Dengli Wang
Okayama University
Therapeutic effectGlycoproteinInternal medicineEndocrinologyPathologyGlycationCellular differentiationCellProinflammatory cytokineReceptorChemistryHistidine-rich glycoproteinInflammationIntracerebral hemorrhageSepsisPregnancyMicrogliaVasoconstrictionHMGB1PathogenesisBrain damageExtracellularHigh-mobility groupAnesthesiaCancer researchBarrier functionMonoclonal antibodyBiochemistryMedicineCell cultureBiologyMicrobiologyCell biologyPharmacology
31Publications
6H-index
145Citations
Publications 32
Newest
#1Kaori Masai (Okayama University)H-Index: 1
#2Keita Kuroda (Okayama University)
Last. Masahiro Nishibori (Okayama University)H-Index: 51
view all 11 authors...
High mobility group box-1 (HMGB1) is a ubiquitous non-histone nuclear protein that plays a key role as a transcriptional activator, with its extracellular release provoking inflammation. Inflammatory responses are essential in methamphetamine (METH)-induced acute dopaminergic neurotoxicity. In the present study, we examined the effects of neutralizing anti-HMGB1 monoclonal antibody (mAb) on METH-induced dopaminergic neurotoxicity in mice. BALB/c mice received a single intravenous administration ...
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#1Yicheng Zhu (Kyushu University)H-Index: 2
#2Naohiro Uezono (Kyushu University)H-Index: 5
Last. Kinichi Nakashima (Kyushu University)H-Index: 74
view all 8 authors...
Spinal cord injury (SCI) causes motor and sensory deficits and is currently considered an incurable disease. We have previously reported that administration of anti-High Mobility Group Box-1 monoclonal antibody (anti-HMGB1 mAb) preserved lesion area and improved locomotion recovery in mouse model of SCI. In order to further enhance the recovery, we here examined combinatorial treatment of anti-HMGB1 mAb and epothilone B (Epo B), which has been reported to promote axon regeneration. This combinat...
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#1Takahiro KochiH-Index: 1
#2Yoki NakamuraH-Index: 14
Last. Norimitsu MoriokaH-Index: 25
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Persistent pain following orofacial surgery is not uncommon. High mobility group box 1 (HMGB1), an alarmin, is released by peripheral immune cells following nerve injury and could be related to pain associated with trigeminal nerve injury. Distal infraorbital nerve chronic constriction injury (dIoN-CCI) evokes pain-related behaviors including increased facial grooming and hyper-responsiveness to acetone (cutaneous cooling) after dIoN-CCI surgery in mice. In addition, dIoN-CCI mice developed cond...
1 CitationsSource
#1Yohei TakahashiH-Index: 2
#2Hidenori WakeH-Index: 17
Last. Masahiro NishiboriH-Index: 51
view all 7 authors...
Histidine-rich glycoprotein (HRG) is a multifunctional plasma protein and maintains the homeostasis of blood cells and vascular endothelial cells. In the current study, we demonstrate that HRG and recombinant HRG concentration dependently induced the phagocytic activity of isolated human neutrophils against fluorescence-labeled Escherichia coli and Staphylococcus aureus through the stimulation of CLEC1A receptors, maintaining their spherical round shape. The phagocytosis-inducing effects of HRG ...
1 CitationsSource
#1Yoki Nakamura (Hiroshima University)H-Index: 14
#2Ayako Fukuta (Hiroshima University)H-Index: 1
Last. Norimitsu Morioka (Hiroshima University)H-Index: 25
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Abstract High mobility box 1 (HMGB1), a damage-associated molecular pattern, has crucial roles in induction of neuropathic pain. Upregulation of HMGB1 around the injured sciatic nerve contributes to mechanical hypersensitivity following partial sciatic nerve ligation (PSNL) of mice. However, central mechanisms mediating perineural HMGB1-induced nociceptive hypersensitivity, especially within the spinal dorsal horn, have not been determined. The current study shows that perineural treatment of na...
1 CitationsSource
#1Kiyoshi Teshigawara (Okayama University)H-Index: 18
#2Keyue Liu (Okayama University)H-Index: 25
Last. Masahiro Nishibori (Okayama University)H-Index: 51
view all 7 authors...
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#1Muraoka Genya (Okayama University)
#2Keyue Liu (Okayama University)H-Index: 25
Last. Masahiro Nishibori (Okayama University)H-Index: 51
view all 8 authors...
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#1Yukinori Yoshii (Okayama University)H-Index: 3
#2Hidenori Wake (Okayama University)H-Index: 17
Last. Masahiro Nishibori (Okayama University)H-Index: 51
view all 6 authors...
Background: Histidine-rich glycoprotein (HRG) treatment ameliorated the survival rate of septic mice by suppressing excess immunothrombus formation. Although such findings suggested that HRG may be one of the most useful drugs for sepsis, obtaining a stable experimental system to standardize the HRG drug product is difficult to achieve using neutrophils isolated from volunteers. This is due to the short survival time and individual differences of human neutrophils. In the present study, we deter...
1 CitationsSource
#1Masahiro NishiboriH-Index: 51
#2Dengli WangH-Index: 6
Last. Hidenori WakeH-Index: 17
view all 4 authors...
Increasing evidence suggests that inflammatory responses are involved in the progression of brain injuries induced by a diverse range of insults, including ischemia, hemorrhage, trauma, epilepsy, and degenerative diseases. During the processes of inflammation, disruption of the blood–brain barrier (BBB) may play a critical role in the enhancement of inflammatory responses and may initiate brain damage because the BBB constitutes an interface between the brain parenchyma and the bloodstream conta...
7 CitationsSource
#1Hidenori Wake (Okayama University)H-Index: 17
#2Yohei Takahashi (Okayama University)H-Index: 2
Last. Masahiro Nishibori (Okayama University)H-Index: 51
view all 8 authors...
Sepsis is caused by infections associated with life-threatening multiple organ failure (MOF). Septic MOF appears to be closely related to circulatory failure due to immunothrombosis. This process i...
2 CitationsSource