Joshua P. Gray
University of Maryland, College Park
EndocrinologyReductaseMolecular biologyCytochrome P450 reductaseChemistryAdverse effectAutophagyIn vivoOxidative stressInflammationInsulinSulfur mustardSuperoxideDeferasiroxReactive oxygen speciesBiochemistryMedicineNAD+ kinaseBiologyPharmacology
75Publications
20H-index
1,138Citations
Publications 56
Newest
#1Shondra M Neumeister (UMD: University of Maryland, College Park)
#2Joshua P Gray (UMD: University of Maryland, College Park)
Last. Joshua P. Gray (UMD: University of Maryland, College Park)H-Index: 20
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The Strategic National Stockpile (SNS) serves as a repository of materiel, including medical countermeasures (MCMs), that would be used to support the national health security response to a chemical, biological, radiological, or nuclear (CBRN) incident, either natural or terrorism-related. To support and advance the SNS, the National Institutes of Health (NIH) manages targeted investigatory research portfolios, such as Countermeasures Against Chemical Terrorism (CounterACT) for chemical agents, ...
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#1Joshua P. GrayH-Index: 20
Last. Steven W. MillwardH-Index: 15
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In recent decades it has become increasingly clear that induction of autophagy plays an important role in the development of treatment resistance and dormancy in many cancer types. Unfortunately, chloroquine (CQ) and hydroxychloroquine (HCQ), two autophagy inhibitors in clinical trials, suffer from poor pharmacokinetics and high toxicity at therapeutic dosages. This has prompted intense interest in the development of targeted autophagy inhibitors to re-sensitize disease to treatment with minimal...
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#1Robert P. CasillasH-Index: 20
#2Neera Tewari-Singh (MSU: Michigan State University)H-Index: 1
Last. Joshua P. Gray (United States Coast Guard Academy)H-Index: 20
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Chemical exposure emergencies posing a serious threat to the health and survival of civilians can be caused by terrorism events or industrial accidents. The National Institutes of Health (NIH) deve...
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#1Daniel J. KlionskyH-Index: 139
Last. Chun Kit Tong (Hong Kong Baptist University)H-Index: 1
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In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, ...
29 CitationsSource
#1Brian J. Engel (University of Texas MD Anderson Cancer Center)H-Index: 8
#2Brian J. Grindel (University of Texas MD Anderson Cancer Center)H-Index: 1
Last. Steven W. Millward (University of Texas MD Anderson Cancer Center)H-Index: 15
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Abstract Solid-phase resins functionalized with poly-deoxythymidine (dT) oligos facilitate purification of poly-adenylated molecules from solution through high affinity, high selectivity base-pairing interactions. These resins are commonly used to purify messenger RNA (mRNA) from complex biological mixtures as well as mRNA-protein fusion molecules for mRNA Display selections. Historically, dT-conjugated cellulose was the primary resin for poly-dA purification, but its scarcity has prompted the d...
2 CitationsSource
#1Sidhartha D. RayH-Index: 2
#1Sidhartha D. RayH-Index: 33
Last. Sidney J. StohsH-Index: 69
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#1Joshua P. Gray (United States Coast Guard Academy)H-Index: 20
#2Christine P. Curran (Northern Kentucky University)H-Index: 12
Last. Betty J. Eidemiller (Society of Toxicology)H-Index: 2
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: The Society of Toxicology announces the development of a Learning Framework (https://www.toxicology.org/education/docs/SOT-Toxicology-Learning-Objectives.pdf) for undergraduate toxicology that will facilitate the development and sharing of evidence-based teaching materials for undergraduate toxicology educators throughout the world. This Learning Framework was modeled on the "Vision and Change Report" (www.visionandchange.org), an effort of the National Science Foundation and American Associat...
2 CitationsSource
#1Margie N. Sutton (University of Texas MD Anderson Cancer Center)H-Index: 8
#2Gilbert Y. Huang (University of Texas MD Anderson Cancer Center)H-Index: 8
Last. Robert C. BastH-Index: 138
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Autophagy can protect cancer cells from acute starvation and enhance resistance to chemotherapy. Previously, we reported that autophagy plays a critical role in the survival of dormant, drug resistant ovarian cancer cells using human xenograft models and correlated the up-regulation of autophagy and DIRAS3 expression in clinical samples obtained during “second look” operations. DIRAS3 is an imprinted tumor suppressor gene that encodes a 26 kD GTPase with homology to RAS that inhibits cancer cell...
7 CitationsSource
#1Joshua P. Gray (United States Coast Guard Academy)H-Index: 20
#2Jeeseon Rosa Kim (Touro College)H-Index: 1
Last. Sidhartha D. Ray (Rowan University)H-Index: 4
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Abstract The Side Effects of Drugs Annuals forms a series of volumes in which the adverse effects of drugs and adverse reactions to them are surveyed. The series supplements the contents of Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. This review of the January 2016–December 2016 publications on metal antagonists and selected metals includes ammonium tetrathiomolybdate, deferasirox, deferiprone, deferoxamine/desferrioxamine, deferitaz...
3 CitationsSource
#1Paramita Basu (Touro College)H-Index: 3
#2Rajesh VadlapatlaH-Index: 2
Last. Joshua P. Gray (United States Coast Guard Academy)H-Index: 20
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Abstract Medical devices and technologies play a vital role in improving outcomes of treatment, disease prevention and quality of healthcare. These technologies have applications in improving healthcare delivery as well as patient outcomes and are utilized for many disease states including diagnosis, clinical monitoring, treatment and prevention. Major goals are to improve functioning of organs and tissues, drug design and development, expanding viability and efficacy of drugs, and development o...
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