Takayuki Kurokawa
Hokkaido University
AnatomySelf-healing hydrogelsBiomedical engineeringBrittlenessDeformation (engineering)PolyelectrolyteComposite materialMonomerNanotechnologyChemistryPolymer chemistryMaterials scienceIonic bondingSwellingPolyacrylamideCartilageDouble networkChemical engineeringFracture (geology)PolymerLamellar structureStress (mechanics)Toughness
211Publications
56H-index
10.4kCitations
Publications 213
Newest
#1Yun Zhou Guo (Hokkaido University)H-Index: 2
#2Tasuku Nakajima (Hokkaido University)H-Index: 35
Last. Jian Ping Gong (Hokkaido University)H-Index: 79
view all 9 authors...
Abstract null null The extreme mechanical strength of fibrous connective tissues in the human body, such as ligaments and tendons, has always been challenging for hydrogel scientists. Here, we created extremely strong, purely cellulose-based hydrogels (DCC-E gels). The fracture stress and Young’s modulus of the gels were improved to the level of an Achilles tendon even at their equilibrium swollen state. To make DCC-E gels, regenerated cellulose gels were first prepared with ethanol as the anti-...
Source
#1Wei Cui (Hokkaido University)H-Index: 7
#2Yiwan Huang (Hokkaido University)H-Index: 14
Last. Jian Ping Gong (Hokkaido University)H-Index: 79
view all 9 authors...
Summary null null The toughness of composite materials is size dependent below a critical load transfer length (lT). Fiber-reinforced viscoelastic polymers are uniquely suited to study the size-limited regime because the lT of these soft composites can be as high as several centimeters, in contrast to traditional composites where lT is extremely small, allowing a large window for macroscale characterization. In this work, we elucidate the parameters that influence the toughness of soft composite...
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#1Takayuki Nonoyama (Hokkaido University)H-Index: 21
#2Lei Wang (Hokkaido University)H-Index: 19
Last. Jian Ping Gong (Hokkaido University)H-Index: 79
view all 8 authors...
Source
#1Ya Nan Ye (Hokkaido University)H-Index: 6
#2Anamul Haque (Hokkaido University)H-Index: 2
Last. Jian Ping Gong (Hokkaido University)H-Index: 79
view all 6 authors...
1 CitationsSource
#1Kazuyoshi Yamazaki (Hokkaido University)H-Index: 9
#2Toshiya Osanai (Hokkaido University)H-Index: 14
Last. Jian Ping Gong (Hokkaido University)H-Index: 79
view all 13 authors...
The double network (DN) gel is a rigid, tough, and safe hydrogel; however, like all hydrogels and existing particle embolization materials composed of a polymer, they lack X-ray visibility. Thus, it is not possible to locate the embolization material in the body. In this study, we successfully developed an X-ray-visible embolization material, a tough DN gel incorporated with biocompatible heavy metal powder. The DN gel particles, composed of poly(N,N'-dimethylacrylamide) and poly(2-acrylamido-2-...
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#1Yong Zheng (Hokkaido University)H-Index: 1
#2Ryuji Kiyama (Hokkaido University)H-Index: 6
Last. Jian Ping Gong (Hokkaido University)H-Index: 79
view all 10 authors...
High modulus, toughness, and fatigue resistance are usually difficult to be obtained simultaneously in rubbery materials. Here, we report that by superimposing the nanophase separation structure in...
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#1Ya Nan Ye (Hokkaido University)H-Index: 6
#2Kunpeng Cui (Hokkaido University)H-Index: 19
Last. Jian Ping Gong (Hokkaido University)H-Index: 79
view all 9 authors...
Tough soft materials usually show strain softening and inelastic deformation. Here, we study the molecular mechanism of abnormally large nonsoftening, quasi-linear but inelastic deformation in tough hydrogels made of hyperconnective physical network and linear polymers as molecular glues to the network. The interplay of hyperconnectivity of network and effective load transfer by molecular glues prevents stress concentration, which is revealed by an affine deformation of the network to the bulk d...
2 CitationsSource
#1Xueyu Li (Hokkaido University)H-Index: 5
#2Kunpeng Cui (Hokkaido University)H-Index: 19
Last. Jian Ping Gong (Hokkaido University)H-Index: 79
view all 8 authors...
We investigate the fatigue resistance of chemically cross-linked polyampholyte hydrogels with a hierarchical structure due to phase separation and find that the details of the structure, as characterized by SAXS, control the mechanisms of crack propagation. When gels exhibit a strong phase contrast and a low cross-linking level, the stress singularity around the crack tip is gradually eliminated with increasing fatigue cycles and this suppresses crack growth, beneficial for high fatigue resistan...
1 CitationsSource
#1Tasuku NakajimaH-Index: 35
#2Ken Ichi Hoshino (Hokkaido University)
Last. Jian Ping GongH-Index: 79
view all 5 authors...
The equilibrium swelling degree of a highly swollen charged gel has been thought to be determined by the balance between its elastic pressure and ionic osmotic pressure. However, the full experimental verification of this balance has not previously been conducted. In this study, we verified the balance between the elastic pressure and ionic osmotic pressure of charged gels using purely experimental methods. We used tetra-PEG gels created using the molecular stent method (St-tetra-PEG gels) as th...
1 CitationsSource
#1Jun Suzuka (Hokkaido University)H-Index: 2
#2Masumi Tsuda (Hokkaido University)H-Index: 26
Last. Shinya Tanaka (Hokkaido University)H-Index: 72
view all 17 authors...
Cancer recurrence can arise owing to rare circulating cancer stem cells (CSCs) that are resistant to chemotherapies and radiotherapies. Here, we show that a double-network hydrogel can rapidly reprogramme differentiated cancer cells into CSCs. Spheroids expressing elevated levels of the stemness genes Sox2, Oct3/4 and Nanog formed within 24 h of seeding the gel with cells from any of six human cancer cell lines or with brain cancer cells resected from patients with glioblastoma. Human brain canc...
6 CitationsSource