Edith Hofer
Medical University of Graz
Genome-wide association studyPathologyMagnetic resonance imagingHyperintensityNeuroscienceCognitionGenetic associationDiseaseDementiaWhite matterPopulationStrokeGeneticsBrain sizeMedicineEvolutionary biologyBlood pressureLocus (genetics)BiologyGenetic architecture
Publications 86
#2Hideaki Suzuki (Imperial College London)H-Index: 10
Last. Stéphanie Debette (University of Bordeaux)H-Index: 51
view all 116 authors...
White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were associated with altered white matter integrity (p = 2.5×10-7) in brain images from 1,738 young healthy adults, providing insight into the lifetime imp...
#1Mathias Gorski (University of Regensburg)H-Index: 25
#2Bettina JungH-Index: 4
Last. Iris M. Heid (University of Regensburg)H-Index: 53
view all 175 authors...
#1Thomas Seifert-Held (Medical University of Graz)H-Index: 12
#2Katharina Eberhard (Medical University of Graz)H-Index: 9
Last. Maarten G. Lansberg (Stanford University)H-Index: 54
view all 7 authors...
#1Edith Hofer (Medical University of Graz)H-Index: 27
#2Gennady V. Roshchupkin (EUR: Erasmus University Rotterdam)H-Index: 10
Last. Sudha Seshadri (BU: Boston University)H-Index: 95
view all 99 authors...
1 CitationsSource
#1Maria J. Knol (EUR: Erasmus University Rotterdam)H-Index: 6
#2Dongwei Lu (University of Cambridge)
view all 63 authors...
Objective: To identify common genetic variants associated with the presence of brain microbleeds (BMB). Methods: We performed genome-wide association studies in 11 population-based cohort studies and 3 case-control or case-only stroke cohorts. Genotypes were imputed to the Haplotype Reference Consortium or 1000 Genomes reference panel. BMB were rated on susceptibility-weighted or T2*-weighted gradient echo magnetic resonance imaging sequences, and further classified as lobar, or mixed (including...
2 CitationsSource
#1Markus Kneihsl (Medical University of Graz)H-Index: 7
#2Edith Hofer (Medical University of Graz)H-Index: 27
Last. Thomas Gattringer (Medical University of Graz)H-Index: 18
view all 11 authors...
Background and Purpose: Previous studies suggested an association between increased intracranial arterial pulsatility and the severity of microangiopathic white matter hyperintensities (WMH). Howev...
#1Jasmin Rabensteiner (University of Graz)
#2Edith Hofer (Medical University of Graz)H-Index: 27
Last. Markus Herrmann (University of Graz)
view all 9 authors...
BACKGROUND Dementia, and in particular Alzheimer's disease (AD), is a debilitating progressive disease with high prevalence in our society. Vitamin B12 and folate deficiency are potential modifiable risk factors. However, previous studies reported inconsistent results. RESULTS The average concentrations of all biochemical markers were within the respective reference ranges. Cross-sectional and longitudinal analyses did not reveal significant associations between biochemical markers and cognitive...
1 CitationsSource
#1Anna DamulinaH-Index: 3
#2Lukas Pirpamer (LMU: Ludwig Maximilian University of Munich)H-Index: 1
Last. Christian LangkammerH-Index: 30
view all 12 authors...
In individuals with Alzheimer disease, 3-T MRI revealed that brain iron accumulation in the temporal lobe during a mean follow-up period of 17 months was associated with cognitive deterioration ind...
8 CitationsSource
#1Nicola J. Armstrong (Murdoch University)H-Index: 37
#2Karen A. Mather (UNSW: University of New South Wales)H-Index: 34
Last. Paul A. Nyquist (NIH: National Institutes of Health)H-Index: 22
view all 86 authors...
Background and Purpose: Periventricular white matter hyperintensities (WMH; PVWMH) and deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences in cause. In the first st...
9 CitationsSource
#1Jean Shin (U of T: University of Toronto)H-Index: 11
#2Shaojie Ma (Yale University)H-Index: 2
Last. Tomáš Paus (U of T: University of Toronto)H-Index: 93
view all 68 authors...
We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included th...
2 CitationsSource
Close Researchers