Hugh Ip
St Thomas' Hospital
CancerInternal medicineSurgeryPediatricsMultidisciplinary approachReferralMalignant pleural effusionLung cancerSittingPleural diseaseTissue plasminogen activatorConnective tissue diseasePleurodesisEmpyemaSepsisThoracoscopyPatient pathwayMedical schoolWaiting timeReferral to treatmentAnesthesiaMedical educationFamily medicineGeneral surgeryMedicine
26Publications
4H-index
84Citations
Publications 26
Newest
#1Deirdre B. Fitzgerald (SCGH: Sir Charles Gairdner Hospital)H-Index: 5
#2Sanjeevan Muruganandan (SCGH: Sir Charles Gairdner Hospital)H-Index: 2
Last. Y. C. Gary Lee (SCGH: Sir Charles Gairdner Hospital)H-Index: 46
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BACKGROUND Indwelling pleural catheters (IPC) are increasingly used for management of recurrent (especially malignant) effusions. Pleural infection associated with IPC use remains a concern. Intrapleural therapy with tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) significantly reduces surgical referrals in non-IPC pleural infection, but data on its use in IPC-related pleural infection are scarce. OBJECTIVE To assess the safety and efficacy of intrapleural tPA and DNase in IPC-r...
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#1Hugh Ip (Guy's and St Thomas' NHS Foundation Trust)H-Index: 4
#2Parthipan Sivakumar (Guy's and St Thomas' NHS Foundation Trust)H-Index: 6
Last. Liju Ahmed (Guy's and St Thomas' NHS Foundation Trust)H-Index: 7
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CTD-related pleural effusions are rare and challenging to diagnose. Our lung inflammation service (with expertise in rheumatology, interstitial lung disease and respiratory failure) works closely with the pleural team. This study aims to review the multidisciplinary approach to CTD-related pleural effusions at a tertiary centre. All patients with CTD-related pleural effusions at St Thomas’ Hospital, London were included. Retrospective data were collected from Dec 2013 to 2016. The lung inflammat...
4 CitationsSource
#1Natalia PopowiczH-Index: 8
#2Hugh Ip (Guy's and St Thomas' NHS Foundation Trust)H-Index: 4
Last. Yun Chor Gary LeeH-Index: 7
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#1Hugh Ip (Guy's and St Thomas' NHS Foundation Trust)H-Index: 4
#2S Ahmed (Guy's and St Thomas' NHS Foundation Trust)
Last. Liju Ahmed (Guy's and St Thomas' NHS Foundation Trust)H-Index: 7
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Introduction and objectives During thoracoscopy for suspected malignant pleural effusions, non-expandable lung (NEL) is managed with indwelling pleural catheters (IPCs) at our centre. To choose the appropriate drain, medical thoracoscopists need to predict NEL. In a 2016 UK survey,1 NEL was correctly predicted in only 12.5% of cases (on reviewing thoracoscopy video clips). Are thoracoscopists better at choosing the appropriate management in clinical practice? Methods All medical thoracoscopies a...
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#1Hugh Ip (Guy's and St Thomas' NHS Foundation Trust)H-Index: 4
#2S Ahmed (Guy's and St Thomas' NHS Foundation Trust)
Last. Liju Ahmed (Guy's and St Thomas' NHS Foundation Trust)H-Index: 7
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Introduction and objectives Medical thoracoscopy, the gold standard diagnostic test in pleural disease, is only performed at experienced pleural units. Training requirements for competence are not defined in the UK,1 where there is no formalised programme. Our tertiary pleural unit provides training opportunities for ward based registrars who have general medical and specialist clinic commitments, as well as dedicated pleural clinical research fellows. Methods All medical thoracoscopies at St Th...
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#1Hugh Ip (Guy's and St Thomas' NHS Foundation Trust)H-Index: 4
#2Alex West (Guy's and St Thomas' NHS Foundation Trust)H-Index: 9
Last. Liju Ahmed (Guy's and St Thomas' NHS Foundation Trust)H-Index: 7
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Introduction: The efficacy of intrapleural alteplase 10mg and dornase alfa (DNase) 5mg in pleural infection was established in the MIST-2 trial. Popowicz N et al suggested that alteplase could be reduced to 5mg (1). Aims and Objectives: To assess the efficacy and safety of 2.5mg of alteplase with 5mg DNase. Methods: All patients with pleural infection at St Thomas’ Hospital, London treated with intrapleural fibrinolysis were included. Retrospective data was collected from Jan 2017 to Jan 2018. T...
2 CitationsSource
#1Hugh IpH-Index: 4
Last. Liju AhmedH-Index: 7
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#1Hugh IpH-Index: 4
Last. Liju AhmedH-Index: 7
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#1Hugh Ip (Guy's and St Thomas' NHS Foundation Trust)H-Index: 4
#2Wen Ling Woo (Whittington Hospital)
Last. Nicholas Hart (Guy's and St Thomas' NHS Foundation Trust)H-Index: 56
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A 79-year-old man was electively admitted for a Whipple's procedure for a pancreatic cancer. Following surgery, he was extubated, but subsequently developed a hospital-acquired pneumonia with multiple organ failure requiring admission to the intensive care unit for organ support. After a protracted period of failed weaning from mechanical ventilation, he was transferred to a regional weaning centre 7 months after the initial operation. Since the surgery, the patient had complained of abdominal b...
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#1Hugh Ip (Guy's and St Thomas' NHS Foundation Trust)H-Index: 4
#2Tariq Sethi (AstraZeneca)H-Index: 2
Abstract CD98 is implicated in a large number of cancers. CD98 regulates amino acid transport and integrin signaling, which are key drivers in tumor progression. The light chain in the CD98 heterodimer functions as an amino acid exchanger. Alongside the light chain, the heavy chain forms a heterocomplex at the plasma membrane to mediate signaling pathways. In this article, we review various approaches to blocking CD98 activity, which may lead to novel opportunities in cancer therapeutics.
9 CitationsSource