Akio Inui
Kagoshima University
CancerInternal medicineEndocrinologyReceptorChemistryHypothalamusOrexigenicCachexiaPancreatic polypeptideAnorexiaInsulinGhrelinLeptinGastric emptyingObesityDiabetes mellitusMedicineAppetiteBiologyNeuropeptide Y receptor
384Publications
72H-index
14.6kCitations
Publications 389
Newest
#1Namiko Kawamura (Kadai: Kagoshima University)H-Index: 2
#2Ela Novianti (Kadai: Kagoshima University)H-Index: 1
Last. Akio Inui (Kadai: Kagoshima University)H-Index: 72
view all 7 authors...
The mesolimbic dopamine system is important for the rewarding and motivational aspects of consuming rewarding and palatable food. Nicotinic receptors are present in the mesolimbic dopamine system and enhance the reinforcement of drugs of abuse. In this study, we examined the involvement of nicotine receptor subtypes in sucrose addiction in a sucrose preference paradigm. Sucrose preference and intake in mice increased in proportion to stepwise increases in sucrose concentrations. Moreover, sucros...
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#1Ela Novianti (LIPI: Indonesian Institute of Sciences)H-Index: 1
#2Goro Katsuura (Kadai: Kagoshima University)H-Index: 8
Last. Akio Inui (Kadai: Kagoshima University)H-Index: 72
view all 5 authors...
Abstract null null Atractylenolide-III (AIII), a sesquiterpene compound isolated from the rhizome of Atractylodes macrocephala, has been reported to have anti-inflammatory effects in the peripheral organs. However, its effects on brain inflammation remain elusive. The present study investigated the effects of AIII on the response to lipopolysaccharide (LPS) in mouse microglia and clarified the underlying mechanism. In this study, treatment of MG6 cells with AIII (100 μM) significantly decreased ...
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#1Masahiro Ohsawa (Nagoya City University)H-Index: 22
#2Toshiaki Makino (Nagoya City University)H-Index: 18
Last. Akio Inui (Kadai: Kagoshima University)H-Index: 72
view all 4 authors...
Cancer cachexia results in the discontinuation of aggressive cancer therapy, and halting its progression has a significant effect on the survival rate and quality of life of patients with cancer. Currently, there are few therapies to control or slow down the progression of cancer cachexia. Although traditional Japanese Kampo medicine is widely used to support aggressive cancer therapy, the relevant scientific evidence is limited. Additionally, Kampo medicines are based on historical experience. ...
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#1Mika Sakaki (Kadai: Kagoshima University)H-Index: 1
#2Kenji HaraiH-Index: 1
Last. Akio Inui (Kadai: Kagoshima University)H-Index: 72
view all 7 authors...
Kampo medicines contain many kinds of herbal drugs. Chinpi and Kippi, dried citrus peels, are components of a substantial number of Kampo medicine. They contain abundant flavonoids and studies on hesperidin, narirutin, and nobiletin as active ingredient have been conducted. Conversely, in Kagoshima prefecture, located in the southwestern part of the Japanese Islands, various citrus products are cultivated. Among them, Tankan and Daimasaki are specialies. In this study, we conducted high- perform...
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#1Momoko Kawabe (Kadai: Kagoshima University)H-Index: 1
#2Akito Hayashi (Kadai: Kagoshima University)H-Index: 1
Last. Kazuhiro Shiozaki (Kadai: Kagoshima University)H-Index: 18
view all 5 authors...
Abstract Anxiety induced by excess mental or physical stress is deeply involved in the onset of human psychiatric diseases such as depression, bipolar disorder, and panic disorder. Recently, Kampo medicines have received focus as antidepressant drugs for clinical use because of their synergistic and additive effects. Thus, we evaluated the anxiolytic activity of Ninjinyoeito (NYT) using neuropeptide Y-knockout (NPY-KO) zebrafish that exhibit severe anxiety responses to acute stress. Adult NPY-KO...
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#1Keizaburo OgataH-Index: 2
#2Ken Ichiro Koyama (Fukuoka Prefectural University)
Last. Akihiro AsakawaH-Index: 30
view all 12 authors...
The purposes of this study were as follows: to compare premorbid IQ with present IQ in patients with more severe anorexia nervosa restricting type (AN-R) and to investigate the relationship between decreasing IQ and symptoms in patients with severe AN-R. Twenty-two participants were recruited (12 were AN-R patients; 10 were healthy controls). The average BMI in AN-R patients and healthy controls was 12.65 and 19.82, respectively. We assessed the outcomes using the Wechsler Adult Intelligence Sca...
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#1Namiko Kawamura (Kadai: Kagoshima University)H-Index: 2
#2Goro Katsuura (Kadai: Kagoshima University)H-Index: 8
Last. Akihiro Asakawa (Kadai: Kagoshima University)H-Index: 30
view all 6 authors...
Introduction A diet high in saturated fat is well known to affect neuronal function and contribute to cognitive decline in experimental animals and humans. Fractalkine released from neurons acts on its receptor, CX3C chemokine receptor 1 (CX3CR1), in the microglia to regulate several brain functions. The present study addressed whether fractalkine-CX3CR1 signaling in the brain, especially the hippocampus, contributes to the cognitive deficits observed in diet-induced obese (DIO) mice. Research d...
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#2Hidenori AraiH-Index: 73
Last. Akio Inui (Kadai: Kagoshima University)H-Index: 72
view all 3 authors...
Anamorelin is a ghrelin receptor agonist that can be administered orally and thought to improve cancer cachexia by improving appetite and increasing serum insulin-like growth factor-1. Anamorelin was not approved for use in Europe. In contrast, the use of anamorelin for cancer cachexia in four types of cancer (non-small cell lung cancer, gastric cancer, pancreatic cancer, and colorectal cancer) was approved in Japan on 11 December 2020. Phase 2 trial (ONO-7643-04) for the treatment of patients w...
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#1Natasya Trivena Rokot (Kadai: Kagoshima University)H-Index: 4
#2Koji Ataka (Kadai: Kagoshima University)H-Index: 17
Last. Akihiro Asakawa (Kadai: Kagoshima University)H-Index: 30
view all 10 authors...
Abstract Patients with AN often express psychological symptoms such as body image distortion, cognitive biases, abnormal facial recognition, and deficits in working memory. However, the molecular mechanisms underlying the impairment of cognitive behaviors in AN remain unknown. In the present study, we measured cognitive behavior using novel object recognition (NOR) tasks and mRNA expressions in hypothalamic neuropeptides in female C57BL/6 J mice with activity-based anorexia (ABA). Additionally, ...
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#1Akio Inui (Kadai: Kagoshima University)H-Index: 72
#2Goro KatsuuraH-Index: 8
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