Heiko Witt
Technische Universität München
GeneEndocrinologyGenotypePathologySingle-nucleotide polymorphismMolecular biologyAlleleImmunologyPancreatitisAcute pancreatitisPancreatic diseaseDiseasePRSS2TrypsinogenAllele frequencyMutationGeneticsMedicineBiologyGastroenterology
Publications 182
#1Katharina Seltsam (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 3
#1Katharina Seltsam (MLU: Martin Luther University of Halle-Wittenberg)
Last. Jonas Rosendahl (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 9
view all 13 authors...
Abstract Background /Objectives: A recent Genome-wide Association Study (GWAS) in alcoholic chronic pancreatitis (ACP) identified a novel association with the CTRB1-CTRB2 (chymotrypsinogen B1, B2) locus, linked to a 16.6 kb inversion that was confirmed in non-alcoholic chronic pancreatitis (NACP). Moreover, recent findings on the function of CTRB1 and CTRB2 suggest a protective role in pancreatitis development. The aim of the present study was to investigate the CTRB1-CTRB2 locus for rare geneti...
#1Tom Kaune (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 5
#2Claudia Ruffert (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 8
Last. Jonas Rosendahl (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 9
view all 33 authors...
Abstract Background The G-protein-coupled receptor Class C Group 6 Member A (GPRC6A) is activated by multiple ligands and is important for the regulation of calcium homeostasis. Extracellular calcium is capable to increase NLRP3 inflammasome activity of the innate immune system and deletion of this proinflammatory pathway mitigated pancreatitis severity in vivo. As such this pathway and the GPRC6A receptor is a reasonable candidate gene for pancreatitis. Here we investigated the prevalence of se...
#1J-Matthias Löhr (Karolinska University Hospital)H-Index: 10
#2Ulrich Beuers (UvA: University of Amsterdam)H-Index: 66
Last. Heiko Witt (TUM: Technische Universität München)H-Index: 40
view all 35 authors...
The overall objective of these guidelines is to provide evidence-based recommendations for the diagnosis and management of immunoglobulin G4 (IgG4)-related digestive disease in adults and children. IgG4-related digestive disease can be diagnosed only with a comprehensive work-up that includes histology, organ morphology at imaging, serology, search for other organ involvement, and response to glucocorticoid treatment. Indications for treatment are symptomatic patients with obstructive jaundice, ...
13 CitationsSource
#1Atsushi Masamune (Tohoku University)H-Index: 53
#2Hiroshi Kotani (LMB: Laboratory of Molecular Biology)H-Index: 2
Last. Tooru ShimosegawaH-Index: 69
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Abstract Background and Aims Changes in pancreatic calcium levels affect secretion and might be involved in development of chronic pancreatitis (CP). We investigated the association of CP with the transient receptor potential cation channel subfamily V member 6 gene (TRPV6), which encodes a Ca2+-selective ion channel, in an international cohort of patients and in mice. Methods We performed whole-exome sequencing DNA from a patient with idiopathic CP and from his parents, who did not have CP. We ...
21 CitationsSource
#1Alessandro De Grandi (University of Lübeck)H-Index: 13
#2Maria Franzini (UniPi: University of Pisa)H-Index: 20
Last. Andreas R. Janecke (Innsbruck Medical University)H-Index: 49
view all 20 authors...
2 CitationsSource
#2A.M. Drewes (AAU: Aalborg University)
Last. Péter HegyiH-Index: 39
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#1Emmanuelle Masson (French Institute of Health and Medical Research)H-Index: 18
#2Wen-Bin Zou ('SMMU': Second Military Medical University)H-Index: 13
Last. C Ferec ('SMMU': Second Military Medical University)H-Index: 1
view all 20 authors...
Chronic pancreatitis is a complex disease that involves many factors, both genetic and environmental. Over the past two decades, molecular genetic analysis of five genes that are highly expressed in human pancreatic acinar cells, namely PRSS1, PRSS2, SPINK1, CTRC and CTRB1/CTRB2 , has established that a trypsin-dependent pathway plays a key role in the etiology of chronic pancreatitis. Since Ca 2+ deregulation can lead to intracellular trypsin activation in experimental acute pancreatitis, we an...
1 CitationsSource
#1Denise Lasher (TUM: Technische Universität München)H-Index: 3
#2András Szabó (BU: Boston University)H-Index: 18
Last. Miklós Sahin-TóthH-Index: 43
view all 29 authors...
OBJECTIVES:Premature activation of the digestive protease trypsin within the pancreatic parenchyma is a critical factor in the pathogenesis of pancreatitis. Alterations in genes that affect intrapancreatic trypsin activity are associated with chronic pancreatitis (CP). Recently, carboxyl ester lipas
17 CitationsSource
#1Roxana Wasnick (University of Giessen)H-Index: 4
#2Martina Korfei (University of Giessen)H-Index: 20
Last. Andreas GuentherH-Index: 32
view all 22 authors...
Alveolar epithelial cell type II (AEC2) injury underlies idiopathic pulmonary fibrosis (IPF). Here we show increased Notch1 signaling in AEC2s in human IPF and IPF models, causing enhanced proliferation and de-differentiation of AEC2s. As a result, we observed defective surfactant protein (SP)-B/C processing, elevated alveolar surface tension, repetitive alveolar collapse and development of lung fibrosis. Similar changes were encountered upon pharmacological inhibition of SP-B/C processing in vi...
5 CitationsSource
#1Matija Hedl (Yale University)H-Index: 17
#2Jie Yan (Yale University)H-Index: 6
Last. Clara Abraham (Yale University)H-Index: 39
view all 4 authors...
Common IFN regulatory factor 5 ( IRF5 ) variants associated with multiple immune-mediated diseases are a major determinant of interindividual variability in pattern recognition receptor (PRR)–induced cytokines in macrophages. PRR-initiated pathways also contribute to bacterial clearance, and dysregulation of bacterial clearance can contribute to immune-mediated diseases. However, the role of IRF5 in macrophage-mediated bacterial clearance is not well defined. Furthermore, it is unclear if macrop...
10 CitationsSource