Ingo Nolte
University of Veterinary Medicine Vienna
GeneAnatomyCancerInternal medicineBiomedical engineeringSurgeryPathologyMolecular biologyChemistryMaterials scienceImmunologyLymphomaCATSOrthodonticsCancer researchGeneticsMedicineCell cultureBiologyGastroenterology
357Publications
32H-index
4,455Citations
Publications 361
Newest
#1F. Weiner (University of Veterinary Medicine Vienna)
#2Jan Torben Schille (University of Veterinary Medicine Vienna)H-Index: 2
Last. Ingo Nolte (University of Veterinary Medicine Vienna)H-Index: 32
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BACKGROUND The aminoisoquinoline FX-9 shows pro-apoptotic and antimitotic effects against lymphoblastic leukemia cells and prostate adenocarcinoma cells. In contrast, decreased cytotoxic effects against non-neoplastic blood cells, chondrocytes, and fibroblasts were observed. However, the actual FX-9 molecular mode of action is currently not fully understood. METHODS In this study, microarray gene expression analysis comparing FX-9 exposed and unexposed prostate cancer cells (PC-3 representing ca...
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#1Katharina Klose (University of Veterinary Medicine Vienna)
#2Eva-Maria Packeiser (University of Veterinary Medicine Vienna)H-Index: 1
Last. Ingo Nolte (University of Veterinary Medicine Vienna)H-Index: 32
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An important approach in tumor therapy is combining substances with different action mechanisms aiming to enhance the antineoplastic effect, decrease the therapeutic dosage, and avoid resistance mechanisms. Moreover, evaluating compounds already approved for the treatment of non-neoplastic diseases is promising for new antineoplastic therapies. Sodium dichloroacetate (DCA) reactivates oxidative phosphorylation in the cancer cell mitochondria, reducing apoptosis resistance in cancer cells. Furthe...
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#1Stephanie Klein (University of Veterinary Medicine Vienna)H-Index: 4
#2Ingo Nolte (University of Veterinary Medicine Vienna)H-Index: 32
Last. Jan-Peter Bach (University of Veterinary Medicine Vienna)H-Index: 3
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Background null Pimobendan is a widely used medication for the treatment of dogs with congestive heart failure (CHF) and preclinical degenerative mitral valve disease (DMVD) with cardiomegaly. The benefit of a treatment in dogs with preclinical DMVD but without cardiomegaly has not yet been elucidated. Some positive effects concerning life quality and a decrease in cardiac biomarkers could be verified. This study aimed to further investigate these results using a placebo-controlled double-blinde...
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#1Franziska Weiner (University of Veterinary Medicine Vienna)
#2Jan Torben Schille (University of Veterinary Medicine Vienna)H-Index: 2
Last. Ingo Nolte (University of Veterinary Medicine Vienna)H-Index: 32
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The isoquinolinamine FX-9 is a novel potential chemotherapeutic agent showing antiproliferative effects against hematologic and prostate cancer cell lines such as B- and T-acute lymphoblastic leukemia and prostate cancer (PC) of different species. Interestingly, FX-9 shows no hemolytic activity and low toxicity in benign adherent cells. The detailed FX-9 molecular mode of action is currently not fully understood. But application on neoplastic cells induces pro-apoptotic and antimitotic effects. ...
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Soluble Fms-like tyrosine kinase (sFlt-1/sVEGFR1) is a natural occurring antagonist of vascular endothelial growth factor (VEGF). Despite being a secreted, soluble protein lacking cytoplasmic and transmembrane domains, sFlt-1 can act locally and be protective against excessive microenvironmental VEGF concentration, or exert autocrine functions independently of VEGF. Circulating sFlt-1 may indiscriminately affect endothelial function and the microvasculature on distant target organs. The clinical...
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#1Maray WillenH-Index: 1
#2Malin LorkeH-Index: 1
Last. Ingo NolteH-Index: 32
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OBJECTIVE Aim was to establish an individually adapted endurance test for dogs on a treadmill, which takes the individual's physical condition into account. To check the applicability of the test, two age groups of clinically healthy beagles were examined. METHODS A total of 10 clinically healthy Beagles were enrolled and divided in a younger (1-3 years, n = 5) and older group (> 8 years, n = 5). The individual comfort gait speed of each dog was determined on a treadmill with integrated force pl...
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#1F. Weiner (University of Veterinary Medicine Hanover)
#2J. T. Schille (University of Veterinary Medicine Hanover)
Last. Ingo Nolte (University of Veterinary Medicine Hanover)H-Index: 32
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#2Ingo NolteH-Index: 32
Last. Jan-Peter BachH-Index: 3
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Objective Chronic gastrointestinal diseases in dogs are common and often require intensive diagnostic work-up and lifelong therapy. In this study, a survey of owners of affected dogs was conducted in parallel with a retrospective case analysis from the clinic’s documentation system. Material and methods The records of dogs with gastrointestinal symptomatology and exclusion of an extraintestinal cause, presented from January 2011 to October 2018, were acquired from the clinic’s case system and an...
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#1K. Klose (University of Veterinary Medicine Hanover)
#2E.-M. Packeiser (University of Veterinary Medicine Hanover)
Last. Ingo Nolte (University of Veterinary Medicine Hanover)H-Index: 32
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#1S. Klein (University of Veterinary Medicine Hanover)
#2Ingo Nolte (University of Veterinary Medicine Hanover)H-Index: 32
Last. Jan-Peter Bach (University of Veterinary Medicine Hanover)H-Index: 3
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