Haruko Watanabe-Takano
Chiba University
Gene silencingActinInternal medicineEndocrinologyGenetically modified mouseMolecular biologyReceptorGene knockdownChemistryInterleukin 4ImmunologyHead and neck squamous-cell carcinomaBCL6PeriosteumOsteoblastCytokineLong boneCell cycleBone growthActin cytoskeletonCancer researchCarcinogenesisMAPK/ERK pathwaySignal transductionHormoneMedicineFibroblast growth factorTranscription factorBiologyImmune systemCell biology
Publications 22
#1Takaya Handa (Kyoto University)H-Index: 1
#2Keita P. Mori (Kyoto University)H-Index: 12
Last. Naoki MochizukiH-Index: 67
view all 13 authors...
Natriuretic peptides exert multiple effects by binding to natriuretic peptide receptors (NPRs). Osteocrin (OSTN) binds with high affinity to NPR-C, a clearance receptor for natriuretic peptides, and inhibits degradation of natriuretic peptides and consequently enhances guanylyl cyclase-A (GC-A/NPR1) signaling. However, the roles of OSTN in the kidney have not been well clarified. Adriamycin (ADR) nephropathy in wild-type mice showed albuminuria, glomerular basement membrane changes, increased po...
#1Yoshihiko Nishiguchi (Kumamoto University)H-Index: 2
#2Yusuke Hata (Kumamoto University)H-Index: 1
Last. Takashige Kuwabara (Kumamoto University)H-Index: 13
view all 17 authors...
Background null Osteocrin (OSTN), a bone-derived humoral factor, was reported to act on heart and bone by potentiating the natriuretic peptide (NP) system. Ostn gene polymorphisms have been associated with renal function decline, but its pathophysiological role in the kidney remains unclear. null Methods null The role of endogenous OSTN was investigated using systemic Ostn-knockout mice (KO). As a model for OSTN administration, liver-specific Ostn-overexpressing mice crossed with KO (KO-Tg) were...
#2Hiroki OchiH-Index: 19
Last. Kazuki Tainaka (Niigata University)H-Index: 16
view all 18 authors...
Summary null null Mechanical stimuli including loading after birth promote bone growth. However, little is known about how mechanical force triggers biochemical signals to regulate bone growth. Here, we identified a periosteal-osteoblast-derived secretory peptide, Osteocrin (OSTN), as a mechanotransducer involved in load-induced long bone growth. OSTN produced by periosteal osteoblasts regulates growth plate growth by enhancing C-type natriuretic peptide (CNP)-dependent proliferation and maturat...
#2Hiroki Ochi (Tokyo Medical and Dental University)H-Index: 19
Last. Naoki MochizukiH-Index: 67
view all 13 authors...
During development of long bones, two mechanistically distinct processes contribute to long- and short-axis growth. Endochondral ossification in the growth plate leads to the long-axis growth, while intramembranous ossification including apposition in the periosteum regulates the short axis growth. Here, we show that periosteal osteoblast-derived secretory peptide, Osteocrin (OSTN), promotes both types of long bone growth through potentiation of signaling by C-type natriuretic peptide (CNP), bec...
#1Takashi Ogasawara (Chiba University)H-Index: 5
#2Yuko Kohashi (Chiba University)H-Index: 1
Last. Masafumi Arima (Dokkyo Medical University)H-Index: 22
view all 16 authors...
Transcriptional repressor B-cell lymphoma 6 (Bcl6) appears to regulate TH2 immune responses in allergies, but its precise role is unclear. We previously reported that Bcl6 suppressed IL-4 production in naive CD4+ T cell-derived memory TH2 cells. To investigate Bcl6 function in allergic responses in naturally occurring memory phenotype CD4+ T (MPT) cells and their derived TH2 (MPTH2) cells, Bcl6-manipulated mice, highly conserved intron enhancer (hcIE)-deficient mice, and reporter mice for conser...
The heart is regarded as an endocrine organ as well as a pump for circulation, since atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) were discovered in cardiomyocytes to be secreted as hormones. Both ANP and BNP bind to their receptors expressed on remote organs, such as kidneys and blood vessels; therefore, the heart controls the circulation by pumping blood and by secreting endocrine peptides. Cardiomyocytes secrete other peptides besides natriuretic peptides. Although mos...
#1Yugo KanaiH-Index: 9
#2Akihiro YasodaH-Index: 28
Last. Nobuya InagakiH-Index: 82
view all 19 authors...
: Although peptides are safe and useful as therapeutics, they are often easily degraded or metabolized. Dampening the clearance system for peptide ligands is a promising strategy for increasing the efficacy of peptide therapies. Natriuretic peptide receptor B (NPR-B) and its naturally occurring ligand, C-type natriuretic peptide (CNP), are potent stimulators of endochondral bone growth, and activating the CNP/NPR-B system is expected to be a powerful strategy for treating impaired skeletal growt...
#1Takashi Ogasawara (Chiba University)H-Index: 5
#2Masahiko Hatano (Chiba University)H-Index: 39
Last. Masafumi Arima (Dokkyo Medical University)H-Index: 22
view all 20 authors...
Abstract Mice deficient in the transcriptional repressor B-cell CLL/lymphoma 6 (Bcl6) exhibit similar T helper 2 (TH2) immune responses as patients with allergic diseases. However, the molecular mechanisms underlying Bcl6-directed regulation of TH2 cytokine genes remain unclear. We identified multiple Bcl6/STAT binding sites (BSs) in TH2 cytokine gene loci. We found that Bcl6 is modestly associated with the BSs, and it had no significant effect on cytokine production in newly differentiated TH2 ...
#1Ayano ChibaH-Index: 7
Last. Naoki MochizukiH-Index: 67
view all 10 authors...
The heart is an endocrine organ, as cardiomyocytes (CMs) secrete natriuretic peptide (NP) hormones. Since the discovery of NPs, no other peptide hormones that affect remote organs have been identified from the heart. We identified osteocrin (Ostn) as an osteogenesis/chondrogenesis regulatory hormone secreted from CMs in zebrafish. ostn mutant larvae exhibit impaired membranous and chondral bone formation. The impaired bones were recovered by CM-specific overexpression of OSTN. We analyzed the pa...
#1Youichi Teratake (Chiba University)H-Index: 3
#2Chisa Kuga (Chiba University)H-Index: 1
Last. Masahiko HatanoH-Index: 39
view all 11 authors...
Cell proliferation and differentiation are coordinated during development. Chromosome status is monitored at the G1 and G2 cell cycle checkpoints to start DNA replication and cell division, respectively. Many factors that regulate cell cycle entry, arrest, or progression have been identified. Cyclins and cyclin-dependent kinases (CDKs) are key players of cell cycle regulation1,2. CDKs form complex with their cyclin partner. Cyclin/CDK complex regulates progression of the cell cycle by phosphoryl...
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