Mark Kilbane
University College Dublin
Vitamin D and neurologyInternal medicineObstetricsEndocrinologyBone remodelingFetusChemistryPediatricsProspective cohort studyBone mineralVitaminPregnancyvitamin D deficiencyContext (language use)Parathyroid hormoneBone growthPhysiologyGestationCalciumBone resorptionMedicineCohortGastroenterology
68Publications
13H-index
605Citations
Publications 66
Newest
#1Stephen A. Wise (NIST: National Institute of Standards and Technology)H-Index: 5
#2Johanna E. Camara (NIST: National Institute of Standards and Technology)H-Index: 13
Last. Christian PoppH-Index: 1
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An interlaboratory comparison study was conducted by the Vitamin D Standardization Program (VDSP) to assess the performance of ligand binding assays (Part 2) for the determination of serum total 25-hydroxyvitamin D [25(OH)D]. Fifty single-donor samples were assigned target values for concentrations of 25-hydroxyvitamin D2 [25(OH)D2], 25-hydroxyvitamin D3 [25(OH)D3], 3-epi-25-hydroxyvitamin D3 [3-epi-25(OH)D3], and 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] using isotope dilution liquid chromatog...
2 CitationsSource
#2Rachel K Crowley (UCD: University College Dublin)H-Index: 17
Last. Fionnuala M. McAuliffe (UCD: University College Dublin)H-Index: 57
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Abstract null null Objectives null Clinical studies have reported an inverse relationship between calcium and vitamin D intake and hypertensive disorders of pregnancy (HDP). The aim of this study was to investigate if there was an association between calcium/vitamin D intake, and vitamin D (25OHD) status, and maternal blood pressure (BP), during pregnancy and at 5-year follow-up. null null null Study Design null This was an observational study of 415 women who participated in the ROLO (Randomise...
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#1Johanna E. Camara (NIST: National Institute of Standards and Technology)H-Index: 13
#2Stephen A. Wise (NIH: National Institutes of Health)H-Index: 5
Last. Adam Kuszak (NIH: National Institutes of Health)H-Index: 10
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An interlaboratory study was conducted through the Vitamin D Standardization Program (VDSP) to assess commutability of Standard Reference Materials® (SRMs) and proficiency testing/external quality assessment (PT/EQA) samples for determination of serum total 25-hydroxyvitamin D [25(OH)D] using ligand binding assays and liquid chromatography-tandem mass spectrometry (LC-MS/MS). A set of 50 single-donor serum samples were assigned target values for 25-hydroxyvitamin D2 [25(OH)D2] and 25-hydroxyvita...
2 CitationsSource
#1Mark Kilbane (UCD: University College Dublin)H-Index: 13
#2Rachel K CrowleyH-Index: 17
Last. Patrick J TwomeyH-Index: 22
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Parathyroid hormone-related protein (PTHrP) can simulate most of the actions of parathyroid hormone (PTH) including increases in bone resorption and distal tubular calcium reabsorption and inhibition of proximal tubular phosphate transport.1 The low serum phosphate in parallel with low circulating PTH is consistent with PTHrP involvement in this case. Whether it can be causative for a serum calcium of 6.24 mmol/L however is a moot point. While the mechanism underlying the patient’s severe hyperc...
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#1Aoife Garrahy (UCD: University College Dublin)H-Index: 7
#2Iona Galloway (UCD: University College Dublin)H-Index: 1
Last. Christopher J. Thompson (Beaumont Hospital)H-Index: 30
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CONTEXT Animal data and cross-sectional human studies have established that chronic hyponatraemia predisposes to osteoporosis; the effects of acute hyponatraemia on bone turnover have not been determined. Our objective was to test the hypothesis that acute hyponatraemia leads to dynamic effects on bone turnover. DESIGN A prospective observational pilot study. METHODS Bone turnover markers [C-terminal crosslinking telopeptide of type 1 collagen (CTX-1), N-propeptide of type 1 collagen (P1NP) and ...
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#1E. C. O’Brien (UCD: University College Dublin)H-Index: 2
#2Aisling A. Geraghty (UCD: University College Dublin)H-Index: 9
Last. Fionnuala M. McAuliffe (UCD: University College Dublin)H-Index: 57
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BACKGROUND Pregnancy is characterized by increased bone turnover and reversible loss of bone mineral density (BMD) to meet fetal calcium demands. The long-term effect of bone turnover and maternal diet in pregnancy on maternal bone is not well established. OBJECTIVE We aimed to determine if an association exists between [1] bone resorption, [2] dietary calcium, and [3] serum 25-hydroxyvitamin D in pregnancy with maternal BMD 5-year postpartum. DESIGN This is a prospective, longitudinal study of ...
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#1Malachi J. McKenna (UCD: University College Dublin)H-Index: 29
#2Rachel K Crowley (UCD: University College Dublin)H-Index: 17
Last. Mark Kilbane (UCD: University College Dublin)H-Index: 13
view all 4 authors...
Excess fibroblast growth factor 23 (FGF23), excess PTH, and an increase in extracellular calcium cause hypophosphatemia by lowering the maximum renal phosphate reabsorption threshold (TmP/GFR). We recently reported two cases of X-linked hypophosphatemia (XLH) with severe tertiary hyperparathyroidism who had normalization of TmP/GFR upon being rendered hypoparathyroid following total parathyroidectomy, despite marked excess in both C-terminal FGF23 (cFGF23) and intact FGF23 (iFGF23). We explored ...
1 CitationsSource
#1Aoife Garrahy (Beaumont Hospital)H-Index: 7
#2Iona Galloway (Beaumont Hospital)H-Index: 1
Last. Christopher J. Thompson (Beaumont Hospital)H-Index: 30
view all 13 authors...
Source
#1Maeve Smith (UCD: University College Dublin)H-Index: 1
#2Eileen C O'Brien (UCD: University College Dublin)H-Index: 9
Last. Fionnuala M. McAuliffe (UCD: University College Dublin)H-Index: 57
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Background Vitamin D status may play a role in the development of atopic diseases due to its action on lung development and immune system development and function.
4 CitationsSource
#1A. U. Courtney (UCD: University College Dublin)H-Index: 1
#2E. C. O’Brien (UCD: University College Dublin)H-Index: 2
Last. Fionnuala M. McAuliffe (UCD: University College Dublin)H-Index: 57
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BACKGROUND: High blood pressure (BP) in pregnancy is associated with significant adverse outcomes. In nonpregnant populations, the DASH (Dietary Approaches to Stop Hypertension) diet is associated with reductions in blood pressure. The present study investigated the relationship between the DASH dietary pattern and maternal BP in pregnancy. METHODS: This is an observational study of 511 women who participated in the ROLO study (Randomized cOntrol trial of LOw glycaemic index diet for the prevent...
8 CitationsSource