Tram T. Dang
Nanyang Technological University
Self-healing hydrogelsBiomedical engineeringCellControlled releaseNanotechnologyChemistryMaterials scienceCell encapsulationIn vivoBiocompatibilityInsulinDrug deliveryDrugDexamethasoneTransplantationCore shellTissue engineeringDiabetes mellitusEncapsulation (networking)Cell biologyPharmacology
26Publications
12H-index
1,839Citations
Publications 18
Newest
#1Dang T. Nguyen (NTU: Nanyang Technological University)H-Index: 2
#2Bob Hartadhi Tji Soeranaya (NTU: Nanyang Technological University)H-Index: 1
Last. Tram T. Dang (NTU: Nanyang Technological University)H-Index: 12
view all 4 authors...
Systemic drug administration has conventionally been prescribed to alleviate persistent local inflammation which is prevalent in chronic diseases. However, this approach is associated with drug-induced toxicity, particularly when the dosage exceeds that necessitated by pathological conditions of diseased tissues. Herein, we developed a modular hybrid hydrogel which could be triggered to release an anti-inflammatory drug upon exposure to elevated protease activity associated with inflammatory dis...
2 CitationsSource
#1Yang Chen (NTU: Nanyang Technological University)H-Index: 1
#2Dang T. Nguyen (NTU: Nanyang Technological University)H-Index: 2
Last. Tram T. Dang (NTU: Nanyang Technological University)H-Index: 12
view all 5 authors...
Transplantation of immuno-isolated islets is a promising strategy to restore insulin-secreting function in patients with Type 1 diabetes. However, the clinical translation of this treatment approach remains elusive due to the loss of islet viability resulting from hypoxia at the avascular transplantation site. To address this challenge, we designed non-spherical islet-like microtissues and investigated the effect of their geometries on cellular viability. Insulin-secreting microtissues with diff...
2 CitationsSource
#1Tong San TanH-Index: 1
#2Yi Zhen NgH-Index: 2
Last. E. Birgitte LaneH-Index: 51
view all 8 authors...
Abstract The discovery of the causative link between keratin mutations and a growing number of human diseases opened the way for a better understanding of the function of the whole intermediate filament families of cytoskeleton proteins. This chapter describes analytical approaches to identification and interpretation of the consequences of keratin mutations, from the clinical and diagnostic level to cells in tissue culture. Intermediate filament pathologies can be accurately diagnosed from skin...
5 CitationsSource
#1Tram T. Dang (MIT: Massachusetts Institute of Technology)H-Index: 12
#2Mehdi Nikkhah (MIT: Massachusetts Institute of Technology)H-Index: 36
Last. Ali Khademhosseini (Wyss Institute for Biologically Inspired Engineering)H-Index: 147
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Abstract Polymeric biomaterials have found increasing applications in implantable prostheses to replace damaged tissues and body parts or supplement their defective functions. In this chapter, we describe the principal biological and mechanical challenges in the selection of suitable polymers for the design of prosthetic devices. We also discuss the use of polymeric biomaterials in existing cardiovascular, orthopedic, ophthalmologic, and dental prostheses and highlight emerging directions in the...
11 CitationsSource
#1Su Ryon Shin (Wyss Institute for Biologically Inspired Engineering)H-Index: 59
#2Behnaz Aghaei-Ghareh-Bolagh (MIT: Massachusetts Institute of Technology)H-Index: 2
Last. Ali Khademhosseini (Wyss Institute for Biologically Inspired Engineering)H-Index: 147
view all 11 authors...
Tissue engineering involves the design and creation of functional substitutes for damaged tissues and organs.[1] To reach its potential, however, tissue engineering requires effective organization of cells into tissues with morphological and physiological features resembling those in vivo.[2] This process might be aided by incorporating specific nanomaterials into hydrogel scaffolds to mimic the characteristics of native tissues.[3-5] Desirable composite or hybrid scaffold properties include tun...
182 CitationsSource
#1Zhen Gu (MIT: Massachusetts Institute of Technology)H-Index: 77
#2Tram T. Dang (Harvard University)H-Index: 12
Last. Daniel G. Anderson (MIT: Massachusetts Institute of Technology)H-Index: 119
view all 9 authors...
A glucose-responsive closed-loop insulin delivery system represents the ideal treatment of type 1 diabetes mellitus. In this study, we develop uniform injectable microgels for controlled glucose-responsive release of insulin. Monodisperse microgels (256 ± 18 μm), consisting of a pH-responsive chitosan matrix, enzyme nanocapsules, and recombinant human insulin, were fabricated through a one-step electrospray procedure. Glucose-specific enzymes were covalently encapsulated into the nanocapsules to...
225 CitationsSource
#1Tram T. Dang (MIT: Massachusetts Institute of Technology)H-Index: 12
#2Anh V. Thai (MIT: Massachusetts Institute of Technology)H-Index: 2
Last. Daniel G. Anderson (MIT: Massachusetts Institute of Technology)H-Index: 119
view all 14 authors...
Immuno-isolation of islets has the potential to enable the replacement of pancreatic function in diabetic patients. However, host response to the encapsulated islets frequently leads to fibrotic overgrowth with subsequent impairment of the transplanted grafts. Here, we identified and incorporated anti-inflammatory agents into islet-containing microcapsules to address this challenge. In vivo subcutaneous screening of 16 small molecule anti-inflammatory drugs was performed to identify promising co...
66 CitationsSource
#1Zhen Gu (MIT: Massachusetts Institute of Technology)H-Index: 77
#2Alex A. AimettiH-Index: 10
Last. Daniel G. AndersonH-Index: 119
view all 9 authors...
Diabetes mellitus, a disorder of glucose regulation, is a global burden affecting 366 million people across the world. An artificial “closed-loop” system able to mimic pancreas activity and release insulin in response to glucose level changes has the potential to improve patient compliance and health. Herein we develop a glucose-mediated release strategy for the self-regulated delivery of insulin using an injectable and acid-degradable polymeric network. Formed by electrostatic interaction betwe...
272 CitationsSource
#1M. M. Ma (MIT: Massachusetts Institute of Technology)H-Index: 21
#1Minglin Ma (Boston Children's Hospital)H-Index: 34
Last. Daniel G. AndersonH-Index: 119
view all 15 authors...
4 CitationsSource
#1M. M. Ma (MIT: Massachusetts Institute of Technology)H-Index: 21
#1Minglin Ma (MIT: Massachusetts Institute of Technology)H-Index: 34
Last. Daniel G. AndersonH-Index: 119
view all 15 authors...
Hydrogel microcapsules have been extensively investigated for encapsulation of living cells or cell aggregates for tissue engineering and regenerative medicine.1,2,3 In general, capsules are designed to allow facile diffusion of oxygen and nutrients to the encapsulated cells, while releasing the therapeutic proteins secreted by the cells, and to protect the cells from attack by the immune system. These have been developed as potential therapeutics for a range of diseases including type I diabete...
107 CitationsSource