Wolfgang Koenig
University of Ulm
Internal medicineEndocrinologySurgeryCardiologyProspective cohort studyCohort studyImmunologyHazard ratioInflammationType 2 diabetesCoronary artery diseaseDiseaseBody mass indexC-reactive proteinPopulationMyocardial infarctionRisk factorDiabetes mellitusMedicineBiology
783Publications
129H-index
60.9kCitations
Publications 756
Newest
#1Gorav Batra (Uppsala University)H-Index: 5
#2Tatevik Ghukasyan Lakic (Uppsala University)H-Index: 4
Last. Emil Hagström (Uppsala University)H-Index: 28
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Importance Inflammation promotes cardiovascular disease and anti-inflammatory treatment reduces cardiovascular events in patients with chronic coronary syndrome. Chronic kidney disease (CKD) is a risk factor for cardiovascular disease. It is unclear how inflammation mediated by interleukin 6 (IL-6) in patients with CKD is linked to cardiovascular disease. Objective To investigate associations between IL-6 and cardiovascular outcomes in patients with chronic coronary syndrome in association with ...
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#1Andrea Jaensch (University of Ulm)H-Index: 16
#2Ben Schöttker (DKFZ: German Cancer Research Center)H-Index: 64
Last. Dietrich Rothenbacher (University of Ulm)H-Index: 90
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While there is good evidence that symptoms of depression determine prognosis of patients with coronary heart disease (CHD), the role of psychological stress is less clear. We evaluated the prognostic value of stressful events in patients with initial myocardial infarction (MI) with respect to subsequent cardiovascular events. The KAROLA-study included patients with CHD who participated in an in-patient rehabilitation program. A total of 577 patients with initial MI were included and self-reporte...
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#1Linda P. Siziba (Leipzig University)H-Index: 2
#2Hermann Brenner (DKFZ: German Cancer Research Center)H-Index: 165
Last. Jon Genuneit (Leipzig University)H-Index: 47
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BACKGROUND The hormone leptin has been suggested to play a role in the respiratory and immune systems. Evidence on sex-specific concentrations of leptin in human milk and sex-specific associations with the development of asthma and wheeze has been put forward but is still scarce. OBJECTIVE To investigate whether male and female infants receive different levels of leptin through human milk and whether leptin is implicated in the development of asthma and wheeze in a sex-dependent manner using dat...
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#2Rory P. WilsonH-Index: 72
Last. Pascal Schlosser (University of Freiburg)H-Index: 7
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BACKGROUND Studies on the relationship between renal function and the human plasma proteome have identified several potential biomarkers. However, investigations have been conducted largely in European populations, and causality of the associations between plasma proteins and kidney function has never been addressed. METHODS A cross-sectional study of 993 plasma proteins among 2,882 participants in four studies of European and admixed ancestries (KORA, INTERVAL, HUNT, QMDiab) identified trans-et...
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#1Eliana Portilla-Fernandez (Erasmus University Medical Center)H-Index: 8
#2Shih-Jen Hwang (NIH: National Institutes of Health)H-Index: 81
Last. Symen Ligthart (Erasmus University Medical Center)H-Index: 27
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Common carotid intima-media thickness (cIMT) is an index of subclinical atherosclerosis that is associated with ischemic stroke and coronary artery disease (CAD). We undertook a cross-sectional epigenome-wide association study (EWAS) of measures of cIMT in 6400 individuals. Mendelian randomization analysis was applied to investigate the potential causal role of DNA methylation in the link between atherosclerotic cardiovascular risk factors and cIMT or clinical cardiovascular disease. The CpG sit...
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#1Alina BauerH-Index: 1
#2Astrid ZiererH-Index: 17
Last. Cornelia HuthH-Index: 35
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It is still unclear how genetic information, provided as single-nucleotide polymorphisms (SNPs), can be most effectively integrated into risk prediction models for coronary heart disease (CHD) to add significant predictive value beyond clinical risk models. For the present study, a population-based case-cohort was used as a trainingset (451 incident cases, 1488 noncases) and an independent cohort as testset (160 incident cases, 2749 noncases). The following strategies to quantify genetic informa...
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#1Pamela R. Matias-Garcia (TUM: Technische Universität München)H-Index: 2
#2Cavin K. Ward-Caviness (EPA: United States Environmental Protection Agency)H-Index: 19
Last. Melanie WaldenbergerH-Index: 62
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BACKGROUND The difference between an individual's chronological and DNA methylation predicted age (DNAmAge), termed DNAmAge acceleration (DNAmAA), can capture life-long environmental exposures and age-related physiological changes reflected in methylation status. Several studies have linked DNAmAA to morbidity and mortality, yet its relationship with kidney function has not been assessed. We evaluated the associations between seven DNAm aging and lifespan predictors (as well as GrimAge component...
1 CitationsSource
#1Cornelia Then (LMU: Ludwig Maximilian University of Munich)H-Index: 13
#2Christian Herder (HHU: University of Düsseldorf)H-Index: 88
Last. Jochen Seissler (LMU: Ludwig Maximilian University of Munich)H-Index: 30
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#1Mohamed A ElhadadH-Index: 5
#2Rory P. WilsonH-Index: 72
Last. Annette PetersH-Index: 142
view all 16 authors...
Background The metabolic syndrome (MetS), defined by the simultaneous clustering of cardio-metabolic risk factors, is a significant worldwide public health burden with an estimated 25% prevalence worldwide. The pathogenesis of MetS is not entirely clear and the use of molecular level data could help uncover common pathogenic pathways behind the observed clustering. Methods Using a highly multiplexed aptamer-based affinity proteomics platform, we examined associations between plasma proteins and ...
1 CitationsSource