Gianluigi Zaza
University of Verona
Internal medicinePeripheral blood mononuclear cellPathologyIntensive care medicineImmunologyHeparanaseKidney diseaseEverolimusKidneyKidney transplantationFibrosisTransplantationCancer researchNephrologyBioinformaticsMedicineEpithelial–mesenchymal transitionBiologyGastroenterologyPharmacology
Publications 179
#1Simona GranataH-Index: 17
#2Pierluigi CarratùH-Index: 21
Last. Gianluigi ZazaH-Index: 30
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Kidney transplant recipients are at high risk of developing severe COVID-19 due to the coexistence of several transplant-related comorbidities (e.g., cardiovascular disease, diabetes) and chronic immunosuppression. As a consequence, a large part of SARS-CoV-2 infected patients have been managed with a reduction of immunosuppression. The mTOR-I, together with antimetabolites, have been often discontinued in order to minimize the risk of pulmonary toxicity and to antagonize pharmacological interac...
#1Simona LupinacciH-Index: 7
#2Anna PerriH-Index: 17
Last. Antonella La RussaH-Index: 5
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The mammalian target of rapamycin inhibitor (mTOR-I) Rapamycin, a drug widely used in kidney transplantation, exerts important anti-cancer effects, particularly in Kaposi's Sarcoma (KS), through several biological interactions. In this in vivo and in vitro study, we explored whether the activation of the autophagic pathway through the low-affinity receptor for nerve growth factor, p75NTR , may have a pivotal role in the anti-cancer effect exerted by Rapamycin in S. Our Kimmunohistochemistry resu...
#1Marianna LucafòH-Index: 13
#2Simona GranataH-Index: 17
Last. Gianluigi ZazaH-Index: 30
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To assess whether NLRP3 gene promoter methylation was able to discriminate glucocorticoid-resistant from glucocorticoid-sensitive idiopathic nephrotic syndrome (INS) patients with minimal change disease (MCD) or focal glomerulosclerosis (FSGS), we measured the methylation level of NLRP3 promoter in DNA from peripheral blood cells of 10 adult glucocorticoid-resistant FSGS patients already in hemodialysis and 18 glucocorticoid-sensitive INS patients (13 MCD/5 FSGS) and in 21 INS pediatric patients...
#2Luigina MarsanoH-Index: 8
Last. Ernesto PaolettiH-Index: 24
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There is no specific therapy for polyoma BK virus nephropathy (BKVN) in kidney transplant recipients, a condition associated with poor outcomes. Everolimus showed promising antiviral effects, but data from prospective studies are limited. Therefore, we converted ten consecutive kidney transplant recipients with biopsy-proven BKVN from standard exposure Calcineurin inhibitors and Mycophenolate to Everolimus and reduced exposure Calcineurin inhibitors. Ten patients not administered Everolimus, on ...
3 CitationsSource
The endothelial glycocalyx, the gel layer covering the endothelium, is composed of glycosaminoglycans, proteoglycans, and adsorbed plasma proteins. This structure modulates vessels’ mechanotransduction, vascular permeability, and leukocyte adhesion. Thus, it regulates several physiological and pathological events. In the present review, we described the mechanisms that disturb glycocalyx stability such as reactive oxygen species, matrix metalloproteinases, and heparanase. We then focused our att...
#1Valentina IaconoH-Index: 2
#2Gianmarco LombardiH-Index: 4
Last. Gianluigi ZazaH-Index: 30
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INTRODUCTION Several studies have suggested that chronic kidney disease (CKD) may be associated with olfactory impairment. However, to date, the impact of renal replacement therapies has only been partly defined. METHODS We tested the olfactory function of 235 participants [50 kidney transplant recipients (KT), 49 hemodialyzed patients (HD), 30 peritoneal dialysis patients (PD), 51 patients with CKD not on dialysis (ND-CKD) and 55 healthy subjects (HS)] by the Sniffin' Sticks test (Burghardt®, W...
#1Ilaria GirolamiH-Index: 8
#2Desley Neil (University Hospitals Birmingham NHS Foundation Trust)H-Index: 28
Last. Albino EccherH-Index: 17
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Abstract Background clinical and imaging investigations allow a detailed assessment of an organ donor, but a quota of cancer still elude detection. Complete autopsy of donors is even less frequently performed, due to economic issues and increasing availability of high-quality imaging. The aim of this study is to gather evidence from the literature on donor malignancy discovered at autopsy following organ donation and to discuss the utility and limitations of autopsy practice in the field of tran...
#1Miguel Verbitsky (Columbia University)H-Index: 23
#2Priya Krithivasan (Columbia University)H-Index: 6
Last. Ali G. Gharavi (Columbia University)H-Index: 52
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BACKGROUND Vesicoureteral reflux (VUR) is a common, familial genitourinary disorder, and a major cause of pediatric urinary tract infection (UTI) and kidney failure. The genetic basis of VUR is not well understood. METHODS A diagnostic analysis sought rare, pathogenic copy number variant (CNV) disorders among 1737 patients with VUR. A GWAS was performed in 1395 patients and 5366 controls, of European ancestry. RESULTS Altogether, 3% of VUR patients harbored an undiagnosed rare CNV disorder, such...
Genome-wide association studies have identified numerous genetic variants for type 2 diabetes (T2D). Most genetic loci discovered to date were studied in Caucasians or Asian ancestry, however, there are no data regarding a quite large Italian sample. Therefore, we investigated T2D genetic susceptibility of 143 single nucleotide polymorphisms (SNPs) within 30 genes involved in glucose metabolism in a large Italian case-control study. For the study, 1875 Caucasian patients were selected from three...