Piul S. Rabbani
New York University
Wnt signaling pathwayPathologyRegeneration (biology)Mesenchymal stem cellImmunologyEx vivoOxidative stressKEAP1Hair follicleMelanocyteWound healingStem cellTransplantationReactive oxygen speciesCancer researchDiabetes mellitusMedicineBiologyCell biologyPharmacology
50Publications
12H-index
869Citations
Publications 50
Newest
#1Bibi S Subhan (NYU: New York University)H-Index: 1
#2Jennifer Kwong (NYU: New York University)H-Index: 1
Last. Piul S. Rabbani (NYU: New York University)H-Index: 12
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BACKGROUND Cutaneous wounds in patients with diabetes exhibit impaired healing due to physiological impediments and conventional care options are severely limited. Multipotent stromal cells (MSCs) have been touted as a powerful new therapy for diabetic tissue repair owing to their trophic activity and low immunogenicity. However, variations in sources and access are limiting factors for broader adaptation and study of MSC-based therapies. Amniotic fluid presents a relatively unexplored source of...
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#2Melat Worku Tiruneh (RU: Rutgers University)H-Index: 1
Last. Daniel J. CeradiniH-Index: 24
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Unveiling the molecular mechanisms underlying tissue regeneration provides new opportunities to develop treatments for diabetic ulcers and other chronic skin lesions. Here, we show that Ccl2 secretion by epidermal keratinocytes is directly orchestrated by Nrf2, a prominent transcriptional regulator of tissue regeneration that is activated early after cutaneous injury. Through a unique feedback mechanism, we find that Ccl2 from epidermal keratinocytes not only drives chemotaxis of macrophages int...
2 CitationsSource
Chronic venous insufficiency (CVI) stems from venous hypertension, extravasation of blood, and iron-rich skin deposits. The latter is central to ulcer development through generating reactive oxygen species (ROS) that drive persistent local inflammation and the development of lipodermatosclerosis. The ability to study CVI cutaneous inflammation is fundamental to advancing therapies. To address this end, a novel protocol was adapted to investigate cutaneous wound healing in iron-induced inflammati...
1 CitationsSource
#1Joseph KuhnH-Index: 1
#2Absara HassanH-Index: 1
Last. Piul S. RabbaniH-Index: 12
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Exosomes, nanosized extracellular vesicles, may be key to translating multipotent stromal cell (MSC) therapy to the bedside. We previously found that nuclear factor erythroid 2-related factor 2 (Nrf2) regulates MSC promotion of tissue repair in diabetes. Here, we explore a novel role of Nrf2 in exosome biogenesis and investigate whether exosome treatment recapitulates the effects MSCs have on wound healing in mice with type 2 diabetes. Exosomes were harvested by differential ultracentrifugation ...
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: Despite promising short- and long-term results to date in vascularized composite allotransplantation (VCA), acute rejection remains the most common major complication in recipients. Currently, diagnosis of acute rejection relies on clinical inspection correlated with histopathological analysis. However, disagreement exists regarding the value of full-thickness skin and mucosal biopsies and histopathology remains semiquantitative, subject to sampling bias, and prone to intra- and inter-observer...
1 CitationsSource
#1Joseph KuhnH-Index: 1
#2Joshua A. DavidH-Index: 10
Last. Daniel J. CeradiniH-Index: 24
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Imbalance in the production of reactive oxygen species predisposes diabetic patients to delayed wound healing, but treatments that directly address this imbalance are lacking. Nrf2 and its natural inhibitor, Keap1, maintain redox homeostasis. However, the exact contribution Nrf2 makes to healing is unclear. Here we demonstrate that Nrf2 loss of function in discreet layers of the epidermis corresponds with substantial oxidative stress burdens and a concomitant delay in healing human tissue. Compa...
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