Maria Thor
Memorial Sloan Kettering Cancer Center
Internal medicineRadiologyUrologySurgeryMagnetic resonance imagingOncologyArtificial intelligenceImage registrationRadiation treatment planningProstateLung cancerHead and neck cancerTrismusProstate cancerRectumToxicityNuclear medicineComputer scienceRadiation therapyMedicineSegmentation
131Publications
16H-index
782Citations
Publications 133
Newest
#1Laura Cella (National Research Council)H-Index: 25
#2Serena Monti (National Research Council)H-Index: 14
Last. Giuseppe Palma (National Research Council)H-Index: 14
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In this study, we investigated the prognostic factors for radiation-induced dyspnea after hypo-fractionated radiation therapy (RT) in 106 patients treated with Stereotactic Body RT for Non-Small-Cell Lung Cancer (NSCLC). The median prescription dose was 50 Gy (range: 40–54 Gy), delivered in a median of four fractions (range: 3–12). Dyspnea within six months after SBRT was scored according to CTCAE v.4.0. Biologically Effective Dose (α/β = 3 Gy) volume histograms for lungs and heart were extracte...
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#1Maria Thor (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 16
#2Aditi Iyer (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 4
Last. Sharif Elguindi (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 4
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1 CitationsSource
#1Quincey LaPlant (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 6
#2Maria Thor (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 16
Last. Daphna Y. Gelblum (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 18
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#1Maria Thor (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 16
#2Aditya Apte (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 19
Last. Joseph O. Deasy (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 63
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Purpose Contouring inconsistencies are known but understudied in clinical radiation therapy trials. We applied auto-contouring to the Radiation Therapy Oncology Group (RTOG) 0617 dose escalation trial data. We hypothesized that the trial heart doses were higher than reported due to inconsistent and insufficient heart segmentation. We tested our hypothesis by comparing doses between deep-learning (DL) segmented hearts and trial hearts. Methods and Materials The RTOG 0617 data were downloaded from...
3 CitationsSource
#1Ellen Yorke (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 62
#2Maria Thor (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 16
Last. Andrew Jackson (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 59
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Based on an analysis of published literature, our department recently lowered the preferred mean esophagus dose (MED) constraint for conventionally fractionated (2 Gy/fraction in approximately 30 fractions) treatment of locally advanced non-small cell lung cancer (LA-NSCLC) with the goal of reducing the incidence of symptomatic acute esophagitis (AE). The goal of the change was to encourage treatment planners to achieve a MED close to 21 Gy while still permitting MED to go up to the previous gui...
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#1Margaret Montovano (RU: Rutgers University)H-Index: 2
#2Minsi Zhang (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 2
Last. Andrew Jackson (RU: Rutgers University)
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Abstract Purpose/Objective(s) To determine incidence and predictors of gastric bleeding after chemoradiation for esophageal or GE junction cancer. Materials/Methods We reviewed patients receiving chemoradiation to at least 41.4Gy for localized esophageal cancer whose fields included the stomach, and who did not undergo surgical resection. The primary endpoint was grade ≥3 gastric hemorrhage (GB3+). Comprehensive stomach dose-volume parameters were collected and stomach dose-volume histograms (DV...
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#1Sadegh R Alam (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 3
#2Pengpeng Zhang (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 16
Last. Maria Thor (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 16
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Abstract Purpose Acute esophagitis (AE) is a common dose-limiting toxicity in radiotherapy (RT) of locally advanced non-small cell lung cancer (LA-NSCLC). We developed an early AE prediction model from weekly accumulated esophagus dose and its associated local volumetric change. Methods 51 LA-NSCLC patients were treated via IMRT to 60Gy in 2 Gy-fractions with concurrent chemotherapy and had weekly cone-beam CTs (CBCTs). Twenty-eight patients (55%) developed ≥grade2 AE (≥AE2) at a median of 4 wee...
3 CitationsSource
#1Narek Shaverdian (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 16
#2J. Beattie (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 1
Last. Daniel R. Gomez (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 17
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Background Immune checkpoint inhibitors (ICIs) and thoracic radiotherapy are increasingly used to treat advanced cancers. Despite data indicating exaggerated radiation toxicities in patients with autoimmune disease, the safety of thoracic radiotherapy in patients with prior ICI-associated immune-related adverse events (irAEs) is undefined. Patients and methods Patients treated from 2014 to 2020 with ICIs were queried for receipt of corticosteroids and radiotherapy. Patients who received thoracic...
2 CitationsSource
#1Chuang WangH-Index: 2
#2Sadegh R AlamH-Index: 3
Last. Pengpeng ZhangH-Index: 16
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Acute esophagitis (AE) occurs among a significant number of patients with locally advanced lung cancer treated with radiotherapy. Early prediction of AE, indicated by esophageal wall expansion, is critical, as it can facilitate the redesign of treatment plans to reduce radiation-induced esophageal toxicity in an adaptive radiotherapy (ART) workflow. We have developed a novel machine learning framework to predict the patient-specific spatial presentation of the esophagus in the weeks following tr...
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