from brown algae and possesses various beneficial activities, including antioxidant property. Previous studies have shown that fucoidan displays protective effect against ischemia-reperfusion injury in some organs. However, few studies have been reported regarding the protective effect of fucoidan against transient cerebral ischemic insults and its related mechanisms. Therefore, in this study, we examined the neuroprotective effect of fucoid...
24 CitationsSource
#1Hyun-Jin Tae (CBNU: Chonbuk National University)H-Index: 11
#2Il Jun Kang (Hallym University)H-Index: 14
Last. Young Joo LeeH-Index: 17
view all 16 authors...
Low survival rate occurs in patients who initially experience a spontaneous return of circulation after cardiac arrest (CA). In this study, we induced asphyxial CA in adult male Sprague-Daley rats, maintained their body temperature at 37 ± 0.5°C, and then observed the survival rate during the post-resuscitation phase. We examined neuronal damage in the hippocampus using cresyl violet (CV) and Fluore-Jade B (F-J B) staining, and pro-inflammatory response using ionized calcium-binding adapter mole...
5 CitationsSource
#1Joon Ha Park (Hallym University)H-Index: 21
#2Tae-Kyeong Lee (Kangwon National University)H-Index: 11
Last. Moo-Ho Won (Kangwon National University)H-Index: 44
view all 15 authors...
: The genus Populus (poplar) belonging to the Salicaceae family has been used in traditional medicine, and its several species show various pharmacological properties including antioxidant and anti-inflammatory effects. No study regarding protective effects of Populus species against cerebral ischemia has been reported. Therefore, in the present study, we examined neuroprotective effects of ethanol extract from Populus tomentiglandulosa (Korea poplar) in the hippocampal cornu ammonis (CA1) area ...
9 CitationsSource
#1Joon Ha Park (Hallym University)H-Index: 21
#2Chan Woo Park (Kangwon National University)H-Index: 8
Last. Il Jun Kang (Hallym University)H-Index: 14
view all 19 authors...
Abstract Hydroquinone (HQ), a major metabolite of benzene, exists in many plant-derived food and products. Although many studies have addressed biological properties of HQ including the regulation of immune responses and antioxidant activity, neuroprotective effects of HQ following ischemic insults have not yet been considered. Therefore, in this study, we examined neuroprotective effects of HQ against ischemic damage in the gerbil hippocampal cornu ammonis 1 (CA1) region following 5 min of tran...
13 CitationsSource
#1Joon Ha Park (Kangwon National University)H-Index: 21
#2Hyun Young Choi (Hallym University)H-Index: 6
Last. Jong-Dai Kim (Kangwon National University)H-Index: 13
view all 17 authors...
Myelin plays an important role in learning and memory, and degradation of myelin is a key feature in the pathogenesis of neurological disorders involving cognitive dysfunction. Myelin basic protein (MBP) is one of the most abundant structural proteins in myelin and is essential for myelin formation and compaction. In this study, we first examined changes in the distribution of MBP-immunoreactive myelinated fibers and MBP levels according to hippocampal subregion in mice following chronic systemi...
11 CitationsSource
#1Bai Hui Chen (Hallym University)H-Index: 11
#2Joon Ha Park (Kangwon National University)H-Index: 21
Last. Yun Lyul Lee (Hallym University)H-Index: 13
view all 13 authors...
Tanshinone I (TsI), a lipophilic diterpene extracted from Danshan (Radix Salvia miltiorrhizae), exerts neuroprotection in cerebrovascular diseases including transient ischemic attack. In this study, we examined effects of TsI on cell proliferation and neuronal differentiation in the subgranular zone (SGZ) of the mouse dentate gyrus (DG) using Ki-67, BrdU and doublecortin (DCX) immunohistochemistry. Mice were treated with 1 and 2 mg/kg TsI for 28 days. In the 1 mg/kg TsI-treated-group, distributi...
13 CitationsSource
#1Ki-Yeon Yoo (Gangneung–Wonju National University)H-Index: 31
#2In Hye Kim (Kangwon National University)H-Index: 17
Last. Il Jun Kang (Hallym University)H-Index: 14
view all 12 authors...
In this study, we tried to verify the neuroprotective effect of Chrysanthemum indicum Linne (CIL) extract, which has been used as a botanical drug in East Asia, against ischemic damage and to explore the underlying mechanism involving the anti-inflammatory approach. A gerbil was given CIL extract for 7 consecutive days followed by bilateral carotid artery occlusion to make a cerebral ischemia/reperfusion model. Then, we found that CIL extracts protected pyramidal neurons in the hippocampal CA1 r...
11 CitationsSource
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