Dahai Hu
Fourth Military Medical University
Downregulation and upregulationEndocrinologySurgeryPathologyMolecular biologyGene knockdownChemistryApoptosisImmunologyInflammationHypertrophic scarWound healingFibrosisStem cellCancer researchMedicineProtein kinase BPI3K/AKT/mTOR pathwayBiologyCell biology
208Publications
26H-index
2,202Citations
Publications 206
Newest
#1Yue‐Hua Li (Xi'an Jiaotong University)
#2Jiaomei YangH-Index: 2
Last. Zhi‐Dong Wang (Xi'an Jiaotong University)
view all 5 authors...
BACKGROUND Hypertrophic scar is a common complication in would healing process, and how to effectively prevent and treat it has been a hot and difficult research issue. Previous studies have showed that botulinum toxin type A (BTA) has effects on the prevention and treatment of hypertrophic scar, but little is known about the specific mechanisms. OBJECTIVE This study aimed to explore the potential mechanisms of BTA on the inhibition of hypertrophic scar formation. METHODS Hypertrophic scar-deriv...
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#1Ming ZhaoH-Index: 2
#2Jihong ShiH-Index: 13
Last. Dahai HuH-Index: 26
view all 8 authors...
Graphene is a new type of carbon nanomaterial discovered after fullerene and carbon nanotube. Due to the excellent biological properties such as biocompatibility, cell proliferation stimulating, and antibacterial properties, graphene and its derivatives have become emerging candidates for the development of novel cutaneous wound dressings and composite scaffolds. On the other hand, pre-clinical research on exosomes derived from mesenchymal stem cells (MSC-Exos) has been intensified for cell-free...
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#1Yan Li (Fourth Military Medical University)H-Index: 28
#2Jian Zhang (Fourth Military Medical University)H-Index: 33
Last. Dahai Hu (Fourth Military Medical University)H-Index: 26
view all 14 authors...
BACKGROUND Hypertrophic scar (HS) is a fibro-proliferative disorder of dermis after burn or trauma and usually leads to esthetic disfiguration and functionary impairment for patients. Emerging evidences demonstrated ADSC-Exo could alleviate the visceral fibrosis, but little attention had been paid to its role in skin fibrosis. In the study, we would explore the effect of ADSC-Exo on HS and investigated the exact mechanism underlying the properties. METHODS ADSC-Exo were isolated, identified, and...
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#1H Y Zhao (Fourth Military Medical University)
#2J Q Han (Fourth Military Medical University)
Last. Dahai Hu (Fourth Military Medical University)H-Index: 26
view all 8 authors...
Objective: To observe the effects of continuous passive motion (CPM) system combined with functional training and pressure gloves in treating early scar contracture after burn on the back of the hand. Methods: A retrospective cohort study was conducted in 43 patients who met the inclusion criteria and were admitted to the First Affiliated Hospital of Air Force Medical University from June 2017 to December 2019 with scar contracture after partial-thickness to full-thickness burn on the back of th...
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#1Fu Han (Fourth Military Medical University)H-Index: 13
#2Zhenzhen Li (Fourth Military Medical University)H-Index: 8
Last. Dahai Hu (Fourth Military Medical University)H-Index: 26
view all 7 authors...
The present study sought to investigate the association between silent information regulator 1 (SIRT1) and autophagy during systemic inflammatory response syndrome following burn injury. The experimental burn model in mice and macrophages were established. SIRT1 mRNA expression was quantified by quantitative real-time PCR. The protein levels of SIRT1 and the conversion of light chain 3 (LC3)-I to LC3-II were determined by western blot analysis. The formation of autophagosomes was assessed by gre...
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#1Kuo Shen (Fourth Military Medical University)H-Index: 2
#2Yanhui Jia (Fourth Military Medical University)H-Index: 10
Last. Dahai Hu (Fourth Military Medical University)H-Index: 26
view all 12 authors...
ADSCs exosomes, an important means of intercellular communication, can regulate an array of biological processes, including promoting tissue repairs and regeneration, and attenuating inflammation. In this study, we found that ADSCs exosomes could polarize macrophage to an anti-inflammatory phenotype via regulating the expression of Nrf2 and HO-1, and improve inflammatory reaction and injury of multi-organ in sepsis. We revealed that ADSCs exosomes could alleviate LPS induced accumulation of ROS ...
1 CitationsSource
#1Liang Luo (Fourth Military Medical University)H-Index: 4
Last. Dahai Hu
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Human adipose-derived stromal cells (ADSCs) are receiving unprecedented attention as a potential cellular source for regenerative medicine-based therapies against various diseases and conditions. However, there still have significant issues concerning the translational development of ADSC-based therapies, such as its heterogeneity and being prone to aging. We developed a new simple and economical 3D semi-suspended expansion method in which 3D spheroids reside on an ADSC-derived self-feeder cell ...
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#1Hua-Yu Zhu (Fourth Military Medical University)H-Index: 13
#2Jun Li (Fourth Military Medical University)H-Index: 4
Last. Dahai Hu (Fourth Military Medical University)H-Index: 26
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Mechanical stimuli on cells and mechanotransduction are essential in many biological and pathological processes. Glucocorticoid is an important hormone, roles, and mechanisms of which in cellular mechanotransduction remain unknown. Here, we report that glucocorticoid counteracted cellular mechanoresponses dependently on a novel long noncoding RNA (lncRNA), LINC01569. Further, LINC01569 mediated glucocorticoid effects on mechanotransduction by destabilizing messenger RNA (mRNA) of mechanosensors ...
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#1Xiaozhi Bai (Fourth Military Medical University)H-Index: 21
#2Ting He (Fourth Military Medical University)H-Index: 10
Last. Dahai Hu (Fourth Military Medical University)H-Index: 26
view all 12 authors...
Severe inflammation can lead to multiple organ dysfunction syndrome, which has high mortality. Adipose-derived stem cells have been shown to affect the inflammatory response of macrophages. However, the molecular mechanism of the anti-inflammatory capacity of adipose-derived stem cells (ADSCs) remains to be understood. In the present study, a macrophage inflammation model was established by LPS, and treated with different volumes of ADSC supernatant. Then, we investigated the key genes in the LP...
1 CitationsSource
#1Jihong Shi (Fourth Military Medical University)H-Index: 13
#2Shan Shi (Fourth Military Medical University)H-Index: 4
Last. Hao Guan (Fourth Military Medical University)H-Index: 16
view all 13 authors...
Hypertrophic scar (HS) is a severe fibrotic skin disease. It has always been a major problem in clinical treatment, mainly because its pathogenesis has not been well understood. The roles of bacterial contamination and prolonged wound inflammation were considered significant. IL-10 is a potent anti-inflammatory cytokine and plays a pivotal role in wound healing and scar formation. Here, we investigate whether IL-10 alleviates lipopolysaccharide (LPS)-induced inflammatory response and skin scarri...
1 CitationsSource