Shigetoshi Kadota
University of Toyama
CytotoxicityBiological activityInternal medicineEndocrinologyPharmacognosyInhibitory postsynaptic potentialChemistryGlycosideIn vitroTerpenoidDiterpenePropolisTriterpeneTerpeneBiochemistryTraditional medicineBotanyStereochemistryMedicineBiologyPharmacology
329Publications
76H-index
11.3kCitations
Publications 317
Newest
#1Lidyawati Auw (University of Toyama)H-Index: 1
#2Subehan (Hasanuddin University)H-Index: 1
Last. Yasuhiro Tezuka (Hokuriku University)H-Index: 71
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Abstract As constituents of Averrhoa bilimbi leaves we identified three new compounds (1-3) together with 12 known ones (4-15); their inhibitory activities on cytochrome P450 3A4 (CYP3A4) and 2D6 (CYP2D6) were examined. Among the isolated compounds, the mixture of 1 and 2, and compounds 4 and 9 showed strong inhibition on CYP3A4, but mild or no inhibition on CYP2D6. These compounds revealed the characteristics of 1) time- and concentration-dependent inhibition, 2) requirement of NADPH for the in...
1 CitationsSource
#1Dya Fita DibweH-Index: 12
#2Suresh AwaleH-Index: 38
Last. Yasuhiro TezukaH-Index: 71
view all 5 authors...
Source
#1Dya Fita DibweH-Index: 12
#2Suresh AwaleH-Index: 38
Last. Yasuhiro TezukaH-Index: 71
view all 5 authors...
Supporting InformationABSTRACT: Four highly oxygenated xanthones, muchimangins G−J(1−4), have been isolated from the roots of Securidaca longepeduncu-lata collected in Democratic Republic of Congo. Their structures wereelucidated by analyses of spectroscopic data to be fully substitutedxanthones with a diphenylmethyl substituent at C-2.Securidaca longepedunculata Fresen. (Polygalaceae) is animportant traditional folk medicine extensively used in Africa.The roots are used for several diseases suc...
10 CitationsSource
#1Dya Fita Dibwe (University of Toyama)H-Index: 12
#2Suresh Awale (University of Toyama)H-Index: 38
Last. Yasuhiro Tezuka (University of Toyama)H-Index: 71
view all 5 authors...
: Two new diphenylmethyl-substituted xanthones, named muchimangins K (1) and L (2), have been isolated from the roots of Securidaca longepedunculata (Polygalaceae) collected in the Democratic Republic of Congo. Their structures were established by analyses of the spectral data, including 2D NMR spectra, to be 1 ,3,6,8-tetrahydroxy-2.5-dimethoxy-4-[ -(2,4,5-trimethoxyphenyl)-1-phenylmethyl]xanthone (1) and 1,3,6-trihydroxy-4,7-dimethoxy-2-[1-(2,4,5-trimethoxyphenyl)- 1-phenylmethyl]xanthone (2).
2 CitationsSource
#1Teruhito Yamashita (Matsumoto Dental University)H-Index: 14
#2Shunsuke Uehara (Matsumoto Dental University)H-Index: 20
Last. Naoyuki Takahashi (Matsumoto Dental University)H-Index: 90
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Arctigenin, a lignan-derived compound, is a constituent of the seeds of Arctium lappa. Arctigenin was previously shown to inhibit osteoclastogenesis; however, this inhibitory mechanism has yet to be elucidated. Here, we showed that arctigenin inhibited the action of nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), a key transcription factor for osteoclastogenesis. NFATc1 in osteoclast precursors was activated through two distinct pathways: the calcineurin-dependent and osteoblastic c...
7 CitationsSource
#1Hong-Yan Zhang (University of Toyama)H-Index: 2
#2Yu-ichiro Yamakawa (University of Toyama)H-Index: 1
Last. Yasuhiro Tezuka (University of Toyama)H-Index: 71
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Abstract In order to develop new drugs for Alzheimer’s disease, we prepared 17 fatty acid derivatives with different chain lengths and different numbers and positions of double bonds by using Wittig reaction and stereospecific hydrogenation of triple bonds as key reactions. Among them, (4 Z ,15 Z )-octadecadienoic acid ( 10 ) and (23 Z ,34 Z )-heptatriacontadienoic acid ( 16 ) showed the most potent neurite outgrowth activities on Aβ(25–35)-treated rat cortical neurons, which activities were com...
7 CitationsSource
#1Suresh Awale (University of Toyama)H-Index: 38
#2Mamoru Kato (University of Toyama)H-Index: 2
Last. Yasuhiro Tezuka (University of Toyama)H-Index: 71
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Abstract From a MeOH extract of powdered roots of Wikstroemia indica, six dibenzyl-gamma-butyrolactone-type lignans with (2S,3S)-absolute configuration [(+)-arctigenin (1), (+)-matairesinol (2), (+)-trachelogenin (3), (+)-nortrachelogenin (4), (+)-hinokinin (5), and (+)-kusunokinin (6)] were isolated, whereas three dibenzyl-gamma-butyrolactone-type lignans with (2R,3R)-absolute configuration [(-)-arctigenin (1*), (-)-matairesinol (2*), (-)-trachelogenin (3*)] were isolated from Trachelospermum a...
7 CitationsSource
#1Mamoru Kato (University of Toyama)H-Index: 2
#2Yu-Min He (University of Toyama)H-Index: 2
Last. Yasuhiro Tezuka (University of Toyama)H-Index: 71
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: From a MeOH extract of powdered roots of Wikstroemia indica, we isolated a new guaian-type sesquiterpene (1) and two known guaian-type sesquiterpenes [oleodaphnal (2), 1alpha,7alpha,10alphaH-guaia-4,11-dien-3-one (3)], together with twelve known compounds: (+)-arctigenin, (+)-matairesinol, (+)-trachelogenin, (+)-nortrachelogenin, (+)-hinokinin, (+)-kusunokinin, 7-methoxycoumarin, 7-hydroxycoumarin (umbelliferone), daphnogitin, daphnoretin, salicifoliol, and (-)-pinoresinol. The structure of co...
16 CitationsSource
#1Dya Fita Dibwe (University of Toyama)H-Index: 12
#2Suresh Awale (University of Toyama)H-Index: 38
Last. Yasuhiro Tezuka (University of Toyama)H-Index: 71
view all 5 authors...
Abstract In a course of our search for anticancer agent based on a novel anti-austerity strategy, we found that the CHCl 3 extract of the roots of Securidaca longepedunculata (Polygalaceae), collected at Democratic Republic of Congo, killed PANC-1 human pancreatic cancer cells preferentially in nutrient-deprived medium (NDM). Phytochemical investigation on the CHCl 3 extract led to the isolation of 28 compounds including five new polymethoxylated xanthones [1,6,8-trihydroxy-2,3,4,5-tetramethoxyx...
20 CitationsSource
#1Sirivan Athikomkulchai (SWU: Srinakharinwirot University)H-Index: 10
#2Suresh Awale (University of Toyama)H-Index: 38
Last. Shigetoshi Kadota (University of Toyama)H-Index: 76
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Abstract Phytochemical investigation on the constituents of Thai propolis led the isolation of a new phenylallylflavanone, (7″S)-8-[1-(4′-hydroxy-3′-methoxyphenyl)prop-2-en-1-yl]-(2S)-pinocembrin (1) and (E)-cinnamyl-(E)-cinnamylidenate (2) from methanolic extract of Thai propolis. Their structures were determined on the basis of extensive NMR spectroscopic analysis. In addition to this, 19 compounds (3–21) belonging to flavonoids and phenolic esters were isolated and identified.
28 CitationsSource