Marc A. Soares
New York University
Gene silencingSurgeryPathologyCellular differentiationMesenchymal stem cellProgenitor cellImmunologyEx vivoPumaWound healingStem cellVascularized Composite AllotransplantationTransplantationReactive oxygen speciesCancer researchMedicinecGMP-specific phosphodiesterase type 5BiologyCell biologyPharmacology
43Publications
13H-index
582Citations
Publications 41
Newest
#1Piul S. Rabbani (NYU: New York University)H-Index: 12
#2Marc A. Soares (NYU: New York University)H-Index: 13
Last. Daniel J. Ceradini (NYU: New York University)H-Index: 23
view all 7 authors...
The molecular and cellular level reaches of the metabolic dysregulations that characterize diabetes are yet to be fully discovered. As mechanisms underlying management of reactive oxygen species (ROS) gain interest as crucial factors in cell integrity, questions arise about the role of redox cues in regulation and maintenance of bone marrow-derived multipotent stromal cells (BMSCs) that contribute to wound healing, particularly in diabetes. Through comparison of BMSCs from wild type and diabetic...
22 CitationsSource
#1Maria J. Kowzun (NYU: New York University)H-Index: 2
#2William J. Rifkin (NYU: New York University)H-Index: 8
Last. Daniel J. Ceradini (NYU: New York University)H-Index: 23
view all 11 authors...
: Radiation therapy is an effective treatment strategy for many types of cancer but is limited by its side effects on normal tissues, particularly the skin, where persistent and progressive fibrotic changes occur and can impair wound healing. In this study, we attempted to mitigate the effects of irradiation on skin using a novel transcutaneous topical delivery system to locally inhibit p53 up-regulated modulator of apoptosis (PUMA) gene expression with small interfering RNA (siRNA). In an isola...
2 CitationsSource
: Current pharmacologic regimens in transplantation prevent allograft rejection through systemic recipient immunosuppression but are associated with severe morbidity and mortality. The ultimate goal of transplantation is the prevention of allograft rejection while maintaining recipient immunocompetence. We hypothesized that allografts could be engineered ex vivo (after allotransplant procurement but before transplantation) by using mesenchymal stem cell-based therapy to generate localized immuno...
5 CitationsSource
#1Jessica B. Chang (NYU: New York University)H-Index: 7
#2William J. Rifkin (NYU: New York University)H-Index: 8
Last. Daniel J. Ceradini (NYU: New York University)H-Index: 23
view all 10 authors...
Background: Widespread application of vascularized composite allotransplantation (VCA) is currently limited by the required lifelong systemic immunosuppression and its associated morbidity and mortality. This study evaluated the efficacy of ex vivo (after procurement but before transplantation) engineering of allografts using small interfering RNA to knockdown major histocompatibility complex I (MHC-I) and prolong rejection-free survival. Methods: Endothelial cells (ECs) were transfected with sm...
2 CitationsSource
#1Patrick L. Reavey (NYU: New York University)H-Index: 13
#2John T. Stranix (U of C: University of Chicago)H-Index: 9
Last. Vishal D. ThanikH-Index: 15
view all 5 authors...
Background:Significantly fewer replantations have been performed at the authors’ institution in recent years, with similar trends observed across the United States. A study of three national databases was performed to evaluate this trend, its possible cause, and national health care implications.Met
10 CitationsSource
#1Rohini L. Kadle (NYU: New York University)H-Index: 4
#2Salma A. Abdou (NYU: New York University)H-Index: 6
Last. Daniel J. Ceradini (NYU: New York University)H-Index: 23
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Mesenchymal stem cells (MSCs) are known to both have powerful immunosuppressive properties and promote allograft tolerance. Determining the environmental oxygen tension and inflammatory conditions under which MSCs are optimally primed for this immunosuppressive function is essential to their utilization in promoting graft tolerance. Of particular interest is the mechanisms governing the interaction between MSCs and regulatory T cells (Tregs), which is relatively unknown. We performed our experim...
30 CitationsSource
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#1Marc A. Soares (NYU: New York University)H-Index: 13
#2Oriana Cohen (NYU: New York University)H-Index: 6
Last. Daniel J. Ceradini (NYU: New York University)H-Index: 23
view all 11 authors...
Chronic hyperglycemia impairs intracellular redox homeostasis and contributes to impaired diabetic tissue regeneration. The Keap1/Nrf2 pathway is a critical regulator of the endogenous antioxidant response system, and its dysfunction has been implicated in numerous pathologies. Here we characterize the effect of chronic hyperglycemia on Nrf2 signaling within a diabetic cutaneous regeneration model. We characterized the effects of chronic hyperglycemia on the Keap1/Nrf2 pathway within models of d...
34 CitationsSource
1 CitationsSource
#1Marc A. SoaresH-Index: 13
#2Nakul RaoH-Index: 2
Last. Daniel J. CeradiniH-Index: 23
view all 7 authors...
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