Javier González-Sabín
University of Oviedo
Amine gas treatingEnantioselective synthesisCatalysisOrganic chemistryEnzymeEutectic systemChemistryBiocatalysisAcylationCombinatorial chemistryKetoneAminolysisCandida antarcticaLipaseDiamineKinetic resolutionEnantiomerBiochemistryEnzyme catalysisStereochemistryEnantiopure drug
74Publications
22H-index
1,071Citations
Publications 69
Newest
Abstract A novel series of enantiopure naphthalimide-cycloalkanediamine conjugates were designed, synthetized and evaluated for in vitro cytotoxicity against human colon adenocarcinoma (LoVo), human lung adenocarcinoma (A549), human cervical carcinoma (Hela) and human promyelocytic leukemia cell lines (HL-60). The cytotoxicity of the compounds was highly dependent on size and relative stereochemistry of the cycloalkyl ring as well as length of the spacer. By contrast, any kind of enantioselectio...
Source
Source
#1Aline Telzerow (Graz University of Technology)H-Index: 3
#2Juraj Paris (Bielefeld University)H-Index: 3
Last. Kerstin Steiner (Graz University of Technology)H-Index: 19
view all 10 authors...
Amine transaminases (ATAs) are used to synthesize enantiomerically pure amines, which are building blocks for pharmaceuticals and agrochemicals. R-selective ATAs belong to the fold type IV PLP-dependent enzymes, and different sequence-, structure- and substrate scope-based features have been identified in the past decade. However, our knowledge is still restricted due to the limited number of characterized (R)-ATAs, with additional bias towards fungal origin. We aimed to expand the toolbox of (R...
Source
#1Luciana Cicco (University of Bari)H-Index: 7
#2José A Hernández-Fernández (University of Oviedo)H-Index: 2
Last. Joaquín García-Álvarez (University of Oviedo)H-Index: 30
view all 10 authors...
An efficient and selective N-functionalization of amides is first reported via a CuI-catalyzed Goldberg-type C-N coupling reaction between aryl iodides and primary/secondary amides run either in Deep Eutectic Solvents (DESs) or water as sustainable reaction media, under mild and bench-type reaction conditions (absence of protecting atmosphere). Higher activities were observed in an aqueous medium, though the employment of DESs expanded and improved the scope of the reaction to include also aliph...
2 CitationsSource
#2Luciana Cicco (University of Bari)H-Index: 7
Last. Javier González-SabínH-Index: 22
view all 8 authors...
The Meyer-Schuster rearrangement of propargylic alcohols into α,β-unsaturated carbonyl compounds has been revisited by setting up an atom-economic process catalyzed by a deep eutectic solvent FeCl3·6H2O/glycerol. Isomerizations take place smoothly, at room temperature, under air and with short reaction times. The unique solubilizing properties of the eutectic mixture enabled the use of a substrate concentration up to 1.0 M with the medium being recycled up to ten runs without any loss of catalyt...
2 CitationsSource
#1David Elorriaga (University of Oviedo)H-Index: 2
#2María J. Rodríguez-Álvarez (University of Oviedo)H-Index: 9
Last. Joaquín García-Álvarez (University of Oviedo)H-Index: 30
view all 8 authors...
A tandem protocol to access tertiary alcohols has been developed which combines the organocatalytic oxidation of secondary alcohols to ketones followed by their chemoselective addition by several RLi reagents. Reactions take place at room temperature, under air and in aqueous solutions, a trio of conditions that are typically forbidden in polar organometallic chemistry.
4 CitationsSource
#1Luciana CiccoH-Index: 7
#2Antonio SalomoneH-Index: 21
Last. Vito CapriatiH-Index: 32
view all 8 authors...
: We first report that highly polarized organometallic compounds of s-block elements add smoothly to chiral N - tert -butanesulfinyl imines in the biodegradable D-sorbitol/choline chloride eutectic mixture, thereby granting access to enantioenriched amines after quantitatively deblocking the sulfinyl group. The practicability of the methodology was further highlighted by (a) working at ambient temperature and under air, (b) very short reaction times (2 min), (c) the preparation of diastereomeric...
6 CitationsSource
#1Luciana Cicco (University of Bari)H-Index: 7
#2Antonio SalomoneH-Index: 21
Last. Vito Capriati (University of Bari)H-Index: 32
view all 8 authors...
Source
#1Robert Kourist (Graz University of Technology)H-Index: 23
Last. Javier González-SabínH-Index: 22
view all 2 authors...
9 CitationsSource
#2María J. Rodríguez-Álvarez (University of Oviedo)H-Index: 9
Last. Joaquín García-Álvarez (University of Oviedo)H-Index: 10
view all 8 authors...
The self-assembly of styrene-type olefins into the corresponding stilbenes was conveniently performed in the Deep Eutectic Solvent (DES) mixture 1ChCl/2Gly under air and in the absence of hazardous organic co-solvents using a one-pot chemo-biocatalytic route. Here, an enzymatic decarboxylation of p-hydroxycinnamic acids sequentially followed by a ruthenium-catalyzed metathesis of olefins has been investigated in DES solvent. Moreover, and to extend the design of chemoenzymatic processes in DESs,...
8 CitationsSource