Barbara C. Vanderhyden
Ottawa Hospital Research Institute
CancerInternal medicineDownregulation and upregulationEndocrinologyPathologyOncologyCellMolecular biologyImmunologyIn vivoOocyteEstrogenOvaryOvarian cancerOvarian follicleCancer researchEpitheliumCarcinogenesisCell growthMedicineEpithelial–mesenchymal transitionBiologyCell biologyCancer cell
180Publications
48H-index
6,219Citations
Publications 134
Newest
#1Lauren E. Carter (Ottawa Hospital Research Institute)H-Index: 4
#2David P Cook (Ottawa Hospital Research Institute)H-Index: 7
Last. Barbara C. Vanderhyden (Ottawa Hospital Research Institute)H-Index: 9
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The ovarian surface epithelium (OSE) is a monolayer of epithelial cells surrounding the ovary that ruptures during each ovulation to allow release of the oocyte. This wound is quickly repaired, but mechanisms promoting repair are poorly understood. The contribution of tissue-resident stem cells in the homeostasis of several epithelial tissues is widely accepted, but their involvement in OSE is unclear. We show that traits associated with stem cells can be increased following exposure to the cyto...
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#1Maria Hurskainen (Ottawa Hospital Research Institute)H-Index: 1
#2Ivana Mižíková (Ottawa Hospital Research Institute)H-Index: 2
Last. Bernard Thébaud (Ottawa Hospital Research Institute)H-Index: 11
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During late lung development, alveolar and microvascular development is finalized to enable sufficient gas exchange. Impaired late lung development manifests as bronchopulmonary dysplasia (BPD) in preterm infants. Single-cell RNA sequencing (scRNA-seq) allows for assessment of complex cellular dynamics during biological processes, such as development. Here, we use MULTI-seq to generate scRNA-seq profiles of over 66,000 cells from 36 mice during normal or impaired lung development secondary to hy...
1 CitationsSource
#1David P Cook (U of O: University of Ottawa)H-Index: 7
Last. Barbara C. VanderhydenH-Index: 48
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Epithelial-mesenchymal plasticity (EMP) contributes to tumour progression, promoting therapy resistance and immune cell evasion. Definitive molecular features of this plasticity have largely remained elusive due to the limited scale of most studies. Leveraging scRNA-seq data from 160 tumours spanning 8 different cancer types, we identify expression patterns associated with intratumoural EMP. Integrative analysis of these programs confirmed a high degree of diversity among tumours. These diverse ...
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#1Sabrina Robichaud (U of O: University of Ottawa)H-Index: 2
#2Garrett D Fairman (U of O: University of Ottawa)H-Index: 2
Last. Mireille Ouimet (U of O: University of Ottawa)H-Index: 22
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Macrophage autophagy is a highly anti-atherogenic process that promotes the catabolism of cytosolic lipid droplets (LDs) to maintain cellular lipid homeostasis. Selective autophagy relies on tags s...
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#1Maisa Alkailani (U of O: University of Ottawa)
#2Gareth Palidwor (Institute for Systems Biology)
Last. Derrick Gibbings (U of O: University of Ottawa)H-Index: 14
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It is challenging to identify the causes and consequences of retrotransposon expression in human disease due to the hundreds of active genomic copies and their poor conservation across species. We profiled genomic insertions of retrotransposons in ovarian cancer. In addition, in ovarian and breast cancer we analyzed RNAs exhibiting Bayesian correlation with retrotransposon RNA to identify causes and consequences of retrotransposon expression. This strategy finds divergent inflammatory responses ...
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#1David A. Landry (Ottawa Hospital Research Institute)
#2Het T. Vaishnav (Ottawa Hospital Research Institute)
Last. Barbara C. Vanderhyden (Ottawa Hospital Research Institute)H-Index: 48
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Ovarian aging is associated with significant changes in the structural organization of collagen, resulting in ovarian fibrosis. In many other tissues, fibrosis increases risks associated with tumorigenesis and metastasis. Thus, it is possible that ovarian fibrosis increases the risk of ovarian cancer by creating a microenvironment more permissive to tumor growth. In this research perspective, we review the impact of female reproduction on the development of ovarian fibrosis and the contributions...
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#1Denuja Karunakaran (U of O: University of Ottawa)H-Index: 15
#2Adam W. Turner (U of O: University of Ottawa)H-Index: 7
Last. Katey J. Rayner (U of O: University of Ottawa)H-Index: 39
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#1Denuja Karunakaran (U of O: University of Ottawa)H-Index: 15
#2Adam W. Turner (U of O: University of Ottawa)H-Index: 7
Last. Katey J. Rayner (U of O: University of Ottawa)H-Index: 39
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Obesity is a major public health burden worldwide and is characterized by chronic low-grade inflammation driven by the cooperation of the innate immune system and dysregulated metabolism in adipose tissue and other metabolic organs. Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a central regulator of inflammatory cell function that coordinates inflammation, apoptosis and necroptosis in response to inflammatory stimuli. Here we show that genetic polymorphisms near the human RI...
1 CitationsSource
#1Ivana MizikovaH-Index: 1
#2Maria HurskainenH-Index: 1
Last. Bernard Thébaud (Ottawa Hospital Research Institute)H-Index: 5
view all 12 authors...
The chronic lung disease bronchopulmonary dysplasia (BPD) is the most common complication in preterm infants. It is characterized by alveolar hypoplasia and dysmorphic vasculature. Changes in cellular composition and gene expression underlying the development of BPD are not fully understood. Here we created a detailed temporal map of normal and aberrant late lung development using single-cell RNA sequencing on lung cells from 36 mice at postnatal days (P) 3, 7 and 14. BPD was mimicked by exposur...
1 CitationsSource
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