Ronit Katz
University of Washington
Internal medicineEndocrinologyRenal functionCardiologyProspective cohort studyCohort studyHazard ratioAlbuminuriaHeart failureKidney diseaseCystatin CCreatininePopulationConfidence intervalProportional hazards modelRisk factorDiabetes mellitusMedicineCohortGastroenterology
Publications 311
#1Christine Bakhoum (Yale University)
#2Ronit Katz (UW: University of Washington)H-Index: 79
Last. Pranav S. Garimella (UCSD: University of California, San Diego)H-Index: 20
view all 7 authors...
Background and objectives: The physiological nocturnal blood pressure decline is often blunted in patients with chronic kidney disease (CKD); however, the consequences of blood pressure non-dipping in children are largely unknown. Our objective was to determine risk factors for non-dipping and to investigate if non-dipping is associated with higher left ventricular mass index (LVMI) in children with CKD. Design, setting, participants, and measurements: We conducted a cross-sectional analysis of ...
#1Orlando M. Gutiérrez (UAB: University of Alabama at Birmingham)H-Index: 53
#2Michael G. Shlipak (UCSF: University of California, San Francisco)H-Index: 128
Last. Joachim H. Ix (UCSD: University of California, San Diego)H-Index: 83
view all 15 authors...
RATIONALE & OBJECTIVE Most circulating biomarkers of chronic kidney disease (CKD) progression focus on factors reflecting glomerular filtration. Few biomarkers capture non-glomerular pathways of kidney injury or damage, which may be particularly informative in populations at high risk for CKD progression such as individuals with diabetes. STUDY DESIGN Cohort study. SETTING & PARTICIPANTS 594 participants (mean age 70, 53% women) of the Reason for Geographic and Racial Differences in Stroke study...
#1Pranav S. GarimellaH-Index: 20
#2Ronit KatzH-Index: 79
Last. Joachim H. IxH-Index: 83
view all 12 authors...
Rationale and objectives null Tubular secretion plays an important role in the efficient elimination of endogenous solutes and medications, and lower secretory clearance is associated with risk of kidney function decline. We evaluated whether histopathologic quantification of interstitial fibrosis and tubular atrophy (IFTA) was associated with lower tubular secretory clearance in persons undergoing kidney biopsy. null Study design null Cross sectional. null Settings and participants null The Bos...
#1David A. Drew (Tufts Medical Center)H-Index: 58
#2Ronit Katz (UW: University of Washington)H-Index: 79
Last. Orlando M. Gutiérrez (UAB: University of Alabama at Birmingham)H-Index: 53
view all 12 authors...
Background and objectives null Hypertension is associated with significant morbidity and mortality despite effective antihypertensive therapies. Soluble klotho is a circulating protein that in preclinical studies is protective against the development of hypertension. There are limited studies of klotho and blood pressure in humans. null Design, setting, participants, & measurements null Within the Health, Aging, and Body Composition Study, a cohort of well-functioning older adults, soluble kloth...
#1Shilpa Sharma (UCLA: University of California, Los Angeles)H-Index: 5
#2Ronit KatzH-Index: 79
view all 12 authors...
Background: Relative abundance of fibroblast growth factor-23 (FGF23) measured by the C-terminal (cFGF23, which measures both intact FGF23 & c-terminal fragments) vs intact (iFGF23, measures only intact hormone) assays varies by kidney function in humans. Differential kidney clearance may explain this. Methods: We measured cFGF23 and iFGF23 in the aorta and bilateral renal veins of 162 patients with essential hypertension undergoing renal angiography. Using multivariable linear regression models...
#1Simon B. Ascher (UC Davis: University of California, Davis)H-Index: 5
#2Rebecca Scherzer (UCSF: University of California, San Francisco)H-Index: 39
Last. Ronit Katz (UW: University of Washington)H-Index: 79
view all 16 authors...
Background null Measures of kidney tubule health are risk markers for acute kidney injury (AKI) in persons with chronic kidney disease (CKD) during hypertension treatment, but their associations with other adverse events (AEs) are unknown. null Methods null Among 2,377 Systolic Blood Pressure Intervention Trial (SPRINT) participants with CKD, we measured at baseline eight urine biomarkers of kidney tubule health and two serum biomarkers of mineral metabolism pathways that act on the kidney tubul...
#4Jan M. Hughes-Austin (Veterans Health Administration)H-Index: 12
#5Lindsay M. Miller (Veterans Health Administration)H-Index: 2
Last. Joachim H. Ix (Veterans Health Administration)H-Index: 83
view all 10 authors...
Recent studies have suggested that 25-hydroxyvitamin D (25(OH)D) may be a poor biomarker of bone health, in part because measured levels incorporate both protein-bound and free vitamin D. The ratio of its catabolic product (24,25-dihydroxyvitamin D [24,25(OH)2 D]) to 25(OH)D (the vitamin D metabolite ratio [VMR]) may provide more information on sufficient vitamin D stores and is not influenced by vitamin D-binding protein concentrations. We evaluated whether the VMR or 25(OH)D are more strongly ...
#1Hayley J. MacKinnon (UW: University of Washington)H-Index: 1
#2Teodora Kolarova (UW: University of Washington)H-Index: 1
Last. Shani Delaney (UW: University of Washington)H-Index: 13
view all 0 authors...
BACKGROUND Maternal biologic factors can affect fetal fraction in cell-free DNA-based prenatal screening assays, thereby limiting effectiveness. Higher rates of indeterminate results from low fetal fraction have been described in cases of autoimmune disease in pregnancy. Existing studies are confounded by the concomitant maternal use of anticoagulants, which may independently influence test characteristics. OBJECTIVE(S) To evaluate differences in fetal fraction, indeterminate results, and total ...
#7Adolfo Correa (UMMC: University of Mississippi Medical Center)H-Index: 77
ABSTRACT null Rationale and Objective null Apolipoprotein L1 (APOL1) high-risk variants are associated with an increased risk of chronic kidney disease (CKD) among African Americans. Less is known regarding the risk of development of CKD and kidney failure (ESKD) among African Americans with only one APOL1 risk variant or whether the risk is modified by sickle cell trait. null Study Design null The Jackson Heart Study is a community-based, longitudinal cohort study. null Setting and Participants...
#1Rakesh Malhotra (UCSD: University of California, San Diego)H-Index: 18
#2Ronit Katz (UW: University of Washington)H-Index: 79
Last. Joachim H. Ix (UCSD: University of California, San Diego)H-Index: 83
view all 19 authors...
Rationale and Objective Although low estimated glomerular filtration rate (eGFR) is associated with cardiovascular disease (CVD) events and mortality, the clinical significance of variability in eGFR over time is uncertain. This study aimed to evaluate the associations between variability in eGFR and the risk of CVD events and all-cause mortality. Study Design Longitudinal analysis of clinical trial participants. Settings and Participants 7,520 Systolic Blood Pressure Intervention Trial (SPRINT)...
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