Marnie Potgieter
University of Pretoria
AdipogenesisMicrobiomeCellStromal cellAdipose tissueChemistryAncient DNAMesenchymal stem cellImmunologyAdipocyteResveratrolDysbiosisCoenzyme Q10DysferlinopathySkeletal muscleDormancyDysferlinEvolutionary biologyBiologyCell biology
20Publications
9H-index
474Citations
Publications 21
Newest
#1Riaan F. Rifkin (University of Pretoria)H-Index: 11
#2Surendra Vikram (University of Pretoria)H-Index: 13
Last. Anders J. Hansen (UCPH: University of Copenhagen)H-Index: 34
view all 17 authors...
BACKGROUND: The archaeological incidence of ancient human faecal material provides a rare opportunity to explore the taxonomic composition and metabolic capacity of the ancestral human intestinal microbiome (IM). Here, we report the results of the shotgun metagenomic analyses of an ancient South African palaeo-faecal specimen. METHODS: Following the recovery of a single desiccated palaeo-faecal specimen from Bushman Rock Shelter in Limpopo Province, South Africa, we applied a multi-proxy analyti...
4 CitationsSource
#1Riaan F. Rifkin (University of Pretoria)H-Index: 11
#2Surendra Vikram (University of Pretoria)H-Index: 13
Last. Anders J. Hansen (UCPH: University of Copenhagen)H-Index: 34
view all 17 authors...
The archaeological incidence of ancient human faecal material provides a rare opportunity to explore the taxonomic composition and metabolic capacity of the ancestral human intestinal microbiome (IM). Following the recovery of a single desiccated palaeo-faecal specimen from Bushman Rock Shelter in Limpopo Province, South Africa, we applied a multi-proxy analytical protocol to the sample. Our results indicate that the distal IM of the Neolithic Middle Iron Age (c. AD 1485) Bantu-speaking individu...
Source
#1Jeffrey J. ChalmersH-Index: 47
view all 10 authors...
#1Diego J. Castillo (University of Pretoria)H-Index: 1
#2Riaan F. Rifkin (University of Pretoria)H-Index: 11
Last. Marnie Potgieter (University of Pretoria)H-Index: 9
view all 4 authors...
The blood that flows perpetually through our veins and arteries performs numerous functions essential to our survival. Besides distributing oxygen, this vast circulatory system facilitates nutrient transport, deters infection and dispenses heat throughout our bodies. Since human blood has traditionally been considered to be an entirely sterile environment, comprising only blood-cells, platelets and plasma, the detection of microbes in blood was consistently interpreted as an indication of infect...
48 CitationsSource
#1James Kim (OSU: Ohio State University)H-Index: 2
#2Jenifer Gómez-Pastora (OSU: Ohio State University)H-Index: 1
Last. Jeffrey J. Chalmers (OSU: Ohio State University)H-Index: 47
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: The presence of iron in circulating monocytes is well known as they play essential roles in iron recycling. Also, the storage of this metal as well as its incorrect uptake and/or release are important data to diagnose different pathologies. It has been demonstrated that iron storage in human blood cells can be measured through their magnetic behavior with high accuracy; however, the magnetic characteristics of monocytes have not been reported so far to the best of our knowledge. Therefore, in ...
1 CitationsSource
Last. Michael S. PepperH-Index: 73
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S1 File. Figure A: Chronic inflammation in the test animals over the trial period. Figure B: Acute inflammation in the test animals over the trial period. Figure C: Tissue necrosis in the test animals over the trial period. Figure D: Fibrosis in the test animals over the trial period. Figure E: Granulomatous/foreign body response in the test animals over the trial period. Figure F: Representative TEMs of skin biopsies of particles group (A) and particles+MEFs group (B) in the in vivo experiment ...
4 CitationsSource
#1Danielle de Villiers (University of Pretoria)H-Index: 2
#2Marnie Potgieter (University of Pretoria)H-Index: 9
Last. Michael S. Pepper (University of Pretoria)H-Index: 73
view all 6 authors...
Interest in reactive oxygen species and adipocyte differentiation/adipose tissue function is steadily increasing. This is due in part to a search for alternative avenues for combating obesity, which results from the excess accumulation of adipose tissue. Obesity is a major risk factor for complex disorders such as cancer, type 2 diabetes, and cardiovascular diseases. The ability of mesenchymal stromal/stem cells (MSCs) to differentiate into adipocytes is often used as a model for studying adipog...
9 CitationsSource
#1Riaan F. Rifkin (University of Pretoria)H-Index: 11
#2Marnie Potgieter (University of Pretoria)H-Index: 9
Last. Don A. Cowan (University of Pretoria)H-Index: 52
view all 4 authors...
The recent discovery that malignant neoplastic lesions date back nearly 2 million years ago not only highlights the antiquity of cancer in the human lineage, it also provides remarkable insight into ancestral hominin disease pathology. Using these Early Pleistocene examples as a point of departure, we emphasise the prominent role of viral and bacterial pathogens in oncogenesis and evaluate the impact of pathogens on human evolutionary processes in Africa. In the Shakespearean vernacular ‘what's ...
7 CitationsSource
#1Carla Dessels (South African Medical Research Council)H-Index: 5
#2Marnie Potgieter (South African Medical Research Council)H-Index: 9
Last. Michael S. Pepper (South African Medical Research Council)H-Index: 73
view all 3 authors...
Adipose-derived stromal cells (ASCs) are being used extensively in clinical trials. These trials require that ASCs are prepared using good manufacturing procedures (GMPs) and are safe for use in humans. The majority of clinical trials in which ASCs are expanded make use of fetal bovine serum (FBS). While FBS is used traditionally in the research setting for in vitro expansion, it does carry the risk of xenoimmunization and zoonotic transmission when used for expanding cells destined for therapeu...
25 CitationsSource
#1Chrisna Durandt (South African Medical Research Council)H-Index: 10
#2Fiona A. Van Vollenstee (South African Medical Research Council)H-Index: 4
Last. Michael S. Pepper (South African Medical Research Council)H-Index: 73
view all 8 authors...
The ability of mesenchymal stromal cells (MSCs) to differentiate into adipocytes provides a cellular model of human origin to study adipogenesis in vitro. One of the major challenges in studying adipogenesis is the lack of tools to identify and monitor the differentiation of various subpopulations within the heterogeneous pool of MSCs. Cluster of differentiation (CD)36 plays an important role in the formation of intracellular lipid droplets, a key characteristic of adipocyte differentiation/matu...
22 CitationsSource