Anusha Ashokan
Amrita Vishwa Vidyapeetham
CytotoxicityCancerBiophysicsNanotoxicologyBiomedical engineeringMolecular imagingMagnetic resonance imagingNanoparticleRegeneration (biology)NanotechnologyChemistryMaterials scienceImmunologyIn vivoBiocompatibilityRadiofrequency ablationTemozolomideImmunotherapyBiodistributionGliomaBioactive glassBone tissueMacrophageDrug deliveryNano-Cancer immunotherapyPreclinical imagingPlatelet activationComputer scienceNear-infrared spectroscopyCancer researchCalciumManganeseGadoliniumFluorescence-lifetime imaging microscopyDopingMedicineImmune systemScaffoldNanofiberFluorescenceCancer cell
24Publications
8H-index
518Citations
Publications 23
Newest
#1Badrinathan Sridharan (Amrita Vishwa Vidyapeetham)H-Index: 1
#2Naveen Devarajan (Amrita Vishwa Vidyapeetham)
Last. Manzoor Koyakutty (Amrita Vishwa Vidyapeetham)H-Index: 24
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Early detection of liver tumors and cirrhotic lesions by magnetic resonance imaging (MRI) remains a great challenge. Here, we report a biomineral nanocontrast agent based on iron-doped nanocalcium ...
1 CitationsSource
#1Nikhil VaderaH-Index: 2
#2Anusha AshokanH-Index: 8
Last. Manzoor KoyakuttyH-Index: 24
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#1Ida M. Anna (Amrita Vishwa Vidyapeetham)H-Index: 2
#2Binulal N. Sathy (Amrita Vishwa Vidyapeetham)H-Index: 13
Last. Manzoor Koyakutty (Amrita Vishwa Vidyapeetham)H-Index: 24
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In vivo tracking of transplanted stem cells to monitor their migration, biodistribution, and engraftment in the host tissue is important for assessing the efficacy of stem cell therapeutics. Here, we report a biomineral nanocontrast agent, iron doped calcium phosphate nanoparticles (nCP:Fe), for the in vivo tracking of stem cells in brain using magnetic resonance imaging (MRI). We have synthesized ∼100 nm sized nCP nanoparticles doped with 9.81 wt % Fe3+. In vitro studies using mesenchymal stem ...
3 CitationsSource
#1Anusha Ashokan (AIMS: Amrita Institute of Medical Sciences and Research Centre)H-Index: 8
#2Genekehal S. Gowd (AIMS: Amrita Institute of Medical Sciences and Research Centre)H-Index: 4
Last. Manzoor Koyakutty (AIMS: Amrita Institute of Medical Sciences and Research Centre)H-Index: 24
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#1K.M. Sajesh (AIMS: Amrita Institute of Medical Sciences and Research Centre)H-Index: 5
#2Anusha Ashokan (AIMS: Amrita Institute of Medical Sciences and Research Centre)H-Index: 8
Last. Manzoor Koyakutty (AIMS: Amrita Institute of Medical Sciences and Research Centre)H-Index: 24
view all 7 authors...
Abstract We report an osteoconducting magnetic 3D scaffold using Fe2+ doped nano-hydroxyapatite-Alginate-Gelatin (AGHFe1) for Magnetic Resonance Imaging based non-invasive monitoring of bone tissue regeneration. In rat cranial defect model, the scaffold facilitated non-invasive monitoring of cell migration, inflammatory response and matrix deposition by unique changes in transverse relaxation time (T2). Cell infiltration resulted in a considerable increase in T2 from ~37 to ~62 ms, which gradual...
6 CitationsSource
Nanoparticle platforms can be engineered to deliver immune-stimulatory molecules to specific immune cell populations, thereby evoke desired response. Here, we present a novel biomineral nanoparticle system for macrophage specific delivery of bisphosphonate molecules to evoke activation of γδ T-cells for cancer immunotherapy. Generally, γδ T-cells therapy is implemented either by ex vivo expansion followed by adoptive transfer or by in vivo activation using intravenous injection of bisphosphonate...
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In the emerging era of artificial intelligence mediated immune response analysis, post- imunotherapeutic interventions, monitoring of large pool of data related to different types of immune cells is a critical requirement. Several gold standard methodologies such as flow cytometry, cytoTOF, ELISPOT and other immune-imaging techniques are routinely used for quantifying the phenotypic behavior of immune cells. These techniques involve the use of antibodies for specifically labeling each cell types...
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Nanoparticle-based immunotherapeutic platforms are emerging as radically different, biocompatible alternatives for viral-vectors. Liposomal nanoplexes already showed potential for clinical translation of mutanome specific personalized cancer-vaccines in human. Here, we report a novel nanoparticle platform technology for neoantigen specific mRNA (neo-mRNA) vaccine delivery and demonstrated its potential for evoking T-cell mediated immune response against drug/radiation resistant glioma cells. Gli...
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#1Anusha Ashokan (CUSAT: Cochin University of Science and Technology)H-Index: 8
#2Vijay Harish Somasundaram (Amrita Vishwa Vidyapeetham)H-Index: 7
Last. Manzoor Koyakutty (Amrita Vishwa Vidyapeetham)H-Index: 24
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Theranostic nanoparticles based on biocompatible mineral compositions can significantly improve the translational potential of image guided cancer nano-therapy. Here, we report development of a single-phase calcium phosphate biomineral nanoparticle (nCP) with dual-mode magnetic resonance contrast (T1-T2) together with radiofrequency (RF) mediated thermal response suitable for image-guided RF ablation of cancer. The nanoparticles (NP) are engineered to provide dual MR contrast by an optimized dop...
14 CitationsSource