Mitsune Tanimoto
Okayama University
CancerInternal medicineSurgeryPathologyOncologyMolecular biologyImmunologyLung cancerChemotherapyHematopoietic stem cell transplantationCisplatinLeukemiaEpidermal growth factor receptorBone marrowGefitinibTransplantationCancer researchMedicineBiologyGastroenterology
Publications 617
#1Kazunori Ohnishi (Hamamatsu University School of Medicine)H-Index: 36
#2Ken Ohmachi (Tokai University)H-Index: 13
Last. Kensuke NaitoH-Index: 20
view all 17 authors...
The optimal combined chemotherapy regimen with rituximab has yet to be established for elderly patients with advanced-stage indolent B-cell lymphoma (B-NHL). A multicenter study was performed to evaluate the efficacy and toxicity of R-THP-COP therapy in elderly patients (aged 70-79 years) with newly diagnosed advanced-stage indolent B-NHL using the complete response rate (%CR) as the primary endpoint. Patients with newly diagnosed, clinical stage III/IV, indolent B-NHL, aged 70-79 years, with a ...
#1Sachiyo Okamoto (Okayama University)H-Index: 1
#2Nobuharu Fujii (Okayama University)H-Index: 20
Last. Yutaka Osuga (UTokyo: University of Tokyo)H-Index: 62
view all 8 authors...
BACKGROUND Worldwide, there has been a growing interest in oncofertility issues. In 2017, the Japanese Society of Clinical Oncology published clinical practice guidelines for fertility preservation (FP) in cancer patients. We conducted a questionnaire survey to explore the FP practices among hematologists before the publication of this guideline. METHODS We sent 427 designated cancer hospitals in Japan a questionnaire about FP treatment for patients with hematological malignancies between Januar...
1 CitationsSource
#1Kenichiro KudoH-Index: 10
#2Keita KawakadoH-Index: 1
Last. Mitsune TanimotoH-Index: 68
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The central nervous system efficacy of dacomitinib, a key agent used in the treatment of epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC), is unclear. We herein present our experience in the use of dacomitinib for the treatment of multiple brain metastatic lesions from EGFR-mutation-positive NSCLC in an elderly patient. This case report demonstrates that dacomitinib can be an essential treatment option for patients with brain metastases.
4 CitationsSource
#1Yuko Sanada (UTokyo: University of Tokyo)H-Index: 1
#2Miyuki Harada (UTokyo: University of Tokyo)H-Index: 28
Last. Yutaka Osuga (UTokyo: University of Tokyo)H-Index: 62
view all 18 authors...
Aim: The survival rates of cancer patients have greatly improved owing to the advances in oncology. The preservation of fertility in cancer patients is an important task. To determine the reality of cryopreservation of embryos, oocytes and ovarian tissue in cancer patients, large-scale survey analysis was performed in Japan. Methods: We sent 613 Japan Society of Obstetrics and Gynecology-certified assisted reproductive technology institutions a questionnaire about their experience of performing ...
6 CitationsSource
#1Daisuke Morichika (Okayama University)H-Index: 8
#2Nobuaki Miyahara (Okayama University)H-Index: 33
Last. Arihiko Kanehiro (Okayama University)H-Index: 25
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Retinoid X receptors (RXRs) are members of the nuclear receptor (NR) superfamily that mediate signalling by 9-cis retinoic acid, a vitamin A derivative. RXRs play key roles not only as homodimers but also as heterodimeric partners, e.g., for retinoic acid receptors, vitamin D receptors, and peroxisome proliferator-activated receptors. The NR family may also play important roles in the development of emphysema. However, the role of RXRs in the pathogenesis of emphysema is not well defined. We dev...
12 CitationsSource
#1Go Makimoto (Okayama University)H-Index: 7
#2Toshio Kubo (Okayama University)H-Index: 18
Last. Katsuyuki Kiura (Okayama University)H-Index: 68
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: The standard treatment for patients with locally advanced non-small-cell lung cancer (LA-NSCLC) is chemoradiotherapy (CRT), but surgical resection following induction CRT can extend overall survival in a select population. However, patients who survive longer are at risk of developing a second primary cancer (SPC). This is the first report to determine the incidence of SPC in survivors with LA-NSCLC after trimodal therapy. Between October 1997 and October 2013, 112 Stage III NSCLC patients und...
3 CitationsSource
The Japan Marrow Donor Program (JMDP) has facilitated unrelated peripheral blood stem cell transplantation (URPBSCT) since 2010. We conducted a prospective multicenter observational study to evaluate the feasibility of such transplantation. Between 2011 and 2014, 51 patients underwent URPBSCT from 8/8 allele-matched donors for hematological malignancies. The median age of the patients was 50 years; 21 had high-risk disease. Myeloablative conditioning regimens were used in 31 patients, and tacrol...
5 CitationsSource
#1Shuntaro Ikegawa (Okayama University)H-Index: 4
#2Ken-ichi Matsuoka (Okayama University)H-Index: 17
Last. Mitsune Tanimoto (Okayama University)H-Index: 68
view all 13 authors...
Creatinine clearance rate (Ccr) is a more accurate indicator of renal function than serum creatinine. Data are sparse regarding the prognostic value of renal impairment calculated using Ccr in patients who undergo allogeneic hematopoietic stem cell transplantation (allo-HSCT). We performed a retrospective analysis of 185 patients who underwent allo-HSCT. These patients were divided into two groups by Ccr (ml/min) before transplantation; one showed normal renal function (Ccr ≥ 60, n = 156) and th...
4 CitationsSource
#1Yoshinobu Maeda (Okayama University)H-Index: 29
#2Hisakazu Nishimori (Okayama University)H-Index: 11
Last. Mitsune Tanimoto (Okayama University)H-Index: 68
view all 18 authors...
The standard CHOP therapy for peripheral T-cell lymphoma has resulted in unsatisfactory outcomes and it is still not clear what is the optimal front-line therapy. We conducted a multicenter phase II study of dose-adjusted etoposide, doxorubicin, and cyclophosphamide with vincristine and prednisone (EPOCH) for untreated peripheral T-cell lymphoma patients. In this prospective study, 41 patients were treated with dose-adjusted-EPOCH as initial therapy: peripheral T-cell lymphoma-not otherwise spec...
19 CitationsSource
#1Shoichi KuyamaH-Index: 12
#2Nobuaki Ochi (Kawasaki Medical School)H-Index: 16
Last. Katsuyuki Kiura (Okayama University)H-Index: 68
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Abstract Introduction S-1 is an oral fluoropyrimidine-based combination of tegafur, gimeracil, and oteracil potassium. Although the combination of S-1 with carboplatin is a first-line chemotherapy regimen for advanced non-small cell lung cancer (NSCLC), the efficacy and safety of the regimen in the elderly remain unknown. Methods The patient inclusion criteria were previously untreated advanced NSCLC, wild-type epidermal growth factor receptor, aged 70 years or more, and a performance status (PS...
4 CitationsSource