Felicia D'Andrea
University of Pisa
Matrix metalloproteinaseTautomerIonic liquidMedicinal chemistryOrganic chemistryStereoselectivityChemistryGlycosideEpimerMoietyDisaccharideGalactoseLactoseDerivative (chemistry)Dimethyl acetalReagentYield (chemistry)BiochemistryRegioselectivityStereochemistryIntramolecular forceAnomerHydrolysis
129Publications
19H-index
997Citations
Publications 122
Newest
#1Luca GuglielmeroH-Index: 2
#2Angelica MeroH-Index: 2
Last. Lorenzo GuazzelliH-Index: 18
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#1Andrea MezzettaH-Index: 13
#2Luca GuglielmeroH-Index: 2
Last. Lorenzo GuazzelliH-Index: 18
view all 7 authors...
Benzimidazole dicationic ionic liquids (BDILs) have not yet been widely explored in spite of their potential. Therefore, two structurally related families of BDILs, paired with either bromide or bistriflimide anions and bearing alkyl spacers ranging from C3 to C6, have been prepared. Their thermal properties have been studied by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), while their electrical properties have been assessed by cyclic voltammetry (CV). TG analysi...
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#1Francesca Gado (UniPi: University of Pisa)H-Index: 7
#2Kawthar A. Mohamed (U of S: University of Saskatchewan)H-Index: 3
Last. Clementina Manera (UniPi: University of Pisa)H-Index: 26
view all 11 authors...
Abstract We previously reported the 2-oxopyridine-3-carboxamide derivative EC21a as the first small synthetic CB2R positive allosteric modulator which displayed antinociceptive activity in vivo in an experimental mouse model of neuropathic pain. Herein, we extended the structure-activity relationships of EC21a through structural modifications regarding the p-fluoro benzyl moiety at position 1 and the amide group in position 3 of the central core. The characterization in vitro was assessed throug...
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#1Salvatore Santamaria (Imperial College London)H-Index: 14
#2Doretta Cuffaro (UniPi: University of Pisa)H-Index: 5
Last. Josefin Ahnström (Imperial College London)H-Index: 16
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ADAMTS-5 is a major protease involved in the turnover of proteoglycans such as aggrecan and versican. Dysregulated aggrecanase activity of ADAMTS-5 has been directly linked to the etiology of osteoarthritis (OA). For this reason, ADAMTS-5 is a pharmaceutical target for the treatment of OA. ADAMTS-5 shares high structural and functional similarities with ADAMTS-4, which makes the design of selective inhibitors particularly challenging. Here we exploited the ADAMTS-5 binding capacity of β-N-acetyl...
4 CitationsSource
#1Chiara Arena (University of Bern)H-Index: 6
#2Francesca Gado (UniPi: University of Pisa)H-Index: 7
Last. Clementina Manera (UniPi: University of Pisa)H-Index: 5
view all 22 authors...
Multiple sclerosis is a chronic inflammatory demyelinating disorder of the central nervous system that eventually leads to progressive neurodegeneration and disability. Recent findings highlighted the emerging role of each target of the endocannabinoid system in controlling the symptoms and disease progression of multiple sclerosis. Therefore, multi-target modulators of the endocannabinoid system could provide a more effective pharmacological strategy as compared to the single target modulation....
4 CitationsSource
#1Elena Husanu (UniPi: University of Pisa)H-Index: 7
#2Angelica Mero (UniPi: University of Pisa)H-Index: 2
Last. Lorenzo Guazzelli (UniPi: University of Pisa)H-Index: 18
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The full utilization of agricultural waste and its recycle into a new chain of value are of primary importance for the development of a sustainable and profitable agricultural industry. Chestnut sh...
4 CitationsSource
#1Doretta Cuffaro (UniPi: University of Pisa)H-Index: 5
#2Elisa Nuti (UniPi: University of Pisa)H-Index: 25
Last. Armando Rossello (UniPi: University of Pisa)H-Index: 28
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Matrix metalloproteinases (MMPs) and A disintegrin and Metalloproteinase (ADAMs) are zinc-dependent endopeptidases belonging to the metzincin superfamily. Upregulation of metzincin activity is a major feature in many serious pathologies such as cancer, inflammations, and infections. In the last decades, many classes of small molecules have been developed directed to inhibit these enzymes. The principal shortcomings that have hindered clinical development of metzincin inhibitors are low selectivi...
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#1Doretta Cuffaro (UniPi: University of Pisa)H-Index: 5
#2Felicia D'Andrea (UniPi: University of Pisa)H-Index: 19
Last. Armando Rossello (UniPi: University of Pisa)H-Index: 28
view all 7 authors...
This study reports an ionic liquid (IL) promoted green method to obtain diaryl thioethers useful as key intermediates for the synthesis of matrix metalloproteinase (MMP) inhibitors. The synthetic p...
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#1Salvatore Santamaria (Imperial College London)H-Index: 14
#2Doretta Cuffaro (UniPi: University of Pisa)H-Index: 5
Last. Josefin Ahnstroem (Imperial College London)
view all 10 authors...
ADAMTS-5 is a major protease involved in the turnover of proteoglycans such as aggrecan and versican. Its aggrecanase activity has been directly linked to the etiology of osteoarthritis (OA), identifying ADAMTS-5 as a pharmaceutical target for OA treatment. However, most existing ADAMTS-5 inhibitors target its active site and therefore suffer from poor selectivity. Here, using a novel approach, we have designed a new class of sugar-based arylsulfonamide inhibitors, which are selective for ADAMTS...
Source
#1Felicia D'Andrea (UniPi: University of Pisa)H-Index: 19
#2Stefania Sartini (UniPi: University of Pisa)H-Index: 20
Last. Susanna Nencetti (UniPi: University of Pisa)H-Index: 18
view all 11 authors...
: Aldose reductase is a key enzyme in the development of long term diabetic complications and its inhibition represents a viable therapeutic solution for people affected by these pathologies. Therefore, the search for effective aldose reductase inhibitors is a timely and pressing challenge. Herein we describe the access to a novel class of oxyimino derivatives, obtained by reaction of a 1,5-dicarbonyl substrate with O-(arylmethyl)hydroxylamines. The synthesised compounds proved to be active agai...
2 CitationsSource