Kendo Kiyosawa
Shinshu University
Internal medicineEndocrinologyPathologyAntigenVirologyAntibodyImmunologyVirusHepatitisHepatitis C virusHepatitis CAutoimmune hepatitisCirrhosisHepatocellular carcinomaHepatitis B virusViral diseaseHepatologyMedicineBiologyGastroenterology
486Publications
86H-index
14.2kCitations
Publications 493
Newest
A 78-year-old woman was admitted for examination and treatment of melena. Although upper and lower gastrointestinal endoscopy and abdominal computed tomography showed no bleeding lesions, oral double-balloon endoscopy revealed a long, slender polyp covered with normal mucosa and accompanied with erosions in the proximal jejunum. Surgical resection was successful. Histopathologically, the polyp was 125 mm in length and composed of edematous mucosa with dilated blood vessels. The growth was diagno...
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#1Ayumi Sugiura (Shinshu University)H-Index: 11
#2Satoru Joshita (Shinshu University)H-Index: 27
Last. Takeji Umemura (Shinshu University)H-Index: 40
view all 32 authors...
Glecaprevir/pibrentasvir (G/P) are direct-acting antivirals (DAAs) that achieve a high sustained virological response (SVR) rate for hepatitis C virus (HCV) infection. We investigated G/P effectiveness for HCV patients based on real-world experience and the clinical features of retreatment cases. HCV patients (n = 182) were compared for clinical features and outcomes between first treatment (n = 159) and retreatment (n = 23) G/P groups. Overall, 77 patients (42.3%) were male, the median age was ...
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Last. Hiroaki Okamoto (Jichi Medical University)H-Index: 113
view all 7 authors...
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#1Shigeyuki Kawa (Matsumoto Dental University)H-Index: 68
#2Kendo KiyosawaH-Index: 86
Last. Hideaki Hamano (Shinshu University)H-Index: 44
view all 3 authors...
Abstract Immunoglobulin G4–related disease (IgG4-RD) is a recently established systemic disease that is characteristically associated with IgG4 and is considered to be caused by autoimmune mechanisms. The clinical features of IgG4-RD can be summarized as (1) systemic distribution; (2) imaging findings of swelling, nodules, and/or wall thickening; (3) high serum IgG4 concentration; (4) abundant lymphoplasmacytic and IgG4-bearing plasma cell infiltration in affected organs; (5) a favorable respons...
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It has been unknown if attenuated insulin sensitivity (Si) in non-alcoholic fatty liver disease (NAFLD) is a cause or a result. We examined the impact of attenuated Si on NAFLD evolution. We observed 4856 NAFLD- and diabetes-free participants for a mean 2.9 years. Si was indexed by single point insulin sensitivity estimator (SPISE = [600 × HDL-c0.185]/[TG0.2 × BMI1.338]), correlating with 1/HOMA-IR in an independent cohort (n = 1537, Spearman rho = 0.519, P 10.06) as the reference, tertile 1 (<8...
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#1Ayumi Sugiura (Shinshu University)H-Index: 11
#2Satoru Joshita (Shinshu University)H-Index: 27
Last. Eiji Tanaka (Shinshu University)H-Index: 94
view all 31 authors...
: Direct-acting antiviral (DAA) treatment can achieve a high sustained virological response (SVR) rate in patients with hepatitis C virus (HCV) infection regardless of a history of hepatocellular carcinoma (HCC [+]). We examined 838 patients (370 men, median age: 69 years) who were treated with DAAs for comparisons of clinical findings between 79 HCC (+) (9.4%) and 759 HCC (-) (90.6%) patients and associations with treatment outcome. Male frequency was significantly higher in the HCC (+) group (...
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#8Yoshio Sumida (NARA: National Archives and Records Administration)H-Index: 42
The genetic factors affecting the natural history of nonalcoholic fatty liver disease (NAFLD), including the development of nonalcoholic steatohepatitis (NASH) and NASH-derived hepatocellular carcinoma (NASH-HCC), are still unknown. In the current study, we sought to identify genetic factors related to the development of NAFLD, NASH, and NASH-HCC, and to establish risk-estimation models for them. For these purposes, 936 histologically proven NAFLD patients were recruited, and genome-wide associa...
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#1Ayumi SugiuraH-Index: 11
#2Shuichi WadaH-Index: 7
Last. Kendo KiyosawaH-Index: 86
view all 8 authors...
Persistent hepatitis C virus (HCV) infection may induce autoimmune diseases and chronic hepatitis C is sometimes accompanied by autoimmune hepatitis (AIH). However, we are worried about the treatment for chronic hepatitis C-AIH overlap syndrome because interferon-based antiviral therapies may enhance autoimmunity and immunosuppressive corticosteroid administration may promote viral replication. Here, we report a patient having chronic hepatitis C-AIH overlap syndrome treated with the direct-acti...
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#1Takefumi Kimura (Shinshu University)H-Index: 18
#2Akira Kobayashi (Shinshu University)H-Index: 23
Last. Eiji Tanaka (Shinshu University)H-Index: 94
view all 18 authors...
Aim Past hepatitis B virus (HBV) infection is considered a risk factor for hepatocarcinogenesis, but the clinicopathological characteristics of non-B non-C hepatocellular carcinoma (NBNC-HCC) excluding past HBV infection have not been investigated. This study aimed to clarify the clinicopathological features of strictly defined NBNC-HCC. Methods Among HCC patients who underwent surgical resection at our affiliated hospitals in Nagano prefecture, Japan, between 1996 and 2012, 77 were negative for...
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#1Masafumi MaruyamaH-Index: 2
#2Naoki Tanaka (Shinshu University)H-Index: 47
Last. Kendo KiyosawaH-Index: 86
view all 13 authors...
Background. A new agent, potassium-competitive acid blocker vonoprazan (VPZ) has potent acid-inhibitory effects and may offer advantages over conventional H. pylori eradication therapies. We aimed to compare the eradication rate between VPZ-based treatment and PPI-based one. Methods. This randomized controlled trial was designed to assign 141 patients with H. pylori-positive gastritis to VPZ group (VPZ 20 mg, amoxicillin 750 mg, and clarithromycin 200 or 400 mg twice daily for 7 days) or PPI gro...
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