João F. Mano
University of Aveiro
Regenerative medicineSelf-healing hydrogelsGlass transitionBiophysicsBiomedical engineeringComposite materialNanotechnologyChemistryPolymer chemistryMaterials scienceBiomaterialChitosanDrug deliveryDifferential scanning calorimetryMembraneChemical engineeringTissue engineeringPolymerLayer by layerDynamic mechanical analysisCell biology
896Publications
105H-index
30.9kCitations
Publications 894
Newest
#1Maria C. Gomes (University of Aveiro)H-Index: 9
#2Dora C. S. Costa (University of Aveiro)H-Index: 6
Last. João F. Mano (University of Aveiro)H-Index: 105
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Platforms with liquid cores are extensively explored as cell delivery vehicles for cell-based therapies and tissue engineering. However, the recurrence of synthetic materials can impair its translation into the clinic. Inspired by the adhesive proteins secreted by mussels, liquefied capsule is developed using gelatin modified with hydroxypyridinones (Gel-HOPO), a catechol analogue with oxidant-resistant properties. The protein-based liquefied macrocapsule permitted the compartmentalization of li...
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#1Luís P. Ferreira (University of Aveiro)H-Index: 5
#2Vítor M. Gaspar (University of Aveiro)H-Index: 24
Last. João F. Mano (University of Aveiro)H-Index: 105
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Decellularized extracellular matrix (dECM) is emerging as a valuable tool for generating 3D in vitro tumor models that better recapitulate tumor-stroma interactions. However, the development of dECM-3D heterotypic microtumors exhibiting a controlled morphology is yet to be materialized. Precisely controlling microtumors morphologic features is key to avoid an inaccurate evaluation of therapeutics performance during preclinical screening. To address this, herein we employed ultra-low adhesion sur...
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#1M. Isabel Rial-Hermida (University of Aveiro)
#2Ana Rey-RicoH-Index: 22
Last. João F. Mano (University of Aveiro)H-Index: 105
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A plethora of applications using polysaccharides have been developed in recent years due to their availability as well as their frequent nontoxicity and biodegradability. These polymers are usually obtained from renewable sources or are byproducts of industrial processes, thus, their use is collaborative in waste management and shows promise for an enhanced sustainable circular economy. Regarding the development of novel delivery systems for biotherapeutics, the potential of polysaccharides is a...
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#1Daniela Bispo (University of Aveiro)H-Index: 2
#2Catarina S H Jesus (University of Aveiro)
Last. Ana M. Gil (University of Aveiro)H-Index: 54
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This review describes the use of metabolomics to study stem cell (SC) characteristics and function, excluding SCs in cancer research, suited to a fully dedicated text. The interest in employing metabolomics in SC research has consistently grown and emphasis is, here, given to developments reported in the past five years. This text informs on the existing methodologies and their complementarity regarding the information provided, comprising untargeted/targeted approaches, which couple mass spectr...
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#1Patrícia D. C. Costa (University of Aveiro)
#2Dora C. S. Costa (University of Aveiro)H-Index: 6
Last. João F. Mano (University of Aveiro)H-Index: 105
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#3Tiago R. Correia (University of Aveiro)H-Index: 2
#6Maria Isabel Rial-Hermida (University of Aveiro)H-Index: 1
The development of complex and large 3D vascularized tissue constructs remains the major goal of tissue engineering and regenerative medicine (TERM). To date, several strategies have been proposed to build functional and perfusable vascular networks in 3D tissue-engineered constructs to ensure the long-term cell survival and the functionality of the assembled tissues after implantation. However, none of them have been entirely successful in attaining a fully functional vascular network. Herein, ...
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#1Adérito J. R. Amaral (University of Aveiro)H-Index: 1
#2Vítor M. Gaspar (University of Aveiro)H-Index: 24
Last. João F. Mano (University of Aveiro)H-Index: 105
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The design of dynamically crosslinked hydrogel bioinks for three-dimensional (3D) bioprinting is emerging as a valuable strategy to advance the fabrication of mechanically tuneable cell-laden constructs for 3Din vitrodisease modelling and tissue engineering applications. Herein, a dynamic bioink comprising boronic acid-functionalised laminarin and alginate is explored for bioprinting 3D constructs under physiologically relevant conditions. The formulated bioink takes advantage of a double crossl...
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#1Nguyen Duc Tien (University of Oslo)H-Index: 1
Last. Håvard J. HaugenH-Index: 28
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Chitosan has many useful intrinsic properties (e.g., non-toxicity, antibacterial properties, and biodegradability) and can be processed into high-surface-area nanofiber constructs for a broad range of sustainable research and commercial applications. These nanofibers can be further functionalized with bioactive agents. In the food industry, for example, edible films can be formed from chitosan-based composite fibers filled with nanoparticles, exhibiting excellent antioxidant and antimicrobial pr...
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#1Pankaj Bharmoria (University of Aveiro)H-Index: 14
#2Meena Bisht (University of Aveiro)H-Index: 9
Last. Sónia P. M. Ventura (University of Aveiro)H-Index: 36
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The sustainable cellular delivery of the pleiotropic drug curcumin encounters drawbacks related to its fast autoxidation at the physiological pH, cytotoxicity of delivery vehicles and poor cellular uptake. A biomaterial compatible with curcumin and with the appropriate structure to allow the correct curcumin encapsulation considering its poor solubility in water, while maintaining its stability for a safe release was developed. In this work, the biomaterial developed started by the preparation o...
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#1Ana Rita SousaH-Index: 3
#2João F. Mano (University of Aveiro)H-Index: 105
Last. Mariana B. Oliveira (University of Aveiro)H-Index: 32
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Advances in allogeneic transplantation of solid organs and tissues depend on our understanding of mechanisms that mediate the prevention of graft rejection. For the past decades, clinical practice has established guidelines to prevent allograft rejection, which mostly rely on the intake of nontargeted immunosuppressants as the gold standard. However, such lifelong regimens have been reported to trigger severe morbidities and commonly fail in preventing late allograft loss. In this review, the bi...
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