Müjdat Zeybel
Koç University
GeneInternal medicineSurgeryPathologyGene expression profilingDNA methylationImmunologyBiopsyLiver diseaseCirrhosisAlcoholic liver diseaseMupirocinEndoscopyFatty liverStaphylococcus aureusFibrosisCatheterContinuous ambulatory peritoneal dialysisLiver fibrosisIn patientEpigeneticsRefluxCancer researchGeneticsHistoneComputational biologyMedicineChromatinBiologyGastroenterologyCell biology
Publications 42
#1Genco Gençdal (Koç University)
#2Müjdat Zeybel (Koç University)H-Index: 11
Last. Cihan Yurdaydin (Koç University)H-Index: 4
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#1Ecem Fatma Karaman (Istanbul University)H-Index: 6
#2Müjdat Zeybel (Koç University)H-Index: 11
Last. Sibel Ozden (Istanbul University)H-Index: 15
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Abstract Zearalenone, produced by various Fusarium species, is a non-steroidal estrogenic mycotoxin that contaminates cereals, resulting in adverse effects on human health. We investigated the effects of zearalenone and its metabolite alpha zearalenol on epigenetic modifications and its relationship with metabolic pathways in human hepatocellular carcinoma cells following 24 h of exposure. Zearalenone and alpha zearalenol at the concentrations of 1, 10 and 50 µM significantly increased global le...
7 CitationsSource
#1Tan Attila (Koç University)H-Index: 3
#2Müjdat Zeybel (Koç University)H-Index: 11
Last. Zeynel MunganH-Index: 21
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INTRODUCTION: Socioeconomic factors play an important role in the prevalence of Helicobacter pylori (HP) infection. The aim of this study is to investigate HP prevalence among symptomatic patients in the upper socioeconomic segment of the population undergoing gastroscopy in an endemic urban region. METHODOLOGY: Over a 12-month period, data were collected from the first consecutive 1000 patients (500 from university hospital, 500 from community hospital) who had gastroscopy and HP evaluation. RE...
2 CitationsSource
#1Burge Ulukan (Koç University)H-Index: 1
#2Yasemin Sila Ozkaya (Koç University)H-Index: 1
Last. Müjdat Zeybel (Koç University)H-Index: 11
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Fibroblasts have a central role in tissue fibrosis and fibrotic diseases. Fibroblast activation is regulated by several mechanisms including epigenetic modifications; histone modifications, DNA methylation and non-coding RNAs. Although research has significantly contributed to our basic understanding of fibrotic diseases over the last decade, cooperative activity of epigenetic mechanisms demonstrates the complexity of fibrogenesis. This review will summarise the latest epigenetic advances in fib...
2 CitationsSource
#1Murat Akyildiz (Koç University)H-Index: 3
#2Emel Ahıskalı (Koç University)H-Index: 1
Last. Cihan Yurdaydin (Koç University)H-Index: 4
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3 CitationsSource
#1Adil MardinogluH-Index: 39
#2Dilek Ural (Koç University)H-Index: 21
Last. Jan Borén (Sahlgrenska University Hospital)H-Index: 90
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Non-alcoholic fatty liver disease (NAFLD) is caused by the imbalance between lipid deposition and lipid removal from the liver, and its global prevalence continues to increase dramatically. NAFLD encompasses a spectrum of pathological conditions including simple steatosis and non-alcoholic steatohepatitis (NASH), which can progress to cirrhosis and liver cancer. Even though there is a multi-disciplinary effort for development of a treatment strategy for NAFLD, there is not an approved effective ...
19 CitationsSource
#1Berna Morova (Koç University)H-Index: 3
#2Nima Bavili (Koç University)H-Index: 3
Last. Alper Kiraz (Koç University)H-Index: 27
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Fabrication and characterization of flexible optical fiber bundles (FBs) with in-house synthesized high-index and low-index thermally matched glasses are presented. The FBs composed of around 15000 single-core fibers with pixel sizes between 1.1 and 10 μm are fabricated using the stack-and-draw technique from sets of thermally matched zirconium-silicate ZR3, borosilicate SK222, sodium-silicate K209, and F2 glasses. With high refractive index contrast pair of glasses ZR3/SK222 and K209/F2, FBs wi...
7 CitationsSource
#1Burge UlukanH-Index: 1
#2Buket YiğitH-Index: 2
Last. Müjdat ZeybelH-Index: 11
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#1Buket Yiğit (Koç University)H-Index: 2
#2Marie Boyle (Newcastle University)H-Index: 5
Last. Jelena Mann (Newcastle University)H-Index: 39
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We recently reported dynamic epigenetic markers of fibrosis detectable in patients’ plasma that may have utility in non-invasive diagnosis and staging of fibrosis in patients with chronic liver disease.1 Specifically, we uncovered DNA methylation markers at the human PPARγ promoter detectable in circulating cell-free DNA (ccfDNA) that display differential methylation densities. Remarkably, PPARγ hypermethylation correlated with progression to cirrhosis in alcoholic liver disease (ALD) and with s...
16 CitationsSource
2 CitationsSource