Niek E. van der Aa
Utrecht University
Internal medicineSurgeryMagnetic resonance imagingDiffusion MRIPsychologyCardiologyPediatricsMiddle cerebral arteryInternal capsuleGestational ageEncephalopathyCerebral palsyOptic radiationWhite matterPerinatal arterial ischemic strokeAnesthesiaStrokeMedicineTractographyFractional anisotropy
34Publications
12H-index
452Citations
Publications 36
Newest
#1Lisa M. Hortensius (UU: Utrecht University)H-Index: 3
#2Els Janson (UU: Utrecht University)
Last. Ruurd M. van Elburg (UU: Utrecht University)
view all 13 authors...
Background: Determining optimal nutritional regimens in extremely preterm infants remains challenging. This study aimed to evaluate the effect of a new nutritional regimen and individual macronutrient intake on white matter integrity and neurodevelopmental outcome. Methods: Two retrospective cohorts of extremely preterm infants (gestational age < 28 weeks) were included. Cohort B (n = 79) received a new nutritional regimen, with more rapidly increased, higher protein intake compared to cohort A ...
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#1Astrid Nieuwets (UU: Utrecht University)H-Index: 2
#2Mehmet N. Cizmeci (UU: Utrecht University)
Last. Niek E. van der Aa (UU: Utrecht University)H-Index: 12
view all 9 authors...
Data on microstructural white matter integrity in preterm infants with post-hemorrhagic ventricular dilatation (PHVD) using diffusion tensor imaging (DTI) are limited. Also, to date, no study has focused on the DTI changes in extremely preterm (EP) infants with PHVD. A case–control study of EP infants <28 weeks’ gestation with PHVD was conducted. Diffusivity and fractional anisotropy (FA) values of corticospinal tracts (CST) and corpus callosum (CC) were measured using DTI at term-equivalent age...
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#1Burcu Cebeci (UU: Utrecht University)
#2Thomas Alderliesten (UU: Utrecht University)H-Index: 18
Last. Floris Groenendaal (UU: Utrecht University)H-Index: 74
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BACKGROUND Preterm infants are at risk of neurodevelopmental impairments. At present, proton magnetic resonance spectroscopy (1H-MRS) is used to evaluate brain metabolites in asphyxiated term infants. The aim of this review is to assess associations between cerebral 1H-MRS and neurodevelopment after preterm birth. METHODS PubMed and Embase were searched to identify studies using 1H-MRS and preterm birth. Eligible studies for this review included 1H-MRS of the brain, gestational age ≤32 weeks, an...
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#1Kim V. Annink (UU: Utrecht University)H-Index: 6
#2Lilly Meerts (UU: Utrecht University)H-Index: 1
Last. Jeroen Dudink (UU: Utrecht University)H-Index: 25
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BACKGROUND Postmortem examinations frequently show cerebellar injury in infants with severe hypoxic-ischemic encephalopathy (HIE), while it is less well visible on MRI. The primary aim was to investigate the correlation between cerebellar apparent diffusion coefficient (ADC) values and histopathology in infants with HIE. The secondary aim was to compare ADC values in the cerebellum of infants with HIE and infants without brain injury. METHODS ADC values in the cerebellar vermis, hemispheres and ...
2 CitationsSource
#1Kim V. Annink (Boston Children's Hospital)H-Index: 6
#2Linda S. de Vries (Boston Children's Hospital)H-Index: 39
Last. Niek E. van der Aa (Boston Children's Hospital)H-Index: 12
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The mammillary bodies (MB) and hippocampi are important for memory function and are often affected following neonatal hypoxic ischemic encephalopathy (HIE). The aim of this study was to assess neurodevelopmental outcome in 10-year-old children with HIE with and without therapeutic hypothermia. Additional aims were to assess the associations between MB atrophy, brain volumes (including the hippocampi), white matter microstructure and neurodevelopmental outcome at school-age. Ten-year-old children...
2 CitationsSource
#1Nienke Wagenaar (UU: Utrecht University)H-Index: 7
#2Cornelia H. Verhage (UU: Utrecht University)H-Index: 4
Last. Niek E. van der Aa (UU: Utrecht University)H-Index: 12
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Neonates with unilateral perinatal brain injury (UPBI) are at risk for developing unilateral spastic cerebral palsy (USCP). This study compares several predictors for USCP later in life. Twenty-one preterm and 24 term born infants with UPBI were included, with an MRI scan including diffusion tensor imaging (DTI) performed at term equivalent age or around 3 months after birth, respectively. T2-weighted images and DTI-based tractography were used to measure the surface area, diameter, and fraction...
4 CitationsSource
#1Sabine Ouwehand (UU: Utrecht University)H-Index: 2
#2Lisanne C. A. Smidt (UU: Utrecht University)H-Index: 2
Last. Niek E. van der Aa (UU: Utrecht University)H-Index: 12
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INTRODUCTION: Prediction of neurodevelopmental outcome in infants with hypoxic-ischemic encephalopathy remains an important challenge. Various studies have shown that the predictive ability of different modalities changed after the introduction of therapeutic hypothermia. This paper reviews the diagnostic test accuracy of the different modalities that are being used to predict neurodevelopmental outcomes following therapeutic hypothermia. METHODS: A systematic literature search was performed usi...
11 CitationsSource
#1Aicha B.C. Dijkshoorn (UU: Utrecht University)H-Index: 2
#2Elise Turk (UU: Utrecht University)H-Index: 7
Last. Jeroen Dudink (UU: Utrecht University)H-Index: 25
view all 8 authors...
The cerebellum is connected to numerous regions of the contralateral side of the cerebrum. Motor and cognitive deficits following neonatal cerebellar hemorrhages (CbH) in extremely preterm neonates may be related to remote cortical alterations, following disrupted cerebello-cerebral connectivity as was previously shown within six CbH infants. In this retrospective case series study, we used MRI and advanced surface-based analyses to reconstruct gray matter (GM) changes in cortical thickness and ...
5 CitationsSource
#1Kim V. Annink (UU: Utrecht University)H-Index: 6
#2Floris Groenendaal (UU: Utrecht University)H-Index: 74
Last. Jannie P. Wijnen (UU: Utrecht University)H-Index: 21
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Little is known about brain temperature of neonates during MRI. Brain temperature can be estimated non-invasively with proton Magnetic Resonance Spectroscopy (1H-MRS), but the most accurate 1H-MRS method has not yet been determined. The primary aim was to estimate brain temperature using 1H-MRS in infants with neonatal encephalopathy following perinatal asphyxia (NE). The secondary aim was to compare brain temperature during MRI with rectal temperatures before and after MRI. In this retrospectiv...
2 CitationsSource
#1Nienke Wagenaar (UU: Utrecht University)H-Index: 7
#2Daphne J.M. van den Berk (UU: Utrecht University)H-Index: 1
Last. Thomas Alderliesten (UU: Utrecht University)H-Index: 18
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Background and Purpose— In infants with perinatal arterial ischemic stroke (PAIS), early prognosis of neurodevelopmental outcome is important to adequately inform parents and caretakers. Early cont...
7 CitationsSource