Alan D. Waggoner
Washington University in St. Louis
Internal medicineRadiologyEndocrinologySurgeryDoppler effectCardiologySystoleHemodynamicsCardiac resynchronization therapyHeart failureRegurgitation (circulation)Body mass indexDoppler echocardiographyLeft atrialIn patientDiastoleMedicineEjection fractionStroke volumeBlood pressure
155Publications
52H-index
21.9kCitations
Publications 154
Newest
Background—Mitral regurgitation (MR) is associated with worse survival in those undergoing cardiac resynchronization therapy (CRT). Left ventricular (LV) lead position in CRT may ameliorate mechani...
9 CitationsSource
#1Sherif F. NaguehH-Index: 84
#2Otto A. Smiseth (University of Oslo)H-Index: 70
Last. Alan D. Waggoner (WashU: Washington University in St. Louis)H-Index: 52
view all 14 authors...
Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography : An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging
2,741 CitationsSource
#1Sophia Airhart (WashU: Washington University in St. Louis)H-Index: 6
#2W. Todd Cade (WashU: Washington University in St. Louis)H-Index: 22
Last. Linda R. Peterson (WashU: Washington University in St. Louis)H-Index: 31
view all 18 authors...
Context: Excessive cardiac long-chain fatty acid (LCFA) metabolism/storage causes cardiomyopathy in animal models of type 2 diabetes. Medium-chain fatty acids (MCFAs) are absorbed and oxidized efficiently. Data in animal models of diabetes suggest MCFAs may benefit the heart. Objective: Our objective was to test the effects of an MCFA-rich diet vs an LCFA-rich diet on plasma lipids, cardiac steatosis, and function in patients with type 2 diabetes. Design: This was a double-blind, randomized, 2-w...
21 CitationsSource
#1Alan D. Waggoner (WashU: Washington University in St. Louis)H-Index: 52
#2J. Geoffrey Stevenson (UW: University of Washington)H-Index: 20
mance of sonographers involved in the process of laboratory accreditation, and it uses a measure of performance based on independent review of case studies. An important aspect of Bremer’s study is that it included large numbers of credentialed and noncredentialed sonographers. It builds also on a recent publication by Nagueh et al. 2 that used the IAC database to determine factors associated with success or failure in achieving laboratory accreditation. Although the results of these two studies...
1 CitationsSource
#1Linda R. Peterson (WashU: Washington University in St. Louis)H-Index: 31
#2Pilar Herrero (WashU: Washington University in St. Louis)H-Index: 59
Last. Robert J. Gropler (WashU: Washington University in St. Louis)H-Index: 42
view all 13 authors...
Type 2 diabetes, obesity, and sex difference affect myocardial glucose uptake and utilization. However, their effect on the intramyocellular fate of glucose in humans has been unknown. How the heart uses glucose is important, because it affects energy production and oxygen efficiency, which in turn affect heart function and adaptability. We hypothesized that type 2 diabetes, sex difference, and obesity affect myocardial glucose oxidation, glycolysis, and glycogen production. In a first-in-human ...
22 CitationsSource
#1W. Todd Cade (WashU: Washington University in St. Louis)H-Index: 22
#2Dominic N. Reeds (WashU: Washington University in St. Louis)H-Index: 28
Last. Kevin E. Yarasheski (WashU: Washington University in St. Louis)H-Index: 67
view all 11 authors...
AbstractBackground: Individuals with HIV infection and peripheral metabolic complications have impaired basal myocardial insulin sensitivity that is related to left ventricular (LV) diastolic dysfunction. It is unknown whether interventions shown to be effective in improving peripheral insulin sensitivity can improve basal myocardial insulin sensitivity and diastolic function in people with HIV and peripheral metabolic complications. Objective: In a pilot study, we evaluated whether the peroxiso...
10 CitationsSource
#1William Todd Cade (WashU: Washington University in St. Louis)H-Index: 7
#2Edgar T. Overton (WashU: Washington University in St. Louis)H-Index: 33
Last. Kevin E. Yarasheski (WashU: Washington University in St. Louis)H-Index: 67
view all 11 authors...
Abstract Our objective was to determine if the presence of metabolic complications (MC) conveyed an additional risk for left ventricular (LV) dysfunction in people with HIV. HIV+ and HIV− men and women were categorized into four groups: (1) HIV+ with MC (43±7 years, n=64), (2) HIV+ without MC (42±7 years, n=59), (3) HIV− with MC (44±8 years, n=37), or (4) HIV− controls without MC (42±8 years, n=41). All participants underwent two-dimensional (2-D), Doppler, and tissue Doppler echocardiography. O...
3 CitationsSource
#1W. Todd Cade (WashU: Washington University in St. Louis)H-Index: 22
#2Carolyn T. Spencer (ECU: East Carolina University)H-Index: 14
Last. Linda R. Peterson (WashU: Washington University in St. Louis)H-Index: 31
view all 9 authors...
Background Barth syndrome (BTHS) is a rare X-linked disorder that is characterized by mitochondrial abnormalities, infantile or childhood onset of cardioskeletal myopathy, and high mortality rates. It is currently unknown if BTHS related mitochondrial dysfunction results in substrate metabolism abnormalities and thereby contributes to cardioskeletal myopathy in patients with BTHS.
31 CitationsSource
#1W. Todd Cade (WashU: Washington University in St. Louis)H-Index: 22
#2Alan D. Waggoner (WashU: Washington University in St. Louis)H-Index: 52
Last. E. Turner Overton (UAB: University of Alabama at Birmingham)H-Index: 22
view all 6 authors...
Abnormalities in left ventricular (LV) function are well-described in vertically-infected HIV-positive children [1-4]. Although antiretroviral therapy (ART) is effective in preventing the vertical transmission of HIV during pregnancy and parturition, HIV-negative children exposed to ART in utero may have depressed LV contractility, lower LV mass and resting tachycardia [4-6]. Subclinical LV dysfunction in HIV-negative children born to HIV+ women and exposed to ART may be clinically relevant give...
21 CitationsSource
#1Alan Cheng (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 38
#2Michael R. Gold (MUSC: Medical University of South Carolina)H-Index: 62
Last. Kenneth A. Ellenbogen (VCU: Virginia Commonwealth University)H-Index: 77
view all 8 authors...
Background Recent studies demonstrate that women may respond more favorably to cardiac resynchronization therapy (CRT) than do men. The mechanisms remain unclear. Objectives To describe the effects of gender on response to CRT and to explore potential mechanisms behind these differences. Methods Data for 846 patients from the SMART-AV trial were used to evaluate the mechanisms behind the effects of gender on CRT response. Atrioventricular optimization (AVO) was performed via SmartDelay or echoca...
36 CitationsSource