Fredrik Ghosh
Lund University
AnatomyOphthalmologyH&E stainPathologyChemistryPars planaRetinaGliosisRetinal pigment epitheliumElectroretinographyRetinal detachmentGlial fibrillary acidic proteinRetinalRetinal degenerationVitrectomyGanglionTransplantationMedicineBiologyCell biology
105Publications
19H-index
1,031Citations
Publications 104
Newest
#1Frida Svare (Lund University)
#2Bo Åkerström (Lund University)H-Index: 56
Last. Fredrik Ghosh (Lund University)H-Index: 19
view all 3 authors...
The ex vivo large animal retina is extensively used in research ranging from discovery of disease mechanisms to future treatment paradigms. Due to limited standardization when harvesting the tissue, the time after enucleation is often extended for several hours, a factor that so far has not yet been fully characterized. The purpose of this study was to investigate the relationship between time after enucleation and retinal tissue damage. Adult, porcine retinal explants were dissected and fixed 9...
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#1Henrik Barth (Lund University)H-Index: 3
#2Sven Crafoord (Örebro University)H-Index: 17
Last. Fredrik Ghosh (Lund University)H-Index: 19
view all 3 authors...
To develop a treatment model of rhegmatogenous retinal detachment (RRD) in which the effects of various vitreous tamponades can be explored. In a primary session, detachment was produced in the rig...
2 CitationsSource
#1Linnéa Taylor (Lund University)H-Index: 9
#2Karin Arnér (Lund University)H-Index: 17
Last. Fredrik Ghosh (Lund University)H-Index: 19
view all 4 authors...
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#1Henrik Barth (Lund University)H-Index: 3
#2Sven Crafoord (Örebro University)H-Index: 17
Last. Fredrik Ghosh (Lund University)H-Index: 19
view all 4 authors...
Purpose To investigate the inflammatory response of current and future potential vitreous substitutes in an experimental in vivo vitrectomy model.
6 CitationsSource
#1Henrik Barth (Lund University)H-Index: 3
#2Sven Crafoord (Örebro University)H-Index: 17
Last. Fredrik Ghosh (Lund University)H-Index: 19
view all 3 authors...
Developing a retinal detachment model for in vivo testing of vitreous substitutes with repeated pars plana vitrectomy
#1Linnéa Taylor (Lund University)H-Index: 9
#2Hodan Abdshill (Lund University)H-Index: 3
Last. Fredrik Ghosh (Lund University)H-Index: 19
view all 5 authors...
#1Fredrik Ghosh (Lund University)H-Index: 19
#2Bo Åkerström (Lund University)H-Index: 56
Last. Linnéa TaylorH-Index: 9
view all 6 authors...
The purpose of this study was to explore acute tissue reactions, ultrastructural photoreceptor morphology with emphasis on inner segments, and the effect of antioxidant treatment in an in vitro model of rhegmatogenous retinal detachment (RRD). A previously described method of RRD simulation was used with adult retinal porcine explants kept free-floating in culture medium with or without treatment with the radical scavenger α1-microglobulin (A1M). Explants were examined at 5 time points from 1 to...
2 CitationsSource
#1Fredrik Ghosh (Lund University)H-Index: 19
#2Hodan Abdshill (Lund University)H-Index: 3
Last. Linnéa Taylor (Lund University)H-Index: 9
view all 5 authors...
Abstract The purpose of this study was to explore retina-intrinsic neuroinflammatory reactions, effects on neuronal survival, relationship with classic gliosis, and possible role of the toll-like receptor 4 (TLR4). To isolate the adult retina from the systemic immune system, a previously described large animal explant culture model was used in which full-thickness porcine retinal sheets can be kept in vitro for extended time periods. Explants were kept for 5 days in vitro (DIV) and were treated ...
6 CitationsSource
#1Linnéa Taylor (Lund University)H-Index: 9
#2Karin Arnér (Lund University)H-Index: 17
Last. Fredrik Ghosh (Lund University)H-Index: 19
view all 7 authors...
The purpose of this study was to investigate the adhesion properties and tissue reactions in an in vitro model of nanofabricated membranes emulating the vitreous cortex. Electrospinning was performed for either 5, 10 or 15 min to create various thicknesses of poly(e-caprolactone) (PCL) fibre mats on a poly(glycerol-co-sebacic acid) (PGS) surface. These were fused with adult porcine retinal explants, with the fibre side facing the inner retina, and cultured for 5 days. Adherence was assessed by m...
5 CitationsSource